DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam6b

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001009545.1	Gene:	Adam6b / 238405	MGIID:	2444636	Length:	756	Species:	Mus musculus

Alignment Length:	757	Identity:	188/757 - (24%)
Similarity:	306/757 - (40%)	Gaps:	153/757 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LNSQLLSPNIQQKHYHVGGYLVD----------GNRHDIE------------------------- 161
            ::|:::.|  :::.||..|....          |.||.|.
Mouse    46 ISSEVVIP--RKEIYHTKGLQAQRLLSYSLHFRGQRHIIHLRRKTLIWPRHLLLTTQDDQGALQM 108

  Fly   162 -------HCYYHGTVKDYPGASAAFHTC-NGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEART 218
                   .|||.|.::..|.:.....|| .|:|||:.:.:.|:.|.|.  .|.....|::.:..:
Mouse   109 DYPFFPVDCYYIGYLEGIPQSMVTVDTCYGGLSGVMKLDDLTYEIKPL--NDSQSFEHLVSQIVS 171

  Fly   219 KANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMF 283
            :::    ::|.:::|      ||.|.. .|.....|:...|.    .|.::|...|.....|..|
Mouse   172 ESD----DTGPMNAW------KHWSHN-TGSPSSRLEYADGA----PRISSKNYATHPAAIKGHF 221

  Fly   284 DKRN-------GSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQ------AVIDGSK 335
            ...|       |...:..:....||.::.|.|...|:.|..|..:..:..:.      ||..||.
Mouse   222 QATNSVYNSAAGDKLSSTVGYLFQVISLMDTYLTNLHMRYYVFLMTVYTNSDPFRLEFAVPGGSA 286

  Fly   336 DISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVP--ETVCTPRAVGISVDVNVYE- 397
                    :|.|.|....:.:.|...||..   .|.:.....|  .::|:..|:   :.:..|:
Mouse   287 --------YNYYVSVFYNKFKPDAGVLLNK---YGPQDNQVNPAERSICSSLAL---ICIGKYDR 337

  Fly   398 -PHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPY---KFSECSKKDYI 458
             |..|:..:.:.:|.::|:.:|:|  .|.|:..:.|||.:        .|.   .||.||..:..
Mouse   338 NPLFLSPIITNRVGRSLGLKYDEG--YCVCQRRNTCIMFR--------HPQLTDAFSNCSLAEIS 392

  Fly   459 DALRTGHGL--CLLNKP----NEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSE 517
            :.|.| .||  ||....    |.....:.|||..|:.||:||||:.:.|..|.|| |..|:|...
Mouse   393 NILNT-PGLMPCLFYDRHVYYNTSLTYKFCGNFKVDNDEQCDCGSQKACYSDPCC-GNDCRLTPG 455

  Fly   518 AQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCF 582
            :.|....||..|...|...:||...|.|||||||:|....||.|.:.::|:||     ...|||:
Mouse   456 SICDKELCCANCTYSPSGTLCRPIQNICDLPEYCNGTKYICPDDTYLQDGTPC-----SEDGYCY 515

  Fly   583 QGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEH--YIKCEPENVQCGTLQC 645
            :|.|...::||..|:|.....|:.:||: .|.:....|||.| |.|.  :..|..::..||.|||
Mouse   516 KGNCTDRNIQCMEIFGVSAKNANIKCYD-INKQRFRFGHCTR-AEESLTFNACADQDKLCGRLQC 578

  Fly   646 KDGERQP-VNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQT 709
            .:....| :.:.:.  :.::|||    .|.|.......|:.: .:.|:|:.||||..:..|....
Mouse   579 TNVTNLPYLQEHVS--FHQSIIS----GFTCFGLDEHRGTET-TDAGMVRHGTPCSKSKFCDQGA 636

  Fly   710 CVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPEN 774
            |.....|:.....|.     :||..|||.|...|.|..||...:|.... |:.::.:.:.|...:
Mouse   637 CSGSLSHLGYDCTPE-----KCSFRGVCNNHRNCHCHFGWKPPECKEEG-LSGSIDSGSPPVQRH 695

  Fly   775 TIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATL 816
            |||  :|:.|              |:.|.::...::..|..|
Mouse   696 TIK--QKQEP--------------VVYLRILFGRIYFLFVAL 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	25/123 (20%)
		Reprolysin	270..473	CDD:279729	50/224 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	50/222 (23%)
		Disintegrin	488..562	CDD:278623	31/73 (42%)
		ACR	566..713	CDD:214743	43/149 (29%)
Adam6b	NP_001009545.1	Pep_M12B_propep	69..166	CDD:279848	20/98 (20%)
		ZnMc_adamalysin_II_like	217..406	CDD:239797	48/213 (23%)
		Disintegrin	427..500	CDD:278623	31/73 (42%)
		ACR	503..637	CDD:214743	42/147 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850