DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam9

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001257925.1	Gene:	Adam9 / 11502	MGIID:	105376	Length:	863	Species:	Mus musculus

Alignment Length:	845	Identity:	261/845 - (30%)
Similarity:	371/845 - (43%)	Gaps:	185/845 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YQIIYPVQL--RHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFR 127
            |:||.|.:|  ...|.:|.|::::                             |.:|:|...:..
Mouse    43 YEIITPWRLTRERREALGPSSQQI-----------------------------SYVIQAQGKQHI 78

  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
            :.||.|:.||..:.....|...|.|:..:.:...||:|.|.|:....::.|...|.|:.|::|:.
Mouse    79 IHLERNTDLLPNDFVVYTYDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLE 143

  Fly   193 NETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAG 257
            |.:|.|.|.:.   |.|    ||                         |:...:.|:.:|.|:.|
Mouse   144 NASFGIEPLHN---SSH----FE-------------------------HIFYPMDGIHQEPLRCG 176

  Fly   258 VG-----------------------RNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAI 299
            |.                       |.:|.|...|:|:|..|:|||..:|.. |..:..|..:.|
Mouse   177 VSNRDTEKEGTQGDEEEHPSVTQLLRRRRAVLPQTRYVELFIVVDKERYDMM-GRNQTAVREEMI 240

  Fly   300 QVANIADLYFRTLNTRVSVVYIETWGKNQA--VIDGSKDISKAISNFNDYTSRNLFQIER---DT 359
            ::||..|..:..||.|:.:|.:|.|.....  :|.|:.|:   :.||..:  |..|.|.|   |:
Mouse   241 RLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDV---LGNFVQW--REKFLITRWRHDS 300

  Fly   360 TQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVY---EPHLLAGTMAHMIGHNIGMGHDDGR 421
            .||:..:.| ||.||||...|||:....|   .:||:   .....|..:||.:|||:||.|||||
Mouse   301 AQLVLKKGF-GGTAGMAFVGTVCSRSHAG---GINVFGQITVETFASIVAHELGHNLGMNHDDGR 361

  Fly   422 EECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLN--KPNEIELRRNCGN 484
             |||| ....|||.....|..|     ||.||.:|:........|.||||  ||:|.....:|||
Mouse   362 -ECFC-GAKSCIMNSGASGSRN-----FSSCSAEDFEKLTLNKGGSCLLNIPKPDEAYSAPSCGN 419

  Fly   485 KVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPE 549
            |:|:..|||||||.:||.:|.||:|.||||||.|:||.|.||..|:..|...:||...:|||:||
Mouse   420 KLVDPGEECDCGTAKECEVDPCCEGSTCKLKSFAECAYGDCCKDCQFLPGGSMCRGKTSECDVPE 484

  Fly   550 YCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNS 614
            ||:|....||.|||.:||.||..||    .||:.|.|.....||:.|:|....||.|.|:.:.||
Mouse   485 YCNGSSQFCPPDVFIQNGYPCQNSK----AYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNS 545

  Fly   615 KGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATS 679
            ||...|:||...:| |.||...|..||.|||::.:..||...:.     .||....:..:|....
Mouse   546 KGDRFGNCGFSGSE-YKKCATGNALCGKLQCENVQDMPVFGIVP-----AIIQTPSRGTKCWGVD 604

  Fly   680 GQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCF 744
            .|:||: .|:.|:|.:||.|....||.|..||:  ..|....|  :.|| :|..||||.:...|.
Mouse   605 FQLGSD-VPDPGMVNEGTKCDAGKICRNFQCVN--ASVLNYDC--DIQG-KCHGHGVCNSNKNCH 663

  Fly   745 CDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTS-----DQNRISTLT---MVII 801
            |:.||....|.:                          ..||.|     ..|..||..   :::.
Mouse   664 CEDGWAPPHCDT--------------------------KGYGGSVDSGPTYNAKSTALRDGLLVF 702

  Fly   802 LTVIVKCV------FISFATLAVCYRRKTTTLK------------YDPPYSKKP----IAKSYGG 844
            ..:||..|      ||....|...:|:|.:.:.            .||..|:.|    :::..||
Mouse   703 FFLIVPLVAAAIFLFIKRDELRKTFRKKRSQMSDGRNQANVSRQPGDPSISRPPGGPNVSRPPGG 767

Fly 845 844
Mouse 768 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	27/106 (25%)
		Reprolysin	270..473	CDD:279729	76/212 (36%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	74/208 (36%)
		Disintegrin	488..562	CDD:278623	39/73 (53%)
		ACR	566..713	CDD:214743	54/146 (37%)
Adam9	NP_001257925.1	Pep_M12B_propep	55..160	CDD:279848	32/165 (19%)
		Reprolysin	212..406	CDD:279729	76/210 (36%)
		ZnMc_adamalysin_II_like	212..404	CDD:239797	74/208 (36%)
		Disintegrin	423..497	CDD:278623	39/73 (53%)
		ACR	500..636	CDD:214743	53/146 (36%)
		Drf_FH1	<747..820	CDD:283903	6/21 (29%)
		Collagen	755..810	CDD:189968	3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6972
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5934
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.000