Protein Alignment mmd and Adam4

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_033750.1
• Gene: Adam4 / 11498
• MGIID: 104731
• Length: 763
• Species: Mus musculus
• Alignment Length: 811
• Identity: 218/811 - (26%)
• Similarity: 327/811 - (40%)
• Gaps: 169/811 - (20%)

  Fly    74 RHHEKMGISTREVSLP-KPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFR-----LDLEL 132
            |...|...||.|:.:| |..||....|.||          |.|      ::.:||     :.::|
Mouse    35 RSPPKWRFSTSEIVIPRKVPQRMGKSDMSG----------HIT------YSMRFRGQRHVVHMKL 83

  Fly   133 NSQLLSPNI----------QQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC-NGVS 186
            ...::..|.          |||.|....          ..||::..::..||:.|...|| .|:.
Mouse    84 KKNMIPQNFPVYTSNDQGAQQKDYPFVP----------RDCYFYSFLEGVPGSQAILDTCTGGLK 138

  Fly   187 GVIHIGNETFVIHPFYGGDLSKHPHVI----FEARTKANKGCANSGNLDSWRLSRRTKHLSAGVA 247
            |:|.:.:.|:.|.|.  ...||..|||    .:.|::.:|.|.|.             .:.|...
Mouse   139 GMIQVDDFTYEIKPL--ASSSKFEHVISLLVVDERSRESKKCRND-------------EIMAKAG 188

  Fly   248 GVVEEILQAGVGRNKRDVREATKY----------IETAIIVDKAMFDKRNGSTRAEVIHDAIQVA 302
            .:.||...||      ..|.|..|          |...:..|.......|.||..|:|   :.:.
Mouse   189 DLSEETKLAG------SPRAAPVYLWRYHLKSVGIHYTVTHDLFKQTGSNSSTSVELI---LIMN 244

  Fly   303 NIADLYFRTLNTRVSVVYIETWG-KNQAVIDGSK---DISKAISNFNDYTSRNLFQIERDTTQLL 363
            :|:|..::.....|....:..|. ||...:.|..   |....::.|..:.|:.|..:...|..||
Mouse   245 SISDSIYKISGLIVYARGVWIWNTKNLHTVPGENPHLDPWSVMAGFGVWKSKELHDLYATTAILL 309

  Fly   364 TGE-------TFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHL-LAGT-MAHMIGHNIGMGHDD 419
            ...       :|..|         :|.|. .|: :...|.:.|| |||: :||.:||.:.:.||.
Mouse   310 ASRPKNTDYGSFQNG---------LCNPN-WGV-LFTYVGKNHLFLAGSFLAHAVGHLLDVSHDT 363

  Fly   420 GREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGL--CL---LNKPNEIELR 479
            ....||.|.  .|:|.:.....:.:     |.||   :.:..|..|..  ||   |....|:.:.
Mouse   364 PGCVCFRRS--SCLMDEFPTLHDMI-----SNCS---HNELHRRIHDWDPCLSLELKTAKEVNMY 418

  Fly   480 R--NCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSN 542
            .  .||||.||..|:||||:.::|..|:||: :.|:....:.||:|.||..|:..|...||||.|
Mouse   419 EVPRCGNKRVEASEKCDCGSVKDCTTDKCCE-VNCEFTQGSSCAAGGCCLSCKFAPTGTICRDKN 482

  Fly   543 NECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQ 607
            ..|||||||.|....||.:.:..:|:||  |...:   |..|.|....|||:|::||........
Mouse   483 GICDLPEYCSGASEHCPGNFYIMDGTPC--SPLAV---CIAGNCSDRHLQCQALFGYQVKDGSPA 542

  Fly   608 CYEQFNSKGSINGHCG----RDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQL-------- 660
            ||.:.|.||...|:||    |..::. :.|:.|:|.||.:.|         ||:..:
Mouse   543 CYNELNVKGDRFGNCGIRIIRGGSQP-VPCQKEDVFCGMIHC---------DGVSHIPGGGEHTT 597

  Fly   661 -YSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPA 724
             |...:..:|  |.:|.......|: ..||.|||.||..||....|..|.||: .|.:: ..|..
Mouse   598 FYHLKVQDVK--EEQCFGYDAHHGT-ELPEMGLVVDGATCGPGKYCKAQRCVA-HPTLN-FNCNI 657

  Fly   725 NSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSD 789
            :|    |:..|||.|...|.|..||....|   :.:.....|.:.| |..|.|..:.|.....:.
Mouse   658 SS----CNFRGVCNNKGNCHCVRGWQPPHC---LQIGKGGSTNSGP-PPTTQKKHQAEIHVSANR 714

  Fly   790 QNRISTLTMVIILTVIV-----KCVFISFAT 815
            ...|.::.|::||..|:     |.:|:|..|
Mouse   715 LIVILSIRMILILASILLGAVFKAIFVSETT 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	28/129 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	51/228 (22%)
		Disintegrin	488..561	CDD:459709	33/72 (46%)
		ACR	566..713	CDD:214743	48/159 (30%)
Adam4	NP_033750.1	Pep_M12B_propep	46..163	CDD:460254	34/144 (24%)
		ZnMc_adamalysin_II_like	213..406	CDD:239797	49/216 (23%)
		DISIN	429..503	CDD:214490	33/74 (45%)
		ACR	505..648	CDD:214743	48/161 (30%)