DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam18

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_034214.2	Gene:	Adam18 / 13524	MGIID:	105986	Length:	719	Species:	Mus musculus

Alignment Length:	655	Identity:	183/655 - (27%)
Similarity:	275/655 - (41%)	Gaps:	87/655 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 NHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSG 187
            ||.|          ||.|.....|:..|.|...:.|.:.||:|.|.|.:.|.:......|:|:.|
Mouse    61 NHSF----------LSQNFLVYTYNETGSLYSDSSHFLAHCHYRGYVDEVPNSIVTLSICSGLRG 115

  Fly   188 VIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEE 252
            .:.:.|.::.|.|....  ::..|::::.::.::....|..::  |::.:..|       |...|
Mouse   116 FLQLENVSYGIEPLESS--ARFEHIVYQVKSDSSMLAGNDSHV--WQIDQLDK-------GHFNE 169

  Fly   253 ILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVS 317
                   ::|...:...:.::..|||.|.:||.. ||....:.....|:..:.:.....|...|.
Mouse   170 -------QDKNHSQLLPQSLKLHIIVGKFLFDYM-GSDIMAITQKIFQIIGLVNAMLTQLKLSVV 226

  Fly   318 VVYIETWG-KNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETF-------AGGEAG 374
            :..:|.|. ||....||         |..|...| |...:||...|.:.|..       .....|
Mouse   227 LASLELWSDKNHISTDG---------NATDILQR-LLDWKRDYLTLQSNEITHLLIYRRRPKYIG 281

  Fly   375 MAVPETVCTPRAVGISVDVNVYEPHL-LAG---TMAHMIGHNIGMGHDDGREECFCRDWHGCIMA 435
            .|.|..:|:...|   ..|.:|...: |.|   .:..:||.:||:.:||....|.|.. ..|||.
Mouse   282 AASPGEICSKSYV---AGVGMYPEDIGLEGFSVVITQLIGLHIGLTYDDNIRNCSCPS-APCIMQ 342

  Fly   436 QSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN---CGNKVVEEDEECDCGT 497
            |..:.....:  .||.||..||:..:......||.:..|...|:.|   |||.::|..||||||.
Mouse   343 QGALSSSGKK--TFSNCSLHDYMHYVSNFDTQCLGDLSNVHVLQPNQAVCGNGIMEAGEECDCGN 405

  Fly   498 FEECALDQCCDGITCKLKSEAQCASGACC-DQCRLRPKDYICRDS-NNECDLPEYCDGEIGQCPS 560
            ..||...:|||..||:||..|||.||||| ..|.|......||.: :.|||..|||||....|..
Mouse   406 ETECQFKECCDHETCRLKGSAQCGSGACCMPTCELSASGTPCRKAVDPECDFTEYCDGSSSHCVP 470

  Fly   561 DVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRD 625
            |.|..||..|.|.    |.||:.|.|..|:.||.:::|.|...|...|:|:.||......:|  |
Mouse   471 DTFALNGHLCRLG----SAYCYNGRCQALNDQCVSLFGKGSQGASYACFEKVNSPRENLANC--D 529

  Fly   626 ANEHY-IKCEPENVQCGTLQCKDGERQPVNDGIDQLY---SRTIISIKGQEFEC-KATSGQVGSN 685
            :.:.| :.|..::|.||.|.|   .|.|.|      |   |::::.....:..| ....|....:
Mouse   530 SKDSYSVPCGQQDVLCGKLAC---FRPPKN------YKSPSQSVVYSYVHDSVCLSILPGLSMRS 585

  Fly   686 SYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWG 750
            ...:...|.|||.||..:.|:|.||..:  :.....|.|..   :|..:|:|.|...|.|...:.
Mouse   586 DGRDSAYVADGTVCGPQMYCINGTCKEV--NFTGNDCNATK---KCKGNGICNNFGNCQCFPDYR 645

  Fly   751 GNDCS 755
            ..||:
Mouse   646 PPDCN 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	23/89 (26%)
		Reprolysin	270..473	CDD:279729	54/214 (25%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	54/212 (25%)
		Disintegrin	488..562	CDD:278623	37/75 (49%)
		ACR	566..713	CDD:214743	45/151 (30%)
Adam18	NP_034214.2	Pep_M12B_propep	30..139	CDD:279848	23/89 (26%)
		Reprolysin	182..374	CDD:279729	52/208 (25%)
		ZnMc_adamalysin_II_like	182..374	CDD:239797	52/208 (25%)
		Disintegrin	396..472	CDD:278623	37/75 (49%)
		ACR	475..613	CDD:214743	45/152 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920