DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam5

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001258987.1	Gene:	Adam5 / 11499	MGIID:	104730	Length:	771	Species:	Mus musculus

Alignment Length:	848	Identity:	207/848 - (24%)
Similarity:	341/848 - (40%)	Gaps:	212/848 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LLIKAFNH-----------KFRLDLELNSQLLSPNIQQKHYHVGGYLVDGN-------------- 156
            ||:..|.|           |..|...:..::.||:::........||:..|
Mouse     3 LLLLLFLHLKGLQAGQNPQKTTLQTTVPEKISSPDVETDAEDHMAYLITINETPHFIHLKKQSFI 67

  Fly   157 ----------RHDIEH---------CYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFY 202
                      |:|::|         |.|:|.|..:|.:......|.|:.|:|...|.::.|.|.
Mouse    68 TPTAVVYTYDRNDVQHSQPLSALENCNYNGYVAGFPNSIVTLTVCTGLRGIIQFENVSYAIEPV- 131

  Fly   203 GGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRN------ 261
             ..||...|||:|                     ...||      .|:.::     |:|
Mouse   132 -ETLSGFVHVIYE---------------------NTNKH------AVIPDL-----GKNQSYSWF 163

  Fly   262 -------KRDVREA------TKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLN 313
                   :.:::::      .::|...|||||.:||.. ||....|:...||:....:.....|.
Mouse   164 DESDYQFRSNMKKSGFTVLRQRFIMMDIIVDKKLFDYM-GSDTEVVLQKVIQIIGFVNTMLSKLK 227

  Fly   314 TRVSVVYIETWGKNQAVIDGSKDISKAISNF--------NDYTSRNL-FQIERDTTQLLTGETFA 369
            ..|.:..||.|.|...:     .:|||:.:.        ::|.|::: :.:..:.....||..:.
Mouse   228 LTVLINSIEIWSKENRI-----RLSKAVDDLLVQFSIWKHEYRSQHVAYLLAFEEHPASTGALYP 287

  Fly   370 GGEAGMAVPETVCT-PRAVGISVD-VNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGC 432
            |....:.....|.. |:  |:|:: .:|....||          :||||.....|.|.|.. ..|
Mouse   288 GNLCKLEYNAAVALYPK--GLSLESFSVIVLQLL----------SIGMGLTYDTENCHCTG-EVC 339

  Fly   433 IMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGL-CLLNKPNEIE----LRRNCGNKVVEEDEE 492
            :|....:....|:  .||.|:..|: ..|.|...| ||.:.|.|.:    .||.|||.::|.:|:
Mouse   340 LMTPKAIYSGGVK--DFSTCTLDDF-KYLSTRQDLRCLQDLPLERKPARRPRRICGNGILEMNEQ 401

  Fly   493 CDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQ-CRLRPKDYICRDSNNECDLPEYCDGEIG 556
            |||||.:.|...:|||.::|:||::|.|.||.||.| |.::..|.:||.|.:|||..|||:|:..
Mouse   402 CDCGTLKNCTHRKCCDPMSCRLKNKATCGSGECCSQDCTVKMNDVVCRKSVDECDFVEYCNGKDP 466

  Fly   557 QCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGH 621
            .|..:.:.:||..|   ::| ..:||:|.|.|...||.::.|.....|...|||:|||:|...|:
Mouse   467 YCVPNTYARNGQYC---ESG-EAFCFEGRCQTADKQCMSMLGKYVRGASFACYEEFNSRGDRFGN 527

  Fly   622 CGRDANEHYIKCEPENVQCGTLQCK-DGERQPVNDGIDQLYSR-----TIISIKGQEFECKATSG 680
            |..:.      |...|..||.|.|. ..::..:...:...|::     .:...||.... |.|..
Mouse   528 CIHNF------CAFRNSLCGKLICTWPFKKLVLKANLSVAYAQIRDDLCVAMYKGGRIP-KTTKT 585

  Fly   681 QVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFC 745
            ...:.:..:...|.|||.||.::.||..:|.....|:|.:||.:..   :|::||||.|...|.|
Mouse   586 TYSNPADRDETFVNDGTICGPDMFCLRASCTETRFHMDSSKCDSTR---DCNDHGVCNNLQHCHC 647

  Fly   746 DMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSD--------------------- 789
            |:|:....|                        |:.:..:|:.|
Mouse   648 DIGYNPPFC------------------------EEHKGQFGSVDDGHKYHVEDGKSYKQQSHSNL 688

  Fly   790 -QNRISTLTMVII-LTVIVKCVFISFATLA-VCYRRK-----TTTLKYDPPYSKKPIAKSYGGAA 846
             :|::..:..:.: |.|::..|.|..:.|: ||.|.:     :||   :...|...:..|.|.::
Mouse   689 KKNQLQLILYISLPLLVMISAVVIKQSKLSRVCDRERSESDSSTT---EDSGSNTNVTSSGGSSS 750

  Fly   847 TAP 849
            |.|
Mouse   751 TDP 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	29/139 (21%)
		Reprolysin	270..473	CDD:279729	53/214 (25%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	53/212 (25%)
		Disintegrin	488..562	CDD:278623	34/74 (46%)
		ACR	566..713	CDD:214743	42/152 (28%)
Adam5	NP_001258987.1	Pep_M12B_propep	35..141	CDD:279848	23/107 (21%)
		Reprolysin	185..378	CDD:279729	53/214 (25%)
		ZnMc_adamalysin_II_like	185..376	CDD:239797	53/212 (25%)
		DISIN	397..473	CDD:214490	34/75 (45%)
		ACR	475..618	CDD:214743	42/153 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920