DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam4

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_033750.1	Gene:	Adam4 / 11498	MGIID:	104731	Length:	763	Species:	Mus musculus

Alignment Length:	811	Identity:	218/811 - (26%)
Similarity:	327/811 - (40%)	Gaps:	169/811 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RHHEKMGISTREVSLP-KPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFR-----LDLEL 132
            |...|...||.|:.:| |..||....|.||          |.|      ::.:||     :.::|
Mouse    35 RSPPKWRFSTSEIVIPRKVPQRMGKSDMSG----------HIT------YSMRFRGQRHVVHMKL 83

  Fly   133 NSQLLSPNI----------QQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC-NGVS 186
            ...::..|.          |||.|....          ..||::..::..||:.|...|| .|:.
Mouse    84 KKNMIPQNFPVYTSNDQGAQQKDYPFVP----------RDCYFYSFLEGVPGSQAILDTCTGGLK 138

  Fly   187 GVIHIGNETFVIHPFYGGDLSKHPHVI----FEARTKANKGCANSGNLDSWRLSRRTKHLSAGVA 247
            |:|.:.:.|:.|.|.  ...||..|||    .:.|::.:|.|.|.             .:.|...
Mouse   139 GMIQVDDFTYEIKPL--ASSSKFEHVISLLVVDERSRESKKCRND-------------EIMAKAG 188

  Fly   248 GVVEEILQAGVGRNKRDVREATKY----------IETAIIVDKAMFDKRNGSTRAEVIHDAIQVA 302
            .:.||...||      ..|.|..|          |...:..|.......|.||..|:|   :.:.
Mouse   189 DLSEETKLAG------SPRAAPVYLWRYHLKSVGIHYTVTHDLFKQTGSNSSTSVELI---LIMN 244

  Fly   303 NIADLYFRTLNTRVSVVYIETWG-KNQAVIDGSK---DISKAISNFNDYTSRNLFQIERDTTQLL 363
            :|:|..::.....|....:..|. ||...:.|..   |....::.|..:.|:.|..:...|..||
Mouse   245 SISDSIYKISGLIVYARGVWIWNTKNLHTVPGENPHLDPWSVMAGFGVWKSKELHDLYATTAILL 309

  Fly   364 TGE-------TFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHL-LAGT-MAHMIGHNIGMGHDD 419
            ...       :|..|         :|.|. .|: :...|.:.|| |||: :||.:||.:.:.||.
Mouse   310 ASRPKNTDYGSFQNG---------LCNPN-WGV-LFTYVGKNHLFLAGSFLAHAVGHLLDVSHDT 363

  Fly   420 GREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGL--CL---LNKPNEIELR 479
            ....||.|.  .|:|.:.....:.:     |.||   :.:..|..|..  ||   |....|:.:.
Mouse   364 PGCVCFRRS--SCLMDEFPTLHDMI-----SNCS---HNELHRRIHDWDPCLSLELKTAKEVNMY 418

  Fly   480 R--NCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSN 542
            .  .||||.||..|:||||:.::|..|:||: :.|:....:.||:|.||..|:..|...||||.|
Mouse   419 EVPRCGNKRVEASEKCDCGSVKDCTTDKCCE-VNCEFTQGSSCAAGGCCLSCKFAPTGTICRDKN 482

  Fly   543 NECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQ 607
            ..|||||||.|....||.:.:..:|:||  |...:   |..|.|....|||:|::||........
Mouse   483 GICDLPEYCSGASEHCPGNFYIMDGTPC--SPLAV---CIAGNCSDRHLQCQALFGYQVKDGSPA 542

  Fly   608 CYEQFNSKGSINGHCG----RDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQL-------- 660
            ||.:.|.||...|:||    |..::. :.|:.|:|.||.:.|         ||:..:
Mouse   543 CYNELNVKGDRFGNCGIRIIRGGSQP-VPCQKEDVFCGMIHC---------DGVSHIPGGGEHTT 597

  Fly   661 -YSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPA 724
             |...:..:|  |.:|.......|: ..||.|||.||..||....|..|.||: .|.:: ..|..
Mouse   598 FYHLKVQDVK--EEQCFGYDAHHGT-ELPEMGLVVDGATCGPGKYCKAQRCVA-HPTLN-FNCNI 657

  Fly   725 NSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSD 789
            :|    |:..|||.|...|.|..||....|   :.:.....|.:.| |..|.|..:.|.....:.
Mouse   658 SS----CNFRGVCNNKGNCHCVRGWQPPHC---LQIGKGGSTNSGP-PPTTQKKHQAEIHVSANR 714

  Fly   790 QNRISTLTMVIILTVIV-----KCVFISFAT 815
            ...|.::.|::||..|:     |.:|:|..|
Mouse   715 LIVILSIRMILILASILLGAVFKAIFVSETT 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	26/122 (21%)
		Reprolysin	270..473	CDD:279729	52/230 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	51/228 (22%)
		Disintegrin	488..562	CDD:278623	33/73 (45%)
		ACR	566..713	CDD:214743	48/159 (30%)
Adam4	NP_033750.1	Pep_M12B_propep	60..163	CDD:279848	29/130 (22%)
		ZnMc_adamalysin_II_like	213..406	CDD:239797	49/216 (23%)
		Reprolysin	213..405	CDD:279729	48/215 (22%)
		DISIN	429..503	CDD:214490	33/74 (45%)
		ACR	505..648	CDD:214743	48/161 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850