DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam6

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_620261.1	Gene:	Adam6 / 192271	RGDID:	621472	Length:	751	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	166/678 - (24%)
Similarity:	268/678 - (39%)	Gaps:	144/678 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 CYYHGTVKDYPGASAAFHTC-NGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCAN 226
            |||.|.::..|.:....:|| .|:.|::.:.:..:.|.|.  .|.....|::.:..::.:.
  Rat   117 CYYFGYLEGIPQSMVTVNTCYGGLEGIMMLDDLAYEIKPL--NDSQGFEHIVSQIVSEPDV---- 175

  Fly   227 SGNLDSWR---------LSRR-----TKHLS----AGVAGVVEEILQA--GVGRNKRDVREATKY 271
            :|..::|:         |||.     |..:|    |.....::...||  .:.:...::..|.:|
  Rat   176 TGPTNTWKRLNLNTGPPLSRTEYANGTPRMSSKNYASHPAAIKGQFQATNSIYKESNNIDTAARY 240

  Fly   272 IETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKN-----QAVI 331
            :                          .::.:|.|.:..|::.|...:.:..:.::     :..:
  Rat   241 L--------------------------FELLSITDSFLITIHMRYYAILLTVFTESDPFALEYTV 279

  Fly   332 DGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVY 396
            .|.       |.:|.|.|....::..|.:.:|..:..:..:. ..|.:::|||  .|::: |..:
  Rat   280 PGG-------SIYNYYVSNFFNRLRPDASTVLNKDGPSDNDF-HPVEQSLCTP--AGLTI-VGQH 333

  Fly   397 EPHLLAGTMAHMIGHNIGMG---HDDGREECFCRDWHGCIMAQSIVGQENVQPYK-------FSE 451
            ....||  ::.||.:.|.|.   ..|....|.|.....|||            ||       ||.
  Rat   334 RRSFLA--LSVMITNRIAMSLGIKADDETYCICHRRTTCIM------------YKNPEITDAFSN 384

  Fly   452 CSKKDYIDALRT-GHGLCLLNK----PNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGIT 511
            ||.......|.| |...||...    .|..:..|.|||..::..|:||||:.:.|..|.|| |..
  Rat   385 CSLVQINQILNTPGTMSCLFYDHHVYHNITKTYRFCGNFKIDIGEQCDCGSHKACYADPCC-GSN 448

  Fly   512 CKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTG 576
            |||.:.:.|....||..|...|...:||...|.|||||||.|....||:|.:.::|:||     .
  Rat   449 CKLTAGSICDKELCCANCTYSPSGTLCRPIQNICDLPEYCSGNNIFCPADTYLQDGTPC-----S 508

  Fly   577 ISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEH--YIKCEPENVQ 639
            ..|||::|.|...|:||:.|:|.....|:.:||: .|.:....|||.| |.|.  :..|...:..
  Rat   509 EEGYCYKGNCTDRSVQCKEIFGMNAKGANIKCYD-INKQRFRFGHCTR-AQESLMFNACSDHDKL 571

  Fly   640 CGTLQCKDGERQP-VNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNL 703
            ||.|||.:....| :.:.:.  :.:::||    .|.|.......|:.: .:.||||.||||....
  Rat   572 CGRLQCTNVTNLPFLQEHVS--FHQSVIS----GFTCFGLDEHRGTET-TDAGLVKHGTPCSQTN 629

  Fly   704 ICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGW-----------GGNDCSSV 757
            .|....|......:|....|.     :|:..|||.|...|.|.:||           |..|..|.
  Rat   630 FCDRGACNGSLSRLDYDCTPE-----KCNFRGVCNNHRHCHCHLGWKPPLCREEGPSGSTDSGSP 689

  Fly   758 VLLTTALPTEALPTPENTIKMEKKETPY 785
                        |....|||..::...|
  Rat   690 ------------PKERRTIKQSREPLLY 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	13/50 (26%)
		Reprolysin	270..473	CDD:279729	41/222 (18%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	41/216 (19%)
		Disintegrin	488..562	CDD:278623	31/73 (42%)
		ACR	566..713	CDD:214743	45/149 (30%)
Adam6	NP_620261.1	Pep_M12B_propep	64..166	CDD:279848	13/50 (26%)
		ZnMc_adamalysin_II_like	217..405	CDD:239797	44/238 (18%)
		Disintegrin	428..499	CDD:278623	31/71 (44%)
		ACR	502..637	CDD:214743	44/148 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339807
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850