DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam3

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_033749.2	Gene:	Adam3 / 11497	MGIID:	102518	Length:	822	Species:	Mus musculus

Alignment Length:	885	Identity:	209/885 - (23%)
Similarity:	350/885 - (39%)	Gaps:	187/885 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 RTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVD--GNRHDI-----EHCYYHGTVKD 171
            :.:.:::.....:.|.||..|.|        |...|.||.|  |.....     .||:|.|...:
Mouse    47 QVTYVVRIEGKAYTLQLEKQSFL--------HPLFGTYLRDKLGTLQPYFSLVKTHCFYQGHAAE 103

  Fly   172 YPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANK--------GCANS- 227
            .|.::....||:|:.|::.:.|.|:.|.|....  :...|:::|  .|.||        ..|||
Mouse   104 IPVSTVTLSTCSGLRGLLQLENITYGIEPLESS--ATFEHILYE--IKNNKIDYSPLKENFANSE 164

  Fly   228 GNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRN---GS 289
            ....|:|:                 :::...|.|....:   :.:...||:||||||...   |.
Mouse   165 QESQSYRI-----------------LVKPEKGSNSTLTK---RILRIKIIMDKAMFDHMGSEVGV 209

  Fly   290 TRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQ 354
            ...:|:|    :..:.:..|..|...|.:..:|.|.: |..|:.:.|..:.:..|..:.|:.:.|
Mouse   210 ATQKVVH----IFGLINTMFSQLKMTVMLNSLEIWSE-QDKIETNGDADEVLQRFLLWKSKEISQ 269

  Fly   355 IERDTTQLL--------TGETFAGGEAGMAVPETVCTPR-AVGISVDVNVYEPHLLAGTMAHMIG 410
            ..:|.|.||        .|.|:    .|||     |.|. ..||::..........|..::.::|
Mouse   270 KAQDITYLLLYKDHPDYVGATY----HGMA-----CNPNFTAGIALHPKTLAVEGFAIVLSQLLG 325

  Fly   411 HNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNE 475
            .|:|:.:|| ...||| ....|||..|.:..:.::  .||.||    :|..:.     |.::| |
Mouse   326 INLGLAYDD-VYNCFC-PGSTCIMNPSAIRSQGIK--VFSSCS----VDEFKQ-----LASQP-E 376

  Fly   476 IELRRN---------------CGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGAC 525
            ::..||               |||.::|..|:||||..|.|...:||:...|.|...|||.:|.|
Mouse   377 LDCLRNTSETEFVVQPQGGSYCGNHLLEVPEQCDCGPPETCTHKKCCNPKDCTLIDAAQCGTGPC 441

  Fly   526 CDQ--CRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPT 588
            ||:  |.:..:..:||.|.::||.||:|:||...|..|....:..||    ...:.|||.|.|..
Mouse   442 CDKRTCTIAERGRLCRKSKDQCDFPEFCNGETEGCAPDTKAADLEPC----NNETAYCFGGVCRD 502

  Fly   589 LSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHC-GRDANEHYIKCEPENVQCGTLQCKDGERQP 652
            ...||..::|......:..|.::.|.:....|:| ||        |....:.||...|
Mouse   503 PDRQCTDLFGKYAKGPNYVCAQEVNLQNDKFGNCHGR--------CNYSAIFCGKAVC------- 552

  Fly   653 VNDGIDQLYSRTIISIKGQEFECKAT--SGQVGSNSY-------PEHGLVKDGTPCGDNLICLNQ 708
                    |......|:.::::.:.|  .|||..:::       .:...|.|||.||...:|...
Mouse   553 --------YWNFAEVIQTEKYDVQYTYLGGQVCVSAHLRSQTGTRDDTYVHDGTVCGSGQVCFRG 609

  Fly   709 TCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEA----- 768
            .|:.:.......:|.|:.   :|..||:|.|.|.|.|:.|:...:|.    :|.:.|..:
Mouse   610 DCLRVHVLRGTRECEADD---KCQGHGICNNLNNCQCESGFAPPECD----MTPSSPGGSMDDGF 667

  Fly   769 -LPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKYDPP 832
             ||..::|..:.|:   :|.. ..::..::..|:|..:|...|:  |...:..:|
Mouse   668 WLPFDKSTPLIFKR---HGLK-YKKVLLISFYILLPFLVVLAFM--AVKRMIGKR---------- 716

  Fly   833 YSKKPIAKSYGGAATAPNHHSVEE--VSLDGSSKLVYANQTGFRDKGIHG-------------RR 882
            .:|:.|:|:......|.|..|:..  ||...:.:.:......|.....||             ..
Mouse   717 LAKQNISKALEHKEEAFNRGSMNPGVVSGGNTDQNLMTVPGSFNSYAYHGNTDQNFMTVPGSFNS 781

  Fly   883 YTTCGEDDQSH-AEKGILKKHGYGLVHGEQLKDKWGDDNQ 921
            |:..|..||:. ...|....:.|..|...:...:.|:|:|
Mouse   782 YSYHGNTDQNFMTVPGSFNSYSYQDVPYYRSIPEDGNDSQ 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	25/105 (24%)
		Reprolysin	270..473	CDD:279729	54/214 (25%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	54/212 (25%)
		Disintegrin	488..562	CDD:278623	31/75 (41%)
		ACR	566..713	CDD:214743	34/156 (22%)
Adam3	NP_033749.2	Pep_M12B_propep	27..144	CDD:307618	25/106 (24%)
		Reprolysin	187..382	CDD:330960	56/222 (25%)
		DISIN	404..480	CDD:214490	31/75 (41%)
		ACR	483..614	CDD:214743	34/157 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920