Protein Alignment mmd and Adam25

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_035911.2
• Gene: Adam25 / 23793
• MGIID: 1345157
• Length: 760
• Species: Mus musculus
• Alignment Length: 898
• Identity: 239/898 - (26%)
• Similarity: 369/898 - (41%)
• Gaps: 217/898 - (24%)

  Fly     1 MWINIANLILIIAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYY 65
            :|:.|.|::                      |.|.           |..|.|:..|.
Mouse    33 VWLEILNIL----------------------SSWP-----------LTGYAQHTSLP-------- 56

  Fly    66 QIIYPVQLRHHEKM-GISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLD 129
            :::.|:::..:..| .:.....||...||                |||    :.|||  .||
Mouse    57 EVVIPLRVTGNRPMWAMGWLTYSLHFGGQ----------------KHF----IHIKA--KKF--- 96

  Fly   130 LELNSQLLSPNIQQKHYHVGGYLVDGNRHDIE-----HCYYHGTVKDYPGASAAFHTC-NGVSGV 188
              |.|:|.|         |..|...|..|..:     .|||||.:...|.:..|..|| .|..|:
Mouse    97 --LVSRLFS---------VFTYTKQGALHKDQPYVQNDCYYHGHMDGDPESMVAITTCYGGFQGI 150

  Fly   189 IHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEI 253
            :.|....:.|.|       |:....||...:         .:|    |..|:.|....| :.|||
Mouse   151 LQINGTVYEIKP-------KNLSSTFEHLVQ---------KMD----SEETELLPMRCA-LTEEI 194

  Fly   254 L-QAGVGRNKRDVREATKY---------IETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLY 308
            . |..:.:|:......:.|         ::.|::|::......|.:| :.|:.:...:.||.:..
Mouse   195 ARQMKLQQNENPTLMQSHYEGWWTHKSFLDLALVVERERIRYHNNNT-SRVLVEVFTIINIINNI 258

  Fly   309 FRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAGGE 372
            :.||:..:.::.:|.|.:...|  ..:.|.:.:..|..:.:|:| |:|..|...:.....| |..
Mouse   259 YETLDVELVLLGVEMWNERNHV--QVRSIEELLDEFCMWKARSLNFRIPNDIAHIFVNHEF-GIY 320

  Fly   373 AGMAVPETVCTPRAVGISVDVNVYEPHLLAGTM-------AHMIGHNIGMGHDDGREECFCRDWH 430
            .|:|...:||.| :....||      .||.|.:       ||.:|||:||.||.  ..|.|
Mouse   321 LGLAYIGSVCVP-SHNCGVD------RLLGGNLFYFGRIIAHEMGHNLGMEHDS--SSCTC---- 372

  Fly   431 G---CIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEE 492
            |   |:||.:    :|..| |||.||...|.....|...:....|...|...:.||:.||::.|:
Mouse   373 GRKICLMAPA----DNGIP-KFSNCSYSYYWATYATAKCMRKEKKSKGILRGKLCGDGVVDDGEQ 432

  Fly   493 CDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQ 557
            ||||:.:.||.|.||.. :|.||..|.||.|.||..|::.|...:||...|||||||:|:|...:
Mouse   433 CDCGSAKSCADDPCCKP-SCTLKDGAACAFGLCCLYCQIMPAGTVCRQEVNECDLPEWCNGHSHK 496

  Fly   558 CPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHC 622
            ||:||:..:||||   :.|  |||::..|.....||:.|:|....:||..||.:.|::|...|:|
Mouse   497 CPNDVYLLDGSPC---RDG--GYCYEKRCNNRDEQCKQIFGKEARSADHSCYRELNTQGDRFGNC 556

  Fly   623 G--RDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFE---CKATSGQV 682
            |  |||   |::|...::.||.:||::....|        :.|...::......   |..|....
Mouse   557 GVIRDA---YLRCHDPDILCGRVQCENVAHIP--------FLRDHSTVHWTHLNGVTCWGTDYHF 610

  Fly   683 GSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDM 747
            |. :.|:.|:|||||.||...:|:|:.|||  ..:.:::|...:    |:..|||.|.:.|.|::
Mouse   611 GM-TIPDIGIVKDGTDCGPEHVCINKKCVS--KSIWRSQCSPKT----CNMKGVCNNLHHCHCNL 668

  Fly   748 GWGGNDCSSVVLLTTALPTEALPTPEN-----TIKMEKKETPYGTSDQNRISTLTMVIILTVIVK 807
            ||....|     |.:.|.......|.|     |.|..||             ::.:||:..::..
Mouse   669 GWDPPHC-----LKSGLGGSIDSGPPNYTENYTEKKHKK-------------SIGLVILFWILFA 715

  Fly   808 C---VFISFATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHHSVEEV 857
            |   :||.|......|        .:.|.|::|      ...|..|.....||
Mouse   716 CFSVLFIVFLFFLRSY--------VELPMSEEP------KVPTPENKEDTNEV 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	31/115 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	56/220 (25%)
		Disintegrin	488..561	CDD:459709	34/72 (47%)
		ACR	566..713	CDD:214743	49/151 (32%)
Adam25	NP_035911.2	Pep_M12B_propep	57..173	CDD:460254	39/158 (25%)
		Cysteine switch. /evidence=ECO:0000250	186..193		1/7 (14%)
		ZnMc_adamalysin_II_like	222..399	CDD:239797	54/198 (27%)
		Disintegrin	428..500	CDD:459709	34/72 (47%)
		ACR	504..640	CDD:214743	50/154 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..760		5/23 (22%)