DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and sup-17

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_492377.1	Gene:	sup-17 / 172689	WormBaseID:	WBGene00006324	Length:	922	Species:	Caenorhabditis elegans

Alignment Length:	908	Identity:	198/908 - (21%)
Similarity:	295/908 - (32%)	Gaps:	331/908 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 AFNHKFRLDLE-LNSQLLSPNIQQKHYHVGGYLVDGNRHDIE--HCYYHGTVKDYPGASAAFHTC 182
            |:|..|.:.|. ::..|...:      |:..  |||...||:  |..|.|.:||.|.:.......
Worm    72 AYNRTFHVQLHPIDDSLFHED------HMSD--VDGGYADIKPSHFLYEGYLKDDPNSHVHGSVF 128

  Fly   183 NGV-SGVIHIG-NETFVIHP----FYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKH 241
            :|| .|.|..| ...:.|..    |...|.....|.|.....:.|.        ..||:.|..::
Worm   129 DGVFEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINH--------RKWRVKRDAEN 185

  Fly   242 LSAGVAGV---------VEEILQAGV------------GRNKRD-----------VREATKYIET 274
            ||..:.|.         :.::..:|.            ||:||.           ||..:.|::
Worm   186 LSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQ- 249

  Fly   275 AIIVDKAMFD---KRNGS-----TRAEVI---HDAIQVAN----------IADLYFRTLNTRVSV 318
               .|..:::   .:.|:     ||.|::   ::.|:..|          |..|:|  :..|.|:
Worm   250 ---ADHKLYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTNFNGIKGLHF--VIQRTSI 309

  Fly   319 VYIETWGKNQAVIDGSK-------DISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMA 376
            ...::..:.:|..|...       |:|..: |.|...:.:.|.:    ...||...|.||..|:|
Worm   310 YTPDSCDRGRAKTDSDNPFCEENVDVSNFL-NLNSQRNHSAFCL----AYALTFRDFVGGTLGLA 369

  Fly   377 VPETVCTPR--------------------------AVGISVDVNVYEPHLLAG----TMAHMIGH 411
               .|.:|:                          ..||...|| |...:.|.    |:||.|||
Worm   370 ---WVASPQFNTAGGICQVHQRYNEGSRGWVYRSLNTGIVTLVN-YGNRVPARVSQLTLAHEIGH 430

  Fly   412 NIGMGHD----------DGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHG 466
            |.|..||          ||          ..||..|....:.....|||.||.|: |.|:
Worm   431 NFGSPHDFPAECQPGLPDG----------NFIMFASATSGDKPNNGKFSPCSVKN-ISAV----- 479

  Fly   467 LCLLNKPNEIELRRN-------------------CGNKVVEEDEECDCGTFEECALDQ----CC- 507
            |.::.|...::..||                   |||::.|..|||||| |.:...||    ||
Worm   480 LAVVLKSMPVDPTRNASPVGIGKRNCFQERTSAFCGNQIYEPGEECDCG-FSQADCDQMGDKCCV 543

  Fly   508 ---------DGITCKLKSEAQC--ASGACC--DQCRLRPK--DYICRDSNNECDLPEYCDGEIGQ 557
                     .| .||.|..|||  :.|.||  |.|.|..|  :.||| ..:||...:.|||...|
Worm   544 PHEARGNGGPG-PCKRKPGAQCSPSQGYCCNPDTCSLHGKNEEKICR-QESECSNLQTCDGRNAQ 606

  Fly   558 CPSDVFKKNGSPC-GLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGH 621
            ||....|.:|.|| ..:|...||.|....|....|:              .|   |.::|..:..
Worm   607 CPVSPPKHDGIPCQDSTKVCSSGQCNGSVCAMFGLE--------------DC---FLTEGKADEL 654

  Fly   622 CGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNS 686
            |       ::.|           .|||              :...|:...||....|:.......
Worm   655 C-------FLAC-----------IKDG--------------KCTSSVHLPEFSANRTNFLQNMRK 687

  Fly   687 YPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGG 751
            .....::..|:||                                       |..:.:||:   .
Worm   688 DKPGLILHPGSPC---------------------------------------NNYKGYCDI---F 710

  Fly   752 NDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQN----RISTLTMVIILTVIVKCVFIS 812
            ..|.||.........:.|...:.||     ||....:..|    .:..|..::|:.:.|||..:.
Worm   711 RKCRSVDANGPLARLKNLLFNKRTI-----ETLTQWAQDNWWVVGVGGLVFLVIMALFVKCCAVH 770

  Fly   813 --------------FATLAVCYRRKTTTLKYD-----------PPYSKKPIAKSYGGAATAPN 850
                          :.||.    |..|.::..           ||   .|.|:...|||:||:
Worm   771 TPSTNPNKPPALNIYQTLT----RPGTLIRQHRQRHRAAAGSVPP---GPGAQPRSGAASAPS 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	26/100 (26%)
		Reprolysin	270..473	CDD:279729	59/270 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	59/268 (22%)
		Disintegrin	488..562	CDD:278623	37/93 (40%)
		ACR	566..713	CDD:214743	24/147 (16%)
sup-17	NP_492377.1	Pep_M12B_propep	50..142	CDD:307618	22/77 (29%)
		ZnMc_TACE_like	242..513	CDD:239798	63/301 (21%)
		DISIN	520..611	CDD:214490	37/93 (40%)
		Ribosomal_L19e	<805..897	CDD:320841	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920