Protein Alignment mmd and Adam7

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_031428.2
• Gene: Adam7 / 11500
• MGIID: 107247
• Length: 789
• Species: Mus musculus
• Alignment Length: 904
• Identity: 226/904 - (25%)
• Similarity: 380/904 - (42%)
• Gaps: 157/904 - (17%)

  Fly    62 GHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKF 126
            |.::..:....::....:|:..:|:..||  :.|..|.       |..:..| .|.:.:.:..:.
Mouse     5 GIFWMTVLISHIQERGIVGVEGQELVHPK--KLPLLHK-------RDLERIH-DSDIPEEYEEEL 59

  Fly   127 RLDLELNS-----------QLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFH 180
            ..:::|..           :.||.|..:.:|:|...:...:...::||:|.|::.....::|:..
Mouse    60 LYEIKLGKKTLILHLLKAREFLSSNYSETYYNVKREVFTKHPQILDHCFYQGSIIHEFDSAASIS 124

  Fly   181 TCNGVSGVIHIGNETFVIHPF-YGGDLSKHPHVIFEARTKA----NKGCANSGNLDSWRLSRRTK 240
            ||||:.|...:.::.::|.|. |..|   ..|::::...||    |..|..        |:...|
Mouse   125 TCNGLRGFFRVNDQRYLIEPVKYSDD---GEHLVYKYNVKAPYATNHSCVG--------LNFTKK 178

  Fly   241 HLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIA 305
            .....|..:.|        .|..| ....|:||..::.|:.:: :||...:.::......:.|..
Mouse   179 SALIDVENIEE--------HNAED-HHKEKFIELFVVADEYVY-RRNNKPQNKLRKRIWGMVNFV 233

  Fly   306 DLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFA 369
            ::.::|||..|::...|.|..... |:...::...:.:|:.:....| .:.:.|...||:|:...
Mouse   234 NMIYKTLNIHVTLAGFEIWSAGDK-IEIVSNLESTLLHFSTWQETVLKKRKDFDHVILLSGKWLY 297

  Fly   370 GGEAGMAVPETVC-TPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCI 433
            ....|:|.|..:| ..|:..:..|: :.:.:::...|||.:||::||.||.  ..|.|.
Mouse   298 TSMQGIAYPGGICQILRSCSVVKDL-LPDVNIIGNRMAHQLGHSLGMQHDG--FPCTCP------ 353

  Fly   434 MAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNK--PNEIELRRNCGNKVVEEDEECDCG 496
            :.:.::|..::...|||:||:..|...|:.....|:||.  |.|......||||.|:|.||||||
Mouse   354 LGKCVMGDGSIPAIKFSKCSQTQYQQFLQDQKPACILNNPFPEEFNDYPFCGNKKVDEGEECDCG 418

  Fly   497 TFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSD 561
            ..:||. :.|||...|.||....|..|.||:.|:::.:..:||.:.||||:.|.|.|...:||.|
Mouse   419 PVQECT-NPCCDAHKCVLKPGFTCVEGECCESCQMKKEGAVCRLAKNECDISEVCTGYSPECPKD 482

  Fly   562 VFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDA 626
            .|:.||.||   :.| .||||.|.|||.:.||..::..|...:...|| :.|.||:..|:|....
Mouse   483 EFQANGFPC---RNG-EGYCFMGLCPTRNEQCSELFIGGAEESHSLCY-RMNKKGNRFGYCKNKG 542

  Fly   627 NEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHG 691
            |. ::.||.::::||.:.|..| |.....|.|:.|:  :.::| |....|..:..:..|| .:.|
Mouse   543 NT-FVPCEEKDLKCGKIYCSGG-RPSSRLGEDKAYN--LKNVK-QNVTIKCRTMFLHHNS-RDMG 601

  Fly   692 LVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMG-----WGG 751
            ||..||.|||.::|.|..|:.:....:.|.|.:     .|.|:.|..|...|.|:.|     ||
Mouse   602 LVNSGTKCGDGMVCSNGECIEMEKAYNSTICSS-----PCDENDVDDNEPECQCEEGSIITEWG- 660

  Fly   752 NDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATL 816
                           |||                     |..|...|||:|.:::  :.:....|
Mouse   661 ---------------EAL---------------------NLTSVSIMVIVLVMVI--IGVGLVIL 687

  Fly   817 AVCYRR--KTTTLKYDPPYSKKPIAKSYGGAATAPNHHSV--EEVSLDGSSKLVYANQTGFRDKG 877
            .:.|::  |...::..|...:....|.|     .|..|..  |.:..|
Mouse   688 LIRYQKCIKMKQVQSSPREIRGVENKGY-----FPEEHQTRSEPILTD----------------- 730

  Fly   878 IHGRRYTTCGEDDQSHAEKGILKKHGYGLVHGEQLKDKWG--DDNQSD--NLELITQDG 932
            ||....|.   :............|...|  ....||..|  |..|:|  ||.|.||.|
Mouse   731 IHPLHTTA---ESLERVPSSFSSPHYITL--KSVSKDSRGIADPKQTDNVNLNLDTQSG 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	24/121 (20%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	46/202 (23%)
		Disintegrin	488..561	CDD:459709	31/72 (43%)
		ACR	566..713	CDD:214743	50/146 (34%)
Adam7	NP_031428.2	Pep_M12B_propep	28..156	CDD:460254	29/140 (21%)
		Reprolysin	199..393	CDD:426256	48/204 (24%)
		Disintegrin	410..482	CDD:459709	31/72 (43%)
		ACR	486..623	CDD:214743	50/147 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..789		10/21 (48%)