DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mmd and ADAM32

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_659441.4 Gene:ADAM32 / 203102 HGNCID:15479 Length:787 Species:Homo sapiens


Alignment Length:780 Identity:196/780 - (25%)
Similarity:337/780 - (43%) Gaps:122/780 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 LELNSQLLSPNIQQKHYHVGGYLV----DGNRH----DIE-HCYYHGTVKDYPGASAAFHTCNGV 185
            :.::.:|.:.:::|:::....:::    .|:.:    ||: .|||.|.::.||.:.....||:|:
Human    53 IPIDEKLYTVHLKQRYFLADNFMIYLYNQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGL 117

  Fly   186 SGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVV 250
            .|::...|.::.|.|....  .:..||:::.:.:.|                       .:|..:
Human   118 RGILQFENVSYGIEPLESA--VEFQHVLYKLKNEDN-----------------------DIAIFI 157

  Fly   251 EEILQAGVGRNKRDVREATK---------YIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIAD 306
            :..|:.....:...:.|.::         |:|..|:|||.::|.. ||....|.:..|::..:|:
Human   158 DRSLKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLYDYW-GSDSMIVTNKVIEIVGLAN 221

  Fly   307 LYFRTLNTRVSVVYIETWG-KNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAG 370
            ..|......:.:..:|.|. :|:....|..|  :.:..|.::....|.....|...||....:. 
Human   222 SMFTQFKVTIVLSSLELWSDENKISTVGEAD--ELLQKFLEWKQSYLNLRPHDIAYLLIYMDYP- 283

  Fly   371 GEAGMAVPETVCTPRAVGISVDVNVYEPHL----LAGTMAHMIGHNIGMGHDDGREECFCRDWHG 431
            ...|...|.|:|..|   .|..|.:|...:    .|..:..|:..::|:.:||.: :|.|.: ..
Human   284 RYLGAVFPGTMCITR---YSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPK-KCQCSE-ST 343

  Fly   432 CIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN-----CGNKVVEEDE 491
            |||...:|....|:  .||.||.:.:.:.:......||.|||   ::::.     |||..:|.:|
Human   344 CIMNPEVVQSNGVK--TFSSCSLRSFQNFISNVGVKCLQNKP---QMQKKSPKPVCGNGRLEGNE 403

  Fly   492 ECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICR-DSNNECDLPEYCDGEI 555
            .|||||..:|....|||..||.||..|:|..|.||..|::......|| .::.|||:.|.|:|..
Human   404 ICDCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTS 468

  Fly   556 GQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSING 620
            .:|..|:...||..|..:|.    .|:.|.|..|..:||:::|.|...|...|||:..|:....|
Human   469 PECGPDITLINGLSCKNNKF----ICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFG 529

  Fly   621 HCGRDANEHYIKCEPENVQCGTLQCKDGERQPVN-DGIDQLYSRTIISIKGQEFECKATSGQVGS 684
            :||||.|..|:.|...|:.||.|.|....|:|.: :..|.:|:....|:      |.....:: .
Human   530 NCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSV------CITVDYKL-P 587

  Fly   685 NSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGW 749
            .:.|:...||:|:.|....:|:|:.||.  ..:.:......||  :||.||||.:.|:|.|..|:
Human   588 RTVPDPLAVKNGSQCDIGRVCVNRECVE--SRIIKASAHVCSQ--QCSGHGVCDSRNKCHCSPGY 648

  Fly   750 GGNDCSSVVLLTTALPTE--------ALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIV 806
            ...:|.......:..|.|        |....|||..:            ..:..|.::|:.|.||
Human   649 KPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLL------------GFLIALPILIVTTAIV 701

  Fly   807 KCVFISFATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHHSVEEVSLDGSSKLVYANQT 871
                     ||....:|....:.:.|.|:   :||.|...|..:..|.|     ||:: .||:||
Human   702 ---------LARKQLKKWFAKEEEFPSSE---SKSEGSTQTYASQSSSE-----GSTQ-TYASQT 748

  Fly   872  871
            Human   749  748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 19/91 (21%)
Reprolysin 270..473 CDD:279729 50/216 (23%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 49/214 (23%)
Disintegrin 488..562 CDD:278623 30/74 (41%)
ACR 566..713 CDD:214743 45/147 (31%)
ADAM32NP_659441.4 Pep_M12B_propep 27..144 CDD:307618 20/92 (22%)
Reprolysin 187..383 CDD:307535 50/206 (24%)
Disintegrin 400..474 CDD:306668 30/73 (41%)
ADAM_CR 479..593 CDD:312126 37/124 (30%)
SEEEED <714..>786 CDD:317234 14/44 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..787 14/43 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146059
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3607
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

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