DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam28

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_034212.1	Gene:	Adam28 / 13522	MGIID:	105988	Length:	793	Species:	Mus musculus

Alignment Length:	738	Identity:	234/738 - (31%)
Similarity:	363/738 - (49%)	Gaps:	99/738 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPR 96
            ||.....||..::.|.|..:             |:::||::|....|     ||...|:|
Mouse    10 SFLLSPVPVSAIKELPKAKK-------------YEVVYPIRLHPLRK-----RETQEPEP----- 51

  Fly    97 PHDDSGFNRGRTKKHFHRTSLLIK-AFNHKFR-LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHD 159
                         |....|.|..| ..|.|.. |.|:.|::||:|:..:.:|:..|..|..:...
Mouse    52 -------------KETFETELRYKMTVNGKVAVLYLKKNNKLLAPDYSETYYNSSGNKVTTSPQI 103

  Fly   160 IEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGC 224
            ::.|||.|.:.:...::|:..||.|:.|.|..|:|.:.|.|....:|.:..|.:|:..:..::..
Mouse   104 MDSCYYQGHIVNEKVSAASISTCQGLRGYISQGDEKYFIEPLSSENLDEQAHALFKDDSNEDQEK 168

  Fly   225 ANSGNLDS-WRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNG 288
            :|.|..|: |     .:.|...||.....:::...|.    |:|..||||..:::|...|.|.|
Mouse   169 SNCGVDDALW-----LQGLHQDVALPATRLIKLNDGM----VQEPKKYIEYYVVLDNGEFKKYN- 223

  Fly   289 STRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSK-----DISKAISNFNDYT 348
            ...||:....:::||..::.:..|:..|::|.:|.|      .||.|     |.:..:.||:.:.
Mouse   224 KNLAEIRKIVLEMANYINMLYNKLDAHVALVGVEIW------TDGDKIKITPDANTTLENFSKWR 282

  Fly   349 SRNLFQIE-RDTTQLLTGETFAGGEAGMAVPETVCTP-RAVGISVDVNVYEPHL-LAGTMAHMIG 410
            ..:|.:.: .|..||::...|:|...|:|...::|:| .:|||..|.:.|  || :||||||.:|
Mouse   283 GNDLLKRKHHDIAQLISSTDFSGSTVGLAFMSSMCSPYHSVGIVQDHSNY--HLRVAGTMAHEMG 345

  Fly   411 HNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNK--P 473
            ||:||.||  ...|.|.. ..|:|.||:   ....|..||.||:.:|...|......||.|.  |
Mouse   346 HNLGMIHD--YLSCKCPS-EVCVMEQSL---RFHMPTDFSSCSRVNYKQFLEEKLSHCLFNSPLP 404

  Fly   474 NEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYIC 538
            ::|.....|||:::|.:|:|||||.:||. ::|||..|||:|:..|||.|.||::|:|:....:|
Mouse   405 SDIISTPVCGNQLLEMNEDCDCGTPKECT-NKCCDARTCKIKAGFQCALGECCEKCQLKKPGVVC 468

  Fly   539 RDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSA 603
            |.:.:||||||.|||:...||.|.|:.|||||   :.| .|||.:|.||||..||..:||.|...
Mouse   469 RAAKDECDLPEVCDGKSSHCPGDRFRVNGSPC---QNG-HGYCLKGKCPTLQQQCMDMWGPGTKV 529

  Fly   604 ADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISI 668
            |:..||:| |..|:..|:|..:...| :.|:.::..||.|.|:.|.......|:      ||..:
Mouse   530 ANTSCYKQ-NEGGTKYGYCHVENGTH-MPCKAKDAMCGKLFCEGGSGDLPWKGL------TISFL 586

  Fly   669 KGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSE 733
            ..:.|:.:.||..|        .:|.:||.||.|.:|:|..||.:    ::|...||... :|..
Mouse   587 TCKLFDPEDTSQGV--------DMVANGTKCGTNKVCINAECVDM----EKTYKSANCSS-KCKG 638

  Fly   734 HGVCTNTNRCFCDMGWGGNDCSS 756
            |.||.:..:|.|..||...||.:
Mouse   639 HAVCDHELQCQCKEGWAPPDCEN 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	31/108 (29%)
		Reprolysin	270..473	CDD:279729	69/212 (33%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	68/208 (33%)
		Disintegrin	488..562	CDD:278623	37/73 (51%)
		ACR	566..713	CDD:214743	51/146 (35%)
Adam28	NP_034212.1	Pep_M12B_propep	42..156	CDD:279848	35/136 (26%)
		Cysteine switch. /evidence=ECO:0000250	169..176		2/6 (33%)
		Reprolysin	206..402	CDD:279729	69/210 (33%)
		ZnMc_adamalysin_II_like	206..400	CDD:239797	68/208 (33%)
		Disintegrin	419..491	CDD:278623	37/72 (51%)
		ACR	496..623	CDD:214743	51/146 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..759
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950