Protein Alignment mmd and Adam19

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_033746.1
• Gene: Adam19 / 11492
• MGIID: 105377
• Length: 920
• Species: Mus musculus
• Alignment Length: 783
• Identity: 235/783 - (30%)
• Similarity: 346/783 - (44%)
• Gaps: 142/783 - (18%)

  Fly    92 GQRPRPHD--------DSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHV 148
            |..|..|:        .....||   ||..|..|.:.|...:..||||.|..|.:|...:..|..
Mouse    38 GSPPLQHELIIPQWRTSESPGRG---KHPLRAELRVMAEGRELILDLEKNEHLFAPAYTETCYTA 99

  Fly   149 GGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHI-GNETFVIHPFYGGDLSKHPHV 212
            .|..........:||:|||||:|...:|....||.|:.|:|.: .|.:::|.|....|   ..|.
Mouse   100 SGNPQTSTLKSEDHCFYHGTVRDVDESSVTLSTCRGIRGLIIVRSNLSYIIEPVPNSD---SQHR 161

  Fly   213 IFEAR----TKANKGCANSG-NLDSWRL--SRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATK 270
            |:.:.    ...|.|..:|| ....|.|  :.:||....               |.||:...:.|
Mouse   162 IYRSEHLTLPPGNCGFEHSGPTSKDWALQFTHQTKKQPR---------------RMKREDLHSMK 211

  Fly   271 YIETAIIVDKAMFDKRNGSTRAEVIHD-------AIQVANIADLYFRTLNTRVSVVYIETWGKNQ 328
            |:|..::.|.|.|.|..        ||       .:::||..|.::|:||.|:::|.:|.|....
Mouse   212 YVELYLVADYAEFQKNR--------HDQDATKRKLMEIANYVDKFYRSLNIRIALVGLEVWTHGD 268

  Fly   329 AVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTP-RAVGISVD 392
            . .:.|::....:.:|..:..:.|.|...|..||:||.:|.|...|:|....:|:. ::.|:|:|
Mouse   269 K-CEVSENPYSTLWSFLSWRRKLLAQKSHDNAQLITGRSFQGTTIGLAPLMAMCSVYQSGGVSMD 332

  Fly   393 VNVYEPHL-----LAGTMAHMIGHNIGMGHD----------DGREECFCRDWHGCIMAQSIVGQE 442
                  |.     :|.|:||.||||.||.||          ||          |||||   ....
Mouse   333 ------HSENAIGVASTVAHEIGHNFGMSHDSAHCCSASAADG----------GCIMA---AATG 378

  Fly   443 NVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL--RRNCGNKVVEEDEECDCGTFEECALDQ 505
            :..|..||.|::|:....|:||.|:||.|.|:...|  .|.|||..:|:.||||||..|||. :.
Mouse   379 HPFPKVFSWCNRKELDRYLQTGGGMCLSNMPDTRTLYGGRRCGNGYLEDGEECDCGEEEECK-NP 442

  Fly   506 CCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPC 570
            ||:...|.||..|:||.|:||.||:|......||:...:|||||:|.|:...||::.::.:|:||
Mouse   443 CCNASNCTLKEGAECAHGSCCHQCKLVAPGTQCREQVRQCDLPEFCTGKSPHCPTNYYQMDGTPC 507

  Fly   571 GLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEP 635
                .|...||:.|.|.|...||:.:||.|...|...|:|:.|:.|...|:||:..|..|.||.|
Mouse   508 ----EGGQAYCYNGMCLTYQEQCQQLWGPGARPALDLCFERVNAAGDTYGNCGKGLNGQYRKCSP 568

  Fly   636 ENVQCGTLQCKDGERQPVND---GIDQLYSRTIISIKGQEFECKAT------SGQVGSNSYPEHG 691
            .:.:||.:||:..:.:|:..   .||     |.|::.|:...|:.|      ..:.|.....:.|
Mouse   569 RDAKCGKIQCQSTQARPLESNAVSID-----TTITLNGRRIHCRGTHVYRGPEEEEGEGDMLDPG 628

  Fly   692 LVKDGTPCGDNLICLNQTC--VSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC 754
            ||..||.||.|.||....|  .|.|   :...|     |.:|:.||||.|...|.|..||....|
Mouse   629 LVMTGTKCGHNHICFEGQCRNTSFF---ETEGC-----GKKCNGHGVCNNNKNCHCFPGWSPPFC 685

  Fly   755 SSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVC 819
            :               ||.:...::....|..:.........:.:.:|.|:|        .|..|
Mouse   686 N---------------TPGDGGSVDSGPLPPKSVGPVIAGVFSALFVLAVLV--------LLCHC 727

  Fly   820 YRR 822
            ||:
Mouse   728 YRQ 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	35/110 (32%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	67/223 (30%)
		Disintegrin	488..561	CDD:459709	35/72 (49%)
		ACR	566..713	CDD:214743	51/157 (32%)
Adam19	NP_033746.1	Pep_M12B_propep	45..163	CDD:460254	35/123 (28%)
		Cysteine switch. /evidence=ECO:0000250	131..138		3/6 (50%)
		Reprolysin	211..409	CDD:426256	68/225 (30%)
		DISIN	440..500	CDD:214490	25/60 (42%)
		ACR	502..650	CDD:214743	51/156 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	755..920
		SH3-binding. /evidence=ECO:0000255	835..846