DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mmd and Adam22

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:XP_006503591.1 Gene:Adam22 / 11496 MGIID:1340046 Length:980 Species:Mus musculus


Alignment Length:1068 Identity:289/1068 - (27%)
Similarity:452/1068 - (42%) Gaps:238/1068 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 GEVERLLKEYRQN---QELVRRIGGHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSG 102
            |:..|.|:  ||:   ..|:.|:||.       .:.:|::   :.|            |...|.|
Mouse    37 GKENRFLE--RQSIIPLRLIYRLGGE-------DETQHNQ---LDT------------RVRGDPG 77

  Fly   103 FNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHG 167
               |....|..:.|..:.||...|.||:.||.:|||....::....||.:|:....  |||||.|
Mouse    78 ---GPQLTHVDKASFRVDAFGTSFVLDVLLNHELLSSGYVERQIEHGGKVVENKGG--EHCYYQG 137

  Fly   168 TVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYG--GDLSKHPHVIFEARTKANKGCANSGNL 230
            .::..|.:..|..||:|:.|:.:.||.|::|.|...  ...|.|.|.::::|       .....|
Mouse   138 QIRGNPVSFVALSTCHGLHGMFYDGNHTYLIEPEENEKSQESSHCHSVYKSR-------QFEFPL 195

  Fly   231 DSW------------------RLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAII 277
            |..                  ||.||.:.|.                |..|:|.|.|||||..|:
Mouse   196 DDLPSEFQRVNITPPQFILKPRLKRRKRQLL----------------RFPRNVEEETKYIELMIV 244

  Fly   278 VDKAMFDKRNGSTRAEVIHD---AIQVANIADLYFR-TLNTRVSVVYIETW-GKNQAVIDGSKDI 337
            .|..||.|.    |..|::.   |..|.|:||:.:: .|.||:.:|.:||| ..|:..|..:..|
Mouse   245 NDHLMFKKH----RLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAADNKFAISENPLI 305

  Fly   338 SKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVY-EPHLL 401
            :  :..|..| .|:..:.:.|...|.:|..|....:|.|....:|:....|   .||.: :..|:
Mouse   306 T--LREFMKY-RRDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRGG---GVNEFGKTDLM 364

  Fly   402 AGTMAHMIGHNIGMGHDDGR---EECFCRD-WHGCIMAQSIVGQENVQPYKFSECSKKDYIDALR 462
            |.|:|..:.||:|:..|..:   .||.|.| |.||||..:    ....|.||::|:.::|.|.|.
Mouse   365 AVTLAQSLAHNVGIISDKRKLASGECKCEDTWSGCIMGDT----GYYLPKKFTQCNVEEYHDFLN 425

  Fly   463 TGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECALD--QCCDGITCKLKSEAQCASGAC 525
            :|.|.||.|||:::.....|||..:|..|||||||..||||:  :||.  .|.|..::||:.|.|
Mouse   426 SGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECALEGAECCK--KCTLTQDSQCSDGLC 488

  Fly   526 CDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLS 590
            |.:|:.:|...:||::.|:||:.|.|.|...||..:|.|.:|..|    .|..|.||.|.|.|..
Mouse   489 CKKCKFQPLGTVCREAVNDCDIREICSGNSSQCAPNVHKMDGYSC----DGTQGICFGGRCKTRD 549

  Fly   591 LQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVND 655
            .||:.|||...:|:||.|||:.|.:|:..|:||:| .:.:.:|...:|.||.|.|.:....|...
Mouse   550 RQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKD-KDTWTQCNKRDVLCGYLLCTNIGNIPRLG 613

  Fly   656 GIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQT 720
            .:|...:.|::..:|:...|  :...|......:.|.|:||||||..::||...|:.: ...:.:
Mouse   614 ELDGEITSTLVVQQGRTLNC--SGAHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPV-ASFNFS 675

  Fly   721 KCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPY 785
            .|.::..|..||.:|||:|..:|.|:..|.|.||.:             ..|.|    :..:|..
Mouse   676 TCSSSKAGTVCSGNGVCSNELKCVCNRHWTGADCGT-------------HFPHN----DDAKTGI 723

  Fly   786 GTSDQNRISTLTMVIILTVIVKCVFISFATLAVC------YRRKTTTLKYDPPYSKKPIAKSYGG 844
            ..|......|   .||:.:|...:.:....|.:.      ||.:....:.|  |.|||       
Mouse   724 TLSGNGVAGT---NIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGD--YVKKP------- 776

  Fly   845 AATAPNHHSVEEVSLDGSSKLVYANQTGFRDKGIHGRRYTTCGEDDQSHAEKGILKKHGYGLVH- 908
                            |.....|::             :...|..:.:.:.    ||...||.| 
Mouse   777 ----------------GDGDSFYSD-------------FPPGGSTNSASSS----KKRSNGLSHS 808

  Fly   909 -GEQLKDKWGDDNQSDNLELITQDGTLASTS-----GG-----------AAASEVERTLKSLNGY 956
             .|::.|       :.::..|.::|...|.|     ||           ..::..||..::....
Mouse   809 WSERIPD-------TKHISDICENGRPRSNSWQGNMGGNKKKIRGKRFRPRSNSTEREPQAPEPG 866

  Fly   957 HEDILEALRNAATHRGTGTG--NTPVGSGSLSEEMLR----------KTLQDCNNSQLG--YSAE 1007
            |     :|......:|...|  ::| .:|||....|.          |.::|.|.:..|  :|::
Mouse   867 H-----SLAQTIPSQGISPGGSDSP-QTGSLDHRYLNPWFKRDYNVAKWVEDVNKNTEGPYFSSQ 925

  Fly  1008 ----QYKRNI----------GSKSSSRE 1021
                |..|.:          ||.:|||:
Mouse   926 DGPHQQDRTLSPAKSPSSSTGSIASSRK 953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 36/108 (33%)
Reprolysin 270..473 CDD:279729 68/212 (32%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 67/210 (32%)
Disintegrin 488..562 CDD:278623 33/75 (44%)
ACR 566..713 CDD:214743 49/146 (34%)
Adam22XP_006503591.1 Pep_M12B_propep 48..186 CDD:366707 45/164 (27%)
Reprolysin 237..436 CDD:366632 68/212 (32%)
Disintegrin 451..524 CDD:365943 33/74 (45%)
ACR 528..669 CDD:214743 49/147 (33%)
EGF_2 677..709 CDD:285248 12/31 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 72 1.000 Domainoid score I9277
eggNOG 1 0.900 - - E1_KOG3607
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 1 1.000 - - FOG0002073
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103986
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 1 1.000 - - X50
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.810

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