Protein Alignment mmd and Adam2

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_033748.2
• Gene: Adam2 / 11495
• MGIID: 1340894
• Length: 735
• Species: Mus musculus
• Alignment Length: 711
• Identity: 196/711 - (27%)
• Similarity: 304/711 - (42%)
• Gaps: 123/711 - (17%)

  Fly    77 EKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNI 141
            ||:.:   :|::|   ::.|....:|:..        :.:..:|.....:.||| :....|.||.
Mouse    27 EKLHV---QVTVP---EKIRSVTSNGYET--------QVTYNLKIEGKTYTLDL-MQKPFLPPNF 76

  Fly   142 QQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDL 206
            :...|...|.:....:.....||:.|.::.||.:.....||.|:.|.:..||.::.|.|....
Mouse    77 RVYSYDNAGIMRSLEQKFQNICYFQGYIEGYPNSMVIVSTCTGLRGFLQFGNVSYGIEPLESS-- 139

  Fly   207 SKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRD------- 264
            |...|||::  .:..||.|                           :|.|....:.||
Mouse   140 SGFEHVIYQ--VEPEKGGA---------------------------LLYAEKDIDLRDSQYKIRS 175

  Fly   265 ---VREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETW-G 325
               .|..:.|:|..|:|:|.||: ..|:..|.|.....|:..:|:..|...|..|.:..:|.| .
Mouse   176 IKPQRIVSHYLEIHIVVEKQMFE-HIGADTAIVTQKIFQLIGLANAIFAPFNLTVILSSLEFWMD 239

  Fly   326 KNQAVIDGSKDISKAISNFNDYTSRNL---------FQIERDTTQLLTGETFAGGEAGMAVPETV 381
            :|:.:..|  |.:|.:..|..:....|         ..:.|:||..: |.|:.|         .:
Mouse   240 ENKILTTG--DANKLLYRFLKWKQSYLVLRPHDMAFLLVYRNTTDYV-GATYQG---------KM 292

  Fly   382 CTPR-AVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHG---CIMAQSIVGQE 442
            |... |.|:::.........||..:..::..::|:.:|| ..:|.|    |   |:|........
Mouse   293 CDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGLAYDD-VNKCQC----GVPVCVMNPEAPHSS 352

  Fly   443 NVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN-----CGNKVVEEDEECDCGTFEECA 502
            .|:  .||.||.:|:...:.:....||.|:|   .|:.:     |||..|||||.||||. :.||
Mouse   353 GVR--AFSNCSMEDFSKFITSQSSHCLQNQP---RLQPSYKMAVCGNGEVEEDEICDCGK-KGCA 411

  Fly   503 --LDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKK 565
              ...||:..||||...::|:||.||:.|:|:.|..:||.:.:|||:.|||:|....| .|.|.:
Mouse   412 EMPPPCCNPDTCKLSDGSECSSGICCNSCKLKRKGEVCRLAQDECDVTEYCNGTSEVC-EDFFVQ 475

  Fly   566 NGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHY 630
            ||.||...|    ..|..|.|.:...||:.::|........:|:.:.|||..|:|.||..|. .|
Mouse   476 NGHPCDNRK----WICINGTCQSGEQQCQDLFGIDAGFGSSECFWELNSKSDISGSCGISAG-GY 535

  Fly   631 IKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKD 695
            .:|.|.:..||.:.||     ..::.|.:|.|.|:|........|.:.....|.|. .:...|:|
Mouse   536 KECPPNDRMCGKIICK-----YQSENILKLRSATVIYANISGHVCVSLEYPQGHNE-SQKMWVRD 594

  Fly   696 GTPCGDNLICLNQTCVS-LFPHVDQTKCPANSQGLE-CSEHGVCTNTNRCFCDMGWGGNDC 754
            ||.||.|.:|.||.||: .|...|   |     .|| |:.||||.|...|.||..:...||
Mouse   595 GTVCGSNKVCQNQKCVADTFLGYD---C-----NLEKCNHHGVCNNKKNCHCDPTYLPPDC 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	25/109 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	50/214 (23%)
		Disintegrin	488..561	CDD:459709	34/74 (46%)
		ACR	566..713	CDD:214743	47/147 (32%)
Adam2	NP_033748.2	Pep_M12B_propep	32..147	CDD:460254	29/128 (23%)
		Reprolysin	184..381	CDD:426256	51/216 (24%)
		Disintegrin	398..469	CDD:459709	33/71 (46%)
		ACR	475..610	CDD:214743	45/145 (31%)