DRSC/TRiP Functional Genomics Resources

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Protein Alignment mmd and Adam15

DIOPT Version :10

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_001396408.1 Gene:Adam15 / 11490 MGIID:1333882 Length:878 Species:Mus musculus


Alignment Length:677 Identity:207/677 - (30%)
Similarity:329/677 - (48%) Gaps:81/677 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 RLDLELNSQLLSPNIQQKHYHVGG------YLVDGNR-----HDIEHCYYHGTVKDYPGASAAFH 180
            |:.|||:|:.....:.|....:.|      |..||.|     :.:|:|.|.|.|:.:|.:..:..
Mouse    71 RISLELDSESHVLELLQNRDLIPGRPTLVWYQPDGTRMVSEGYSLENCCYRGRVQGHPSSWVSLC 135

  Fly   181 TCNGVSGVIHIGNE---TFVIHPFYGGDLSK------HPHVIFEARTKANKGCANSGNLDSWRLS 236
            .|:|:.|:|.:..|   |..:.|   |||.:      ..|::.      ...||     .||..|
Mouse   136 ACSGIRGLIVLSPERGYTLELGP---GDLQRPVISRIQDHLLL------GHTCA-----PSWHAS 186

  Fly   237 RRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQV 301
            ..|:   ||...::|   |....|.||||...||.:|..|:.|.:  :.|......::::..::.
Mouse   187 VPTR---AGPDLLLE---QHHAHRLKRDVVTETKIVELVIVADNS--EVRKYPDFQQLLNRTLEA 243

  Fly   302 ANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF-QIERDTTQLLTG 365
            |.:.|.:|:.||.||::|.:|.|.::. :|:.|.:.:..:.||..:...:|. ::..|:.||:|.
Mouse   244 ALLLDTFFQPLNVRVALVGLEAWTQHN-LIEMSSNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTV 307

  Fly   366 ETFAGGEAGMAVPETVCTPR-AVGISVDVNVYEPHLL--AGTMAHMIGHNIGMGHDDGREECFC- 426
            .:|:|...|||:..::|:|. :.|:::|   :...:|  |.::||.:||::|:.||.....|.| 
Mouse   308 TSFSGPMVGMAIQNSICSPDFSGGVNMD---HSTSILGVASSIAHELGHSLGLDHDSPGHSCPCP 369

  Fly   427 --RDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNK-PNEIELRRNCGNKVVE 488
              .....|||..|   .:.:....||.||::....||..|.|.||..: |:...:...|||..|:
Mouse   370 GPAPAKSCIMEAS---TDFLPGLNFSNCSRQALEKALLEGMGSCLFERQPSLAPMSSLCGNMFVD 431

  Fly   489 EDEECDCGTFEECALDQCCDGITCKLKSEAQCAS-GACCDQCRLRPKDYICRDSNNECDLPEYCD 552
            ..|:||||..:||. |.|||..||:|:..||||| |.||..|:|.|..::||...::|||||:|.
Mouse   432 PGEQCDCGFPDECT-DPCCDHFTCQLRPGAQCASDGPCCQNCKLHPAGWLCRPPTDDCDLPEFCP 495

  Fly   553 GEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGS 617
            |:..|||||:...:|.||...:    ..|..|.|.:.:.||:::||.|...|...|.:..|::|:
Mouse   496 GDSSQCPSDIRLGDGEPCASGE----AVCMHGRCASYARQCQSLWGPGAQPAAPLCLQTANTRGN 556

  Fly   618 INGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQV 682
            ..|.|||.....|:.|.|.:|.||.|||:.|..||:...:....|. ::...|.:..|......:
Mouse   557 AFGSCGRSPGGSYMPCAPRDVMCGQLQCQWGRSQPLLGSVQDRLSE-VLEANGTQLNCSWVDLDL 620

  Fly   683 GSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLE-----CSEHGVCTNTNR 742
            | |...:..|...||.||..|:|:...|.           |.:..|.:     |..||||.::..
Mouse   621 G-NDVAQPLLALPGTACGPGLVCIGHRCQ-----------PVDLLGAQECRRKCHGHGVCDSSGH 673

  Fly   743 CFCDMGWGGNDCSSVVLLTTALPTEAL 769
            |.|:.||...||.:.:..|::|.|..|
Mouse   674 CRCEEGWAPPDCMTQLKATSSLTTGLL 700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 104..214 CDD:460254 28/106 (26%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 58/207 (28%)
Disintegrin 488..561 CDD:459709 37/73 (51%)
ACR 566..713 CDD:214743 44/146 (30%)
Adam15NP_001396408.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..45
Pep_M12B_propep <74..147 CDD:460254 20/72 (28%)
Cysteine switch. /evidence=ECO:0000250 177..184 3/11 (27%)
ZnMc_adamalysin_II_like 214..412 CDD:239797 57/206 (28%)
DISIN 431..504 CDD:214490 37/73 (51%)
ACR 509..650 CDD:214743 44/157 (28%)
SH3-binding. /evidence=ECO:0000255 830..836
SH3-binding. /evidence=ECO:0000255 865..871
Blue background indicates that the domain is not in the aligned region.

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