DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam8

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_017177421.1	Gene:	Adam8 / 11501	MGIID:	107825	Length:	876	Species:	Mus musculus

Alignment Length:	815	Identity:	235/815 - (28%)
Similarity:	357/815 - (43%)	Gaps:	163/815 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YQIIYPVQLRHHEKMGISTREVSLPKP-GQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRL 128
            |::::|      .::..|....:||.. ||.|                 ...|..:....|.|.|
Mouse    27 YEVVWP------RRLAASRSRRALPSHWGQYP-----------------ESLSYALGTSGHVFTL 68

  Fly   129 DLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGN 193
            .|..|..||..:..:.:....|..|.....:.:||.|.|.|:.|.|::|:..||.|:.|...:|:
Mouse    69 HLRKNRDLLGSSYTETYSAANGSEVTEQLQEQDHCLYQGHVEGYEGSAASISTCAGLRGFFRVGS 133

  Fly   194 ETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHL--SAGVAGVVE----- 251
            ...:|.|....:  :..|.:::|                       |||  .||..||.:
Mouse   134 TVHLIEPLDADE--EGQHAMYQA-----------------------KHLQQKAGTCGVKDTNLND 173

  Fly   252 ------EILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFR 310
                  ||.:| ..||....|| |:|:|..::.|...|.|.  .:|..|....::|.|..|..::
Mouse   174 LGPRALEIYRA-QPRNWLIPRE-TRYVELYVVADSQEFQKL--GSREAVRQRVLEVVNHVDKLYQ 234

  Fly   311 TLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAGGEAG 374
            .|:.||.:|.:|.|.|::..|  |:..:..:.||..:..:|| .|...|..||:||..|.|...|
Mouse   235 ELSFRVVLVGLEIWNKDKFYI--SRYANVTLENFLSWREQNLQGQHPHDNVQLITGVDFIGSTVG 297

  Fly   375 MAVPETVCTPRAVGISVDVNVYEPHL-----LAGTMAHMIGHNIGMGHDDGREECFC---RDWHG 431
            :|....:|:..:..::.|      |.     :|.||||.:|||:||.||:....|:|   |:..|
Mouse   298 LAKVSALCSRHSGAVNQD------HSKNSIGVASTMAHELGHNLGMSHDEDIPGCYCPEPREGGG 356

  Fly   432 CIMAQSIVGQENVQPYKFSECSKKD---YIDALRTGHGLCLLNKP--NEIELRRNCGNKVVEEDE 491
            |||.:||..:   .|..||.|||.|   ::...:||   ||.|.|  |.......|||..||..|
Mouse   357 CIMTESIGSK---FPRIFSRCSKIDLESFVTKPQTG---CLTNVPDVNRFVGGPVCGNLFVEHGE 415

  Fly   492 ECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIG 556
            :|||||.::|. :.||:..||:|...|:||||.||.:|:::|...:||.|.::|||.|:|||...
Mouse   416 QCDCGTPQDCQ-NPCCNATTCQLVKGAECASGTCCHECKVKPAGEVCRLSKDKCDLEEFCDGRKP 479

  Fly   557 QCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSING- 620
            .||.|.|::||:||.      .||||.|.||||:.||..:||.|...|...|| .|:.....||
Mouse   480 TCPEDAFQQNGTPCP------GGYCFDGSCPTLAQQCRDLWGPGARVAADSCY-TFSIPPGCNGR 537

  Fly   621 -HCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGS 684
             :.|| .|           :||.|.|:.|:: |:        .|:..:.......|.|..  .||
Mouse   538 MYSGR-IN-----------RCGALYCEGGQK-PL--------ERSFCTFSSNHGVCHALG--TGS 579

  Fly   685 NSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGW 749
            | .....||..||.|.:..:|::.:|..|..:..: .|.|     :|:.||||.:...|.|..||
Mouse   580 N-IDTFELVLQGTKCEEGKVCMDGSCQDLRVYRSE-NCSA-----KCNNHGVCNHKRECHCHKGW 637

  Fly   750 GGNDC-------------SSVVLLTTALPTEALPTPENTIKMEK-----------KETPYGTSDQ 790
            ...:|             ||..::|.:....:.....|.:.:..           ...|...|.:
Mouse   638 APPNCVQRLADVSDEQAVSSFPVVTESAAVHSTTASGNWLGLNSGIVGLGLTTTTSSNPLLESQK 702

  Fly   791 NRIST---LTMVIILTVIVKCVFISFATLAVCYRR 822
            :..||   :::|::|.::|..:.|  ....|.||:
Mouse   703 SWSSTSLPVSVVVVLVILVAAMVI--VAGIVIYRK 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	26/106 (25%)
		Reprolysin	270..473	CDD:279729	69/214 (32%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	68/212 (32%)
		Disintegrin	488..562	CDD:278623	34/73 (47%)
		ACR	566..713	CDD:214743	46/148 (31%)
Adam8	XP_017177421.1	Pep_M12B_propep	28..152	CDD:366707	33/148 (22%)
		Reprolysin	196..395	CDD:366632	69/214 (32%)
		DISIN	412..486	CDD:214490	35/74 (47%)
		ACR	488..607	CDD:214743	46/149 (31%)
		PHA03247	<638..857	CDD:223021	16/100 (16%)
		Rib_recp_KP_reg	<771..856	CDD:368286
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950