DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam15

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001032811.2	Gene:	Adam15 / 11490	MGIID:	1333882	Length:	864	Species:	Mus musculus

Alignment Length:	749	Identity:	217/749 - (28%)
Similarity:	354/749 - (47%)	Gaps:	113/749 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 RLDLELNSQLLSPNIQQKHYHVGG------YLVDGNR-----HDIEHCYYHGTVKDYPGASAAFH 180
            |:.|||:|:.....:.|....:.|      |..||.|     :.:|:|.|.|.|:.:|.:..:..
Mouse    71 RISLELDSESHVLELLQNRDLIPGRPTLVWYQPDGTRMVSEGYSLENCCYRGRVQGHPSSWVSLC 135

  Fly   181 TCNGVSGVIHIGNE---TFVIHPFYGGDLSK------HPHVIFEARTKANKGCANSGNLDSWRLS 236
            .|:|:.|:|.:..|   |..:.|   |||.:      ..|::.      ...||     .||..|
Mouse   136 ACSGIRGLIVLSPERGYTLELGP---GDLQRPVISRIQDHLLL------GHTCA-----PSWHAS 186

  Fly   237 RRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQV 301
            ..|:   ||...::|   |....|.||||...||.:|..|:.|.:  :.|......::::..::.
Mouse   187 VPTR---AGPDLLLE---QHHAHRLKRDVVTETKIVELVIVADNS--EVRKYPDFQQLLNRTLEA 243

  Fly   302 ANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF-QIERDTTQLLTG 365
            |.:.|.:|:.||.||::|.:|.|.::. :|:.|.:.:..:.||..:...:|. ::..|:.||:|.
Mouse   244 ALLLDTFFQPLNVRVALVGLEAWTQHN-LIEMSSNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTV 307

  Fly   366 ETFAGGEAGMAVPETVCTPR-AVGISVDVNVYEPHLL--AGTMAHMIGHNIGMGHDDGREECFC- 426
            .:|:|...|||:..::|:|. :.|:::|   :...:|  |.::||.:||::|:.||.....|.|
Mouse   308 TSFSGPMVGMAIQNSICSPDFSGGVNMD---HSTSILGVASSIAHELGHSLGLDHDSPGHSCPCP 369

  Fly   427 --RDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNK-PNEIELRRNCGNKVVE 488
              .....|||..|   .:.:....||.||::....||..|.|.||..: |:...:...|||..|:
Mouse   370 GPAPAKSCIMEAS---TDFLPGLNFSNCSRQALEKALLEGMGSCLFERQPSLAPMSSLCGNMFVD 431

  Fly   489 EDEECDCGTFEECALDQCCDGITCKLKSEAQCAS-GACCDQCRLRPKDYICRDSNNECDLPEYCD 552
            ..|:||||..:||. |.|||..||:|:..||||| |.||..|:|.|..::||...::|||||:|.
Mouse   432 PGEQCDCGFPDECT-DPCCDHFTCQLRPGAQCASDGPCCQNCKLHPAGWLCRPPTDDCDLPEFCP 495

  Fly   553 GEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGS 617
            |:..|||||:...:|.||...:    ..|..|.|.:.:.||:::||.|...|...|.:..|::|:
Mouse   496 GDSSQCPSDIRLGDGEPCASGE----AVCMHGRCASYARQCQSLWGPGAQPAAPLCLQTANTRGN 556

  Fly   618 INGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQV 682
            ..|.|||.....|:.|.|.:|.||.|||:.|..||:...:....|. ::...|.:..|......:
Mouse   557 AFGSCGRSPGGSYMPCAPRDVMCGQLQCQWGRSQPLLGSVQDRLSE-VLEANGTQLNCSWVDLDL 620

  Fly   683 GSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLE-----CSEHGVCTNTNR 742
            | |...:..|...||.||..|:|:...|.           |.:..|.:     |..||||.::..
Mouse   621 G-NDVAQPLLALPGTACGPGLVCIGHRCQ-----------PVDLLGAQECRRKCHGHGVCDSSGH 673

  Fly   743 CFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVK 807
            |.|:.||...||.:.:..|::|.|..|                          |:::::|.:::
Mouse   674 CRCEEGWAPPDCMTQLKATSSLTTGLL--------------------------LSLLLLLVLVL- 711

  Fly   808 CVFISFATLAVCYRR----KTTTLKYDPPYSKKP 837
             :..|:...|..::|    |.::.:|..|.|..|
Mouse   712 -LGASYWHRARLHQRLCQLKGSSCQYRAPQSCPP 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	28/105 (27%)
		Reprolysin	270..473	CDD:279729	58/210 (28%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	58/207 (28%)
		Disintegrin	488..562	CDD:278623	38/74 (51%)
		ACR	566..713	CDD:214743	44/146 (30%)
Adam15	NP_001032811.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..45
		Pep_M12B_propep	67..155	CDD:279848	23/83 (28%)
		Cysteine switch. /evidence=ECO:0000250	177..184		3/11 (27%)
		Reprolysin	214..414	CDD:279729	58/208 (28%)
		ZnMc_adamalysin_II_like	214..412	CDD:239797	57/206 (28%)
		DISIN	431..504	CDD:214490	37/73 (51%)
		ACR	509..650	CDD:214743	44/157 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..864		4/9 (44%)
		SH3-binding. /evidence=ECO:0000255	816..822
		SH3-binding. /evidence=ECO:0000255	851..857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7811
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.950