DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Gm4787

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001034084.2	Gene:	Gm4787 / 214321	MGIID:	3646380	Length:	748	Species:	Mus musculus

Alignment Length:	836	Identity:	221/836 - (26%)
Similarity:	326/836 - (38%)	Gaps:	190/836 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RHHEKMGISTREVSLP-KPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFR-----LDLEL 132
            |...|...||.|:.:| |..||....|.||          |.|      ::.:||     :.::|
Mouse    35 RSPPKWRFSTSEIVIPRKVPQRMGKSDMSG----------HIT------YSMRFRGQRHVVHMKL 83

  Fly   133 NSQLLSPNI----------QQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC-NGVS 186
            ...::..|.          |||.|....          ..||::..::..||:.|...|| .|:.
Mouse    84 KKNMIPQNFPVYTSNDQGAQQKDYPFVP----------RDCYFYSYLEGVPGSQATLDTCTGGLK 138

  Fly   187 GVIHIGNETFVIHPFYGGDLSKHPHVI----FEARTKANKGCANS------GNLDS--------- 232
            |:|.:.:.|:.|.|.  ...||..|||    .:.|::.:|.|.|.      |||..
Mouse   139 GMIQVDDFTYEIKPL--ASSSKFEHVISLLVVDERSRESKKCRNDEIMAKVGNLPEETKLAGSPR 201

  Fly   233 ------WRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFD--KRNGS 289
                  ||...:    :.|:...|...|...:|.|      :|..||..:|:......  |.:|.
Mouse   202 AAPVYLWRYHSK----NVGIQYTVTHELYTQIGSN------STASIELILIMTSISHSIYKTSGM 256

  Fly   290 TRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQ 354
            .   |...|..:.|..|.|      .:|..|...|              :.:..|..:.:...:.
Mouse   257 F---VFARAACIWNDKDHY------SISSFYNNVW--------------RLMELFGYWKAGYFWH 298

  Fly   355 IERDTTQLLTGE-----TFAGGEAGMAVPETVCTPR--AVGISVDVNVYEPHLLAGT-MAHMIGH 411
            :|..||.||.|.     .:||.:.|      :|.|.  .:...|..|.:   .|||: :||.:||
Mouse   299 MEHATTALLLGRKLGNTDYAGFQDG------ICNPNWGVLYTYVGTNHF---FLAGSFLAHAVGH 354

  Fly   412 NIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCL--LNKPN 474
            .:.:.||.....||.|.  .|:|.:....|:.:     |.|| .|.:.....|...|:  :.:.:
Mouse   355 LLNVRHDTPGCVCFRRS--SCLMDEFPTLQDMI-----SNCS-HDVLHMRIHGWDPCMSEVRRTH 411

  Fly   475 EIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICR 539
            .|:....||||:||..|.||||:.::|..|:||: :.|:....:.|..|.||..|:..|...|||
Mouse   412 NIQNVPRCGNKIVEGSESCDCGSVKDCTTDKCCE-VDCEFTQGSSCNKGGCCLSCKFAPTGTICR 475

  Fly   540 DSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAA 604
            |.|..|||||||.|....||.:.:..:|:||  |...:   |..|.|....|||:|::||....:
Mouse   476 DKNGICDLPEYCSGASEHCPGNFYIMDGTPC--SPLAV---CIAGNCTDRHLQCQALFGYQVKDS 535

  Fly   605 DRQCYEQFNSKGSINGHCG---RDANEHYIKCEPENVQCGTLQCKDGERQPVNDG-IDQLYSRTI 665
            ...||.:.|.||...|:||   :......:.|:.|:|.||.|.| ||.::.|..| ....|...:
Mouse   536 SPACYHELNVKGDRFGNCGVRIKRGGSQTVPCQKEDVFCGMLHC-DGVKRIVGGGEHTTFYHLKV 599

  Fly   666 ISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLE 730
            ..:|  |.:|.......|.: .||.|||.||..||....|.||.||  |....:..|..:|
Mouse   600 QDVK--EVQCFGYDIHHGLD-LPEIGLVMDGATCGPGKYCKNQRCV--FHQTLKFNCNISS---- 655

  Fly   731 CSEHGVCTNTNRCFCDMGW----------GGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPY 785
            |:..|||.|...|.|..||          ||:..|..:              .|.:|.      |
Mouse   656 CNFRGVCNNQGNCHCVQGWQPPKCLQRGKGGSVNSGPI--------------TNPLKR------Y 700

  Fly   786 GTSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKYDPPYSKKPIAKS 841
            .......|:.|.:::...:.:....|.|..||....|        |...::|.|.|
Mouse   701 RAKIHVSINKLLIILGARIFLIVALIIFGALAKAVLR--------PEVPQRPPANS 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	26/122 (21%)
		Reprolysin	270..473	CDD:279729	48/214 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	48/212 (23%)
		Disintegrin	488..562	CDD:278623	32/73 (44%)
		ACR	566..713	CDD:214743	51/150 (34%)
Gm4787	NP_001034084.2	Pep_M12B_propep	60..163	CDD:279848	29/130 (22%)
		ZnMc_adamalysin_II_like	213..405	CDD:239797	54/241 (22%)
		Disintegrin	425..498	CDD:278623	32/73 (44%)
		ACR	501..642	CDD:214743	49/149 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850