Protein Alignment mmd and Adam23

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_035910.1
• Gene: Adam23 / 23792
• MGIID: 1345162
• Length: 829
• Species: Mus musculus
• Alignment Length: 727
• Identity: 236/727 - (32%)
• Similarity: 352/727 - (48%)
• Gaps: 96/727 - (13%)

  Fly   111 HFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGG--YLVDGNRHDIEHCYYHGTVKDYP 173
            |..:.|..|:||..||.|||.||:.|||.:..:.||..|.  |...|     |||||||:::...
Mouse   144 HLAQASFQIEAFGSKFILDLTLNNGLLSSDYVEIHYEDGKQMYSKGG-----EHCYYHGSIRGVK 203

  Fly   174 GASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSK---HPHVIFEA----RTKANKGCANSGNLD 231
            .:..|..||||:.|:.......::|.|....|..|   .||:|.:.    .:|..|..:..|: |
Mouse   204 DSRVALSTCNGLHGMFEDDTFVYMIEPLELTDDEKSTGRPHIIQKTLAGQYSKQMKNLSTDGS-D 267

  Fly   232 SWRL------SRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGST 290
            .|.|      .||.|.......||.||:                ||:|..|:.|...: |::.|:
Mouse   268 QWPLLPELQWLRRRKRAVNPSRGVFEEM----------------KYLELMIVNDHKTY-KKHRSS 315

  Fly   291 RAEVIHDAIQVANIAD-LYFRTLNTRVSVVYIETWGKNQAVIDGSKDIS----KAISNFNDYTSR 350
            .|...:.|..|.|:.| :|...|||||.:|.:|||.:...:     ||:    :.:.:|:.|..|
Mouse   316 HAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDHI-----DITINPVQMLHDFSKYRQR 375

  Fly   351 NLFQIERDTTQLLTGETFAGGEAGMAVPETVCTP-RAVGISVDVNVYE-PHLLAGTMAHMIGHNI 413
              .:...|...|::..||....:.::....||:. |.||    ||.|. |..:|..::..:..|:
Mouse   376 --IKQHADAVHLISRVTFHYKRSSLSYFGGVCSRIRGVG----VNEYGLPMAVAQVLSQSLAQNL 434

  Fly   414 GMGHDDG--REECFC-RDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNE 475
            |:..:..  :.:|.| ..|.||||.::.|....    |||:||..:|.|.|:.|.|.||.|:|.:
Mouse   435 GIQWEPSSRKPKCECIESWGGCIMEETGVSHSR----KFSKCSILEYRDFLQRGGGACLFNRPTK 495

  Fly   476 IELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCD--QCRLRPKDYIC 538
            :.....|||..||..||||||...|| ...||.  .|.|.:.|.|:.|.||:  .|..:.:.|.|
Mouse   496 LFEPTECGNGYVEAGEECDCGFHVEC-YGVCCK--KCSLSNGAHCSDGPCCNNTSCLFQSRGYEC 557

  Fly   539 RDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSA 603
            ||:.|.||:.|||.|:.||||.::.|::|..|..::    |.|:.|.|.|...||:.|||...:.
Mouse   558 RDAVNSCDITEYCTGDSGQCPPNLHKQDGYSCNQNQ----GRCYNGECKTRDNQCQYIWGTKAAG 618

  Fly   604 ADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISI 668
            :|:.|||:.|::|:..|:||:| .:.:|.|...:|.||.|.|.:..|.|   .|.||....|.:.
Mouse   619 SDKFCYEKLNTEGTEKGNCGKD-GDRWIPCSKHDVFCGFLLCTNLTRAP---RIGQLQGEIIPTS 679

  Fly   669 ---KGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLE 730
               :|:..:|  :...|..:...:.|.|:||||||.:::||::.|:.: ..::.:.||.:|:|..
Mouse   680 FYHQGRVIDC--SGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQI-QALNMSSCPLDSRGKV 741

  Fly   731 CSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNR-IS 794
            ||.||||:|...|.||..|.|.|||             :..|.......|.|.|.|.|..|. |.
Mouse   742 CSGHGVCSNEATCICDFTWAGTDCS-------------IRDPVRNPNPPKDEGPKGPSATNLIIG 793

  Fly   795 TLTMVIILTVIV 806
            ::...|::..||
Mouse   794 SIAGAILVAAIV 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	39/107 (36%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	63/210 (30%)
		Disintegrin	488..561	CDD:459709	34/74 (46%)
		ACR	566..713	CDD:214743	49/149 (33%)
Adam23	NP_035910.1	Pep_M12B_propep	144..246	CDD:460254	39/106 (37%)
		Reprolysin	296..493	CDD:426256	64/212 (30%)
		Disintegrin	508..580	CDD:459709	34/74 (46%)
		ACR	584..723	CDD:214743	48/148 (32%)