Protein Alignment mmd and Adam9

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_001257925.1
• Gene: Adam9 / 11502
• MGIID: 105376
• Length: 863
• Species: Mus musculus
• Alignment Length: 845
• Identity: 261/845 - (30%)
• Similarity: 371/845 - (43%)
• Gaps: 185/845 - (21%)

  Fly    65 YQIIYPVQL--RHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFR 127
            |:||.|.:|  ...|.:|.|::::                             |.:|:|...:..
Mouse    43 YEIITPWRLTRERREALGPSSQQI-----------------------------SYVIQAQGKQHI 78

  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
            :.||.|:.||..:.....|...|.|:..:.:...||:|.|.|:....::.|...|.|:.|::|:.
Mouse    79 IHLERNTDLLPNDFVVYTYDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLE 143

  Fly   193 NETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAG 257
            |.:|.|.|.:.   |.|    ||                         |:...:.|:.:|.|:.|
Mouse   144 NASFGIEPLHN---SSH----FE-------------------------HIFYPMDGIHQEPLRCG 176

  Fly   258 VG-----------------------RNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAI 299
            |.                       |.:|.|...|:|:|..|:|||..:|.. |..:..|..:.|
Mouse   177 VSNRDTEKEGTQGDEEEHPSVTQLLRRRRAVLPQTRYVELFIVVDKERYDMM-GRNQTAVREEMI 240

  Fly   300 QVANIADLYFRTLNTRVSVVYIETWGKNQA--VIDGSKDISKAISNFNDYTSRNLFQIER---DT 359
            ::||..|..:..||.|:.:|.:|.|.....  :|.|:.|:   :.||..:  |..|.|.|   |:
Mouse   241 RLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDV---LGNFVQW--REKFLITRWRHDS 300

  Fly   360 TQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVY---EPHLLAGTMAHMIGHNIGMGHDDGR 421
            .||:..:.| ||.||||...|||:....|   .:||:   .....|..:||.:|||:||.|||||
Mouse   301 AQLVLKKGF-GGTAGMAFVGTVCSRSHAG---GINVFGQITVETFASIVAHELGHNLGMNHDDGR 361

  Fly   422 EECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLN--KPNEIELRRNCGN 484
             |||| ....|||.....|..|     ||.||.:|:........|.||||  ||:|.....:|||
Mouse   362 -ECFC-GAKSCIMNSGASGSRN-----FSSCSAEDFEKLTLNKGGSCLLNIPKPDEAYSAPSCGN 419

  Fly   485 KVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPE 549
            |:|:..|||||||.:||.:|.||:|.||||||.|:||.|.||..|:..|...:||...:|||:||
Mouse   420 KLVDPGEECDCGTAKECEVDPCCEGSTCKLKSFAECAYGDCCKDCQFLPGGSMCRGKTSECDVPE 484

  Fly   550 YCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNS 614
            ||:|....||.|||.:||.||..||    .||:.|.|.....||:.|:|....||.|.|:.:.||
Mouse   485 YCNGSSQFCPPDVFIQNGYPCQNSK----AYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNS 545

  Fly   615 KGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATS 679
            ||...|:||...:| |.||...|..||.|||::.:..||...:.     .||....:..:|....
Mouse   546 KGDRFGNCGFSGSE-YKKCATGNALCGKLQCENVQDMPVFGIVP-----AIIQTPSRGTKCWGVD 604

  Fly   680 GQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCF 744
            .|:||: .|:.|:|.:||.|....||.|..||:  ..|....|  :.|| :|..||||.:...|.
Mouse   605 FQLGSD-VPDPGMVNEGTKCDAGKICRNFQCVN--ASVLNYDC--DIQG-KCHGHGVCNSNKNCH 663

  Fly   745 CDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTS-----DQNRISTLT---MVII 801
            |:.||....|.:                          ..||.|     ..|..||..   :::.
Mouse   664 CEDGWAPPHCDT--------------------------KGYGGSVDSGPTYNAKSTALRDGLLVF 702

  Fly   802 LTVIVKCV------FISFATLAVCYRRKTTTLK------------YDPPYSKKP----IAKSYGG 844
            ..:||..|      ||....|...:|:|.:.:.            .||..|:.|    :::..||
Mouse   703 FFLIVPLVAAAIFLFIKRDELRKTFRKKRSQMSDGRNQANVSRQPGDPSISRPPGGPNVSRPPGG 767

  Fly   845  844
            Mouse   768  767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	27/109 (25%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	74/208 (36%)
		Disintegrin	488..561	CDD:459709	39/72 (54%)
		ACR	566..713	CDD:214743	54/146 (37%)
Adam9	NP_001257925.1	Pep_M12B_propep	44..163	CDD:460254	37/179 (21%)
		Reprolysin	212..406	CDD:426256	76/210 (36%)
		Disintegrin	423..496	CDD:459709	39/72 (54%)
		ACR	500..636	CDD:214743	53/146 (36%)
		EGF_2	650..673	CDD:400365	9/22 (41%)
		Drf_FH1	<747..820	CDD:461881	6/21 (29%)