DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam6a

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_777479.2	Gene:	Adam6a / 238406	MGIID:	2676316	Length:	754	Species:	Mus musculus

Alignment Length:	747	Identity:	175/747 - (23%)
Similarity:	292/747 - (39%)	Gaps:	133/747 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LNSQLLSPNIQQKHYHVGGYLVD----------GNRHDIE------------------------- 161
            ::|:::.|  :::.||..|....          |.||.|.
Mouse    46 ISSEVVIP--RKEIYHTKGLQAQRLLSYSLRFRGQRHIIHLRRKTLIWPRHLLLTTQDDQGALQM 108

  Fly   162 -------HCYYHGTVKDYPGASAAFHTC-NGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEART 218
                   .|||.|.::....:.....|| .|:||||.:.|.|:.|.|.  .|.....|::.:..:
Mouse   109 EYPFFPVDCYYIGYLEGILQSMVTVDTCYGGLSGVIKLDNLTYEIKPL--NDSQSFEHLVSQIVS 171

  Fly   219 KANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQA-GVGR-NKRDVREATKYIETAIIVDKA 281
            :::    ::|.:::|      ||.|.........:..| |..| :.::.......|:.......:
Mouse   172 ESD----DTGPMNAW------KHWSHNTGSPSSRLEYADGAPRLSSKNYATHPAAIKGHFQATHS 226

  Fly   282 MFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFND 346
            ::....|...:..:....:|.::.|.|...|:.|..|..:..:.:....   |:|........:.
Mouse   227 VYSASGGDKLSSTVEYLFKVISLMDTYLTNLHMRYYVFLMTVYTEADPF---SQDFRVPGGQAHT 288

  Fly   347 YTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGH 411
            :..|..:...|.....:..:...|.:|......::|:|.|: |.:..:...|..|:..:.:.:|.
Mouse   289 FYERVFYAHFRPDAGAIINKNSPGDDAVNPAERSICSPSAL-ICLGQHGRNPLFLSIIITNRVGR 352

  Fly   412 NIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQ-PYKFSECSKKDYIDALRTGHGL-CLLNKP- 473
            ::|:.||:|  .|.|:..:.|||.      :|.| ...||.||..:..:.|.|...: ||....
Mouse   353 SLGLKHDEG--YCICQRRNTCIMF------KNPQLTDAFSNCSLAEISNILNTPDLMPCLFYDRH 409

  Fly   474 ---NEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKD 535
               |.....:.|||..|:.:|:||||:.:.|..|.|| |..|:|...:.|....||..|...|..
Mouse   410 VYYNTSLTYKFCGNFKVDNNEQCDCGSQKACYSDPCC-GNDCRLTPGSICDKELCCANCTYSPSG 473

  Fly   536 YICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYG 600
            .:||...|.|||||||.|....||.|.:.::|:||     ...|||::|.|...::||..|:|..
Mouse   474 TLCRPIQNICDLPEYCSGSKFICPDDTYLQDGTPC-----SEEGYCYKGNCTDRNIQCMEIFGVS 533

  Fly   601 GSAADRQCYEQFNSKGSINGHCGRDANEH--YIKCEPENVQCGTLQCKDGERQP-VNDGIDQLYS 662
            ...|:.:||: .|.:....|||.| |.|.  :..|..::..||.|||.:....| :.:.:.  :.
Mouse   534 AKNANIKCYD-INKQRFRFGHCTR-AEESLTFNACADQDKLCGRLQCTNVTNLPFLQEHVS--FH 594

  Fly   663 RTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQ 727
            :::||    ...|.......|:.: .:.|||:.||||.....|....|......:.....|.
Mouse   595 QSVIS----GVTCFGLDEHRGTET-ADAGLVRHGTPCSRGKFCDRGACNGSLSRLGYDCTPE--- 651

  Fly   728 GLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSD--- 789
              :|:..|||.|...|.|..||....|                         |:|...|:.|
Mouse   652 --KCNFRGVCNNRRNCHCHFGWSPPKC-------------------------KEEGHSGSIDSGS 689

  Fly   790 ---QNRI--STLTMVIILTVIVKCVFISFATL 816
               |.||  ..|..|:.|.::...::..|..|
Mouse   690 PPVQRRIIKQNLEPVVYLRILFGRIYFLFVAL 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	26/123 (21%)
		Reprolysin	270..473	CDD:279729	40/204 (20%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	40/202 (20%)
		Disintegrin	488..562	CDD:278623	30/73 (41%)
		ACR	566..713	CDD:214743	42/149 (28%)
Adam6a	NP_777479.2	Pep_M12B_propep	69..166	CDD:279848	21/98 (21%)
		ZnMc_adamalysin_II_like	217..406	CDD:239797	40/200 (20%)
		Disintegrin	427..500	CDD:278623	30/73 (41%)
		ACR	503..638	CDD:214743	41/148 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850