DRSC/TRiP Functional Genomics Resources

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Protein Alignment mmd and Adam25

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_035911.2 Gene:Adam25 / 23793 MGIID:1345157 Length:760 Species:Mus musculus


Alignment Length:898 Identity:239/898 - (26%)
Similarity:369/898 - (41%) Gaps:217/898 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWINIANLILIIAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYY 65
            :|:.|.|::                      |.|.           |..|.|:..|.        
Mouse    33 VWLEILNIL----------------------SSWP-----------LTGYAQHTSLP-------- 56

  Fly    66 QIIYPVQLRHHEKM-GISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLD 129
            :::.|:::..:..| .:.....||...||                |||    :.|||  .||   
Mouse    57 EVVIPLRVTGNRPMWAMGWLTYSLHFGGQ----------------KHF----IHIKA--KKF--- 96

  Fly   130 LELNSQLLSPNIQQKHYHVGGYLVDGNRHDIE-----HCYYHGTVKDYPGASAAFHTC-NGVSGV 188
              |.|:|.|         |..|...|..|..:     .|||||.:...|.:..|..|| .|..|:
Mouse    97 --LVSRLFS---------VFTYTKQGALHKDQPYVQNDCYYHGHMDGDPESMVAITTCYGGFQGI 150

  Fly   189 IHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEI 253
            :.|....:.|.|       |:....||...:         .:|    |..|:.|....| :.|||
Mouse   151 LQINGTVYEIKP-------KNLSSTFEHLVQ---------KMD----SEETELLPMRCA-LTEEI 194

  Fly   254 L-QAGVGRNKRDVREATKY---------IETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLY 308
            . |..:.:|:......:.|         ::.|::|::......|.:| :.|:.:...:.||.:..
Mouse   195 ARQMKLQQNENPTLMQSHYEGWWTHKSFLDLALVVERERIRYHNNNT-SRVLVEVFTIINIINNI 258

  Fly   309 FRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAGGE 372
            :.||:..:.::.:|.|.:...|  ..:.|.:.:..|..:.:|:| |:|..|...:.....| |..
Mouse   259 YETLDVELVLLGVEMWNERNHV--QVRSIEELLDEFCMWKARSLNFRIPNDIAHIFVNHEF-GIY 320

  Fly   373 AGMAVPETVCTPRAVGISVDVNVYEPHLLAGTM-------AHMIGHNIGMGHDDGREECFCRDWH 430
            .|:|...:||.| :....||      .||.|.:       ||.:|||:||.||.  ..|.|    
Mouse   321 LGLAYIGSVCVP-SHNCGVD------RLLGGNLFYFGRIIAHEMGHNLGMEHDS--SSCTC---- 372

  Fly   431 G---CIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEE 492
            |   |:||.:    :|..| |||.||...|.....|...:....|...|...:.||:.||::.|:
Mouse   373 GRKICLMAPA----DNGIP-KFSNCSYSYYWATYATAKCMRKEKKSKGILRGKLCGDGVVDDGEQ 432

  Fly   493 CDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQ 557
            ||||:.:.||.|.||.. :|.||..|.||.|.||..|::.|...:||...|||||||:|:|...:
Mouse   433 CDCGSAKSCADDPCCKP-SCTLKDGAACAFGLCCLYCQIMPAGTVCRQEVNECDLPEWCNGHSHK 496

  Fly   558 CPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHC 622
            ||:||:..:||||   :.|  |||::..|.....||:.|:|....:||..||.:.|::|...|:|
Mouse   497 CPNDVYLLDGSPC---RDG--GYCYEKRCNNRDEQCKQIFGKEARSADHSCYRELNTQGDRFGNC 556

  Fly   623 G--RDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFE---CKATSGQV 682
            |  |||   |::|...::.||.:||::....|        :.|...::......   |..|....
Mouse   557 GVIRDA---YLRCHDPDILCGRVQCENVAHIP--------FLRDHSTVHWTHLNGVTCWGTDYHF 610

  Fly   683 GSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDM 747
            |. :.|:.|:|||||.||...:|:|:.|||  ..:.:::|...:    |:..|||.|.:.|.|::
Mouse   611 GM-TIPDIGIVKDGTDCGPEHVCINKKCVS--KSIWRSQCSPKT----CNMKGVCNNLHHCHCNL 668

  Fly   748 GWGGNDCSSVVLLTTALPTEALPTPEN-----TIKMEKKETPYGTSDQNRISTLTMVIILTVIVK 807
            ||....|     |.:.|.......|.|     |.|..||             ::.:||:..::..
Mouse   669 GWDPPHC-----LKSGLGGSIDSGPPNYTENYTEKKHKK-------------SIGLVILFWILFA 715

  Fly   808 C---VFISFATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHHSVEEV 857
            |   :||.|......|        .:.|.|::|      ...|..|.....||
Mouse   716 CFSVLFIVFLFFLRSY--------VELPMSEEP------KVPTPENKEDTNEV 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 31/112 (28%)
Reprolysin 270..473 CDD:279729 56/222 (25%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 56/220 (25%)
Disintegrin 488..562 CDD:278623 34/73 (47%)
ACR 566..713 CDD:214743 49/151 (32%)
Adam25NP_035911.2 Pep_M12B_propep 69..173 CDD:279848 38/146 (26%)
Cysteine switch. /evidence=ECO:0000250 186..193 1/7 (14%)
ZnMc_adamalysin_II_like 222..399 CDD:239797 54/198 (27%)
Reprolysin 222..397 CDD:279729 53/196 (27%)
Disintegrin 428..501 CDD:278623 34/73 (47%)
ACR 504..640 CDD:214743 50/154 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 738..760 5/23 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836154
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3607
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 1 1.000 - - X50
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.880

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