DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and tag-275

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_509031.2	Gene:	tag-275 / 180886	WormBaseID:	WBGene00016423	Length:	472	Species:	Caenorhabditis elegans

Alignment Length:	264	Identity:	64/264 - (24%)
Similarity:	106/264 - (40%)	Gaps:	56/264 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 TKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQV-ANI------ADLYFRTLNTRVSVVYIETWGK 326
            |.:|.:.:.||        ..|.|....|.|:| .||      |:.|...|...:.||.|....:
Worm    50 TVFIRSLVFVD--------NKTTAYYEFDMIRVKLNIMKMVDEANQYLNQLGVGLIVVGILQTNR 106

  Fly   327 NQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISV 391
            .        |:|  :.:|::|.:..|.::.......|....:||   |:|....:|:..:|.:|
Worm   107 G--------DLS--LQSFHEYRNSRLHKLPDHEFATLISYKYAG---GLAYVNGMCSSHSVSLS- 157

  Fly   392 DVNVY--EPHLLAGTMAHMIGHNIGMGHDDGRE-----ECFC--RD---WHGCIMAQSIVGQENV 444
              ..|  ||..:.....|.:.|.:|:.|....|     .|.|  :|   ..||:   .|.|.::
Worm   158 --GFYPNEPRAMGSIFFHEVAHLVGVPHRAVNESIYVPNCLCTPKDSLKEDGCL---KIPGFDH- 216

  Fly   445 QPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDG 509
                  :|:.:.:::.:....  |:|..|...:....|||.|:|..|:||||....|: |..|..
Worm   217 ------DCTVQQFVNTIYKNK--CILKHPIFEQSEPVCGNGVLENGEDCDCGLPGRCS-DLNCQP 272

  Fly   510 ITCK 513
            .||:
Worm   273 HTCR 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848
		Reprolysin	270..473	CDD:279729	47/221 (21%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	46/219 (21%)
		Disintegrin	488..562	CDD:278623	11/26 (42%)
		ACR	566..713	CDD:214743
tag-275	NP_509031.2	ZnMc	57..234	CDD:381785	45/212 (21%)
tag-275	NP_509031.2	Disintegrin	252..>277	CDD:385688	11/26 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5934
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870