Protein Alignment mmd and Adam24

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_034216.3
• Gene: Adam24 / 13526
• MGIID: 105984
• Length: 761
• Species: Mus musculus
• Alignment Length: 744
• Identity: 201/744 - (27%)
• Similarity: 337/744 - (45%)
• Gaps: 117/744 - (15%)

  Fly   146 YHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC-NGVSGVIHIGNETFVIHPFYGGDLSKH 209
            |:..|.|.:........|||.|.|.....:.||..|| .|..|::.|.:..:.|.|       |.
Mouse    93 YNDQGVLFEDRPFVQNDCYYLGFVDGDLESMAALTTCFGGFQGILQINDTAYEIKP-------KS 150

  Fly   210 P-----HVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEIL--QAGVGRNKRDVRE 267
            |     |::::              :||.:...|...     .|:.:|.:  |..:..|.:..|.
Mouse   151 PSSTFEHLLYK--------------IDSEKTQLRPMR-----CGLTDEEIAGQVRLQENGKSTRM 196

  Fly   268 AT---------KYIETAIIVD--KAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYI 321
            .:         .||:.|:::|  :.::.|:|.|.   ||.|.:.:....:|:..:::..|.::.:
Mouse   197 QSIYGSWWSHGLYIKLALVIDHEQYLYRKKNTSL---VIRDVLSIMQGINLFLLSVDINVVLLGL 258

  Fly   322 ETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAGGEAGMAVPETVCTPR 385
            ..|.....:  ..:||...:..|..:...|| .||..|...|....||: ...|:|...||| .:
Mouse   259 TIWTNGNPI--PVQDIYALLPAFCTWKGTNLDSQIPYDIAHLFVNYTFS-NYFGIAYVGTVC-DK 319

  Fly   386 AVGISVDVNVYEPHLLAG-TMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKF 449
            ..|..:|....:..|..| .:||.||||:||.||.  ..|.|.: ..|:|:.::...:     |.
Mouse   320 TFGCGIDSIAEDDFLTIGHIVAHEIGHNLGMSHDG--ILCTCGE-ESCLMSATMDSSQ-----KL 376

  Fly   450 SECSKKDYIDALRTGHGLCLLNK--------PNEIELRRNCGNKVVEEDEECDCGTFEECALDQC 506
            |.||.:     :...|   ::||        |::|...:.|||.:|||.|:||||:.|.|..::|
Mouse   377 SNCSYE-----VLWAH---MINKSCIHREPRPSDIFQLKVCGNGIVEEGEQCDCGSSENCRRNRC 433

  Fly   507 CDGITCKLKSEAQCASGACCD-QCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPC 570
            |.. :|.|:|:|:|.:|.||: :|:::|...:||...|||||||:|:|...:||.|:|.::|:.|
Mouse   434 CMP-SCTLRSKAKCDTGLCCNRKCQIQPSGTLCRARENECDLPEWCNGTSHECPEDLFVQDGTSC 497

  Fly   571 GLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEP 635
                .| .|||::..|.:..:.|:.::|.....|...||::.|::|...|:||...|| |::||.
Mouse   498 ----PG-DGYCYEKRCNSHDVHCQRVFGQLAMKASDSCYKELNTRGDRFGNCGFINNE-YVRCEI 556

  Fly   636 ENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCG 700
            .::.||.:||......|:   :...|  ||.........|.:|...:|. ...:.|.:||||.||
Mouse   557 SDILCGRIQCDKVGTLPI---LQNHY--TIHWTHFNSVSCWSTDYHLGM-KIADLGDIKDGTNCG 615

  Fly   701 DNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVL---LTT 762
            ...:|:.:.||:....|:.  |...:    |:..|||.|...|.||:||...:|.....   :.:
Mouse   616 PQHVCIARKCVNKPSWVND--CTPET----CNMKGVCNNKQHCHCDVGWSPPNCQETGTGGSIDS 674

  Fly   763 ALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVF-ISFATLAVCYRRKTTT 826
            ..|...:...|...|.:..|.|      |.|..|..:|.:.|::..:| :|.||      :|:..
Mouse   675 GSPGNEVYEDEVVSKKDAPEKP------NVIIWLLPIICVAVVLSVLFCLSGAT------KKSRE 727

  Fly   827 LKYDPPYSKKPIAKSYGGAATAPNHHSVE 855
            .....| :::.:...|.||  .|::.:|:
Mouse   728 AAASQP-AEERVKPPYEGA--EPSYETVK 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	20/73 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	52/204 (25%)
		Disintegrin	488..561	CDD:459709	34/73 (47%)
		ACR	566..713	CDD:214743	43/146 (29%)
Adam24	NP_034216.3	Pep_M12B_propep	42..160	CDD:460254	20/73 (27%)
		Cysteine switch. /evidence=ECO:0000250	172..179		1/11 (9%)
		ZnMc_adamalysin_II_like	209..395	CDD:239797	54/208 (26%)
		Disintegrin	415..488	CDD:459709	34/73 (47%)
		ACR	492..628	CDD:214743	43/147 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..761		6/32 (19%)