DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mmd and Adam12

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_031426.2 Gene:Adam12 / 11489 MGIID:105378 Length:903 Species:Mus musculus


Alignment Length:794 Identity:253/794 - (31%)
Similarity:363/794 - (45%) Gaps:131/794 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
            |.||.|..|::....:.||...|..|...|:..:||||||.|:....:..:..||:|:.|:|...
Mouse    82 LSLERNEGLIANGFTETHYLQDGTDVSLTRNHTDHCYYHGHVQGDAASVVSLSTCSGLRGLIMFE 146

  Fly   193 NETFVIHPFYGGDLSKHPHVIFEARTKANKGCA---NSGNLDSWRLSRRTKHLSAGVAGVVEEIL 254
            |:|:.:.|. ......:..|..|:.|.....|.   |..||....:|..|..:.|          
Mouse   147 NKTYSLEPM-KNTTDSYKLVPAESMTNIQGLCGSQHNKSNLTMEDVSPGTSQMRA---------- 200

  Fly   255 QAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVV 319
                .|:||:..:.|||:|..|:.|...| :|.|....:|....|::||..|.::|.||.|:.:|
Mouse   201 ----RRHKRETLKMTKYVELVIVADNREF-QRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLV 260

  Fly   320 YIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF----------QIERDTTQLLTGETFAGGEAG 374
            .:|.|          .||.|...:.:.:||.:.|          :...|..||::|..|.|...|
Mouse   261 GVEVW----------NDIDKCSISQDPFTSLHEFLDWRKIKLLPRKSHDNAQLISGVYFQGTTIG 315

  Fly   375 MAVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCR---DWHGCIMAQ 436
            ||...::||....|..|..:...|...|.|:||.:|||.||.||.....|.||   :..||||..
Mouse   316 MAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNP 380

  Fly   437 SIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELR---RNCGNKVVEEDEECDCGTF 498
            | .|..  .|..||.||:||...:|..|.|:||.|.| |::..   |.|||..|||.||||||..
Mouse   381 S-TGFP--FPMVFSSCSRKDLEASLEKGMGMCLFNLP-EVKQAFGGRKCGNGYVEEGEECDCGEP 441

  Fly   499 EECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVF 563
            |||. ::||:..||.||.:|.||.|.||:.|:|:|....||.|:|.|||||:|.|....||::|:
Mouse   442 EECT-NRCCNATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDLPEFCTGTAPHCPANVY 505

  Fly   564 KKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANE 628
            ..:|.||    .|:.|||:.|.|.|...||..:||.|...|...|:|:.||.|...|:||:|:..
Mouse   506 LHDGHPC----QGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKS 566

  Fly   629 HYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRT-IISIKGQEFECKATSGQVGSNSYPEHGL 692
            .:.|||..:.:||.:||:.|..:|| .|.:.:...| |...:|....|:.|...:| :..|:.||
Mouse   567 AFAKCELRDAKCGKIQCQGGASRPV-IGTNAVSIETNIPQQEGGRILCRGTHVYLG-DDMPDPGL 629

  Fly   693 VKDGTPCGDNLICLNQTC--VSLF-PHVDQTKCPANSQGLECSEHGVCTNTNRC---------FC 745
            |..||.|.:..||||:.|  :|:| .|    ||     .::|...|||.|...|         ||
Mouse   630 VLAGTKCAEGKICLNRRCQNISVFGVH----KC-----AMQCHGRGVCNNRKNCHCEAHWAPPFC 685

  Fly   746 D-MGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVK-- 807
            | .|:||:..|.                           |...:|...::...:|.||.::..  
Mouse   686 DKFGFGGSTDSG---------------------------PIRQADNQGLTVGILVSILCLLAAGF 723

  Fly   808 CVFISFATL-AVCYRRKTTTLK----YDPPYSKKPIAKSYGGAATAP----------------NH 851
            .|::...|| .:.:..|.||::    ..|  |:.|.....|.|...|                :.
Mouse   724 VVYLKRKTLMRLLFTHKKTTMEKLRCVHP--SRTPSGPHLGQAHHTPGKGLLMNRAPHFNTPKDR 786

  Fly   852 HSVEEVSLDGSSKL 865
            ||::..::|.|..|
Mouse   787 HSLKCQNMDISRPL 800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 25/84 (30%)
Reprolysin 270..473 CDD:279729 73/215 (34%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 72/213 (34%)
Disintegrin 488..562 CDD:278623 39/73 (53%)
ACR 566..713 CDD:214743 54/149 (36%)
Adam12NP_031426.2 Pep_M12B_propep 64..161 CDD:279848 25/79 (32%)
Cysteine switch. /evidence=ECO:0000250 175..182 1/6 (17%)
Reprolysin 212..414 CDD:279729 73/215 (34%)
ZnMc_adamalysin_II_like 212..412 CDD:239797 72/213 (34%)
DISIN 437..505 CDD:214490 34/68 (50%)
ACR 508..650 CDD:214743 54/147 (37%)
CAC1F_C <751..>848 CDD:293490 11/52 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..790 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..903
SH3-binding, class II 824..830
SH3-binding, class I 830..837
SH3-binding, class II 846..852
NSP2-B_epitope <848..>896 CDD:258894
SH3-binding, class I 852..858
SH3-binding, class I 881..887
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 89 1.000 Domainoid score I7811
eggNOG 1 0.900 - - E1_KOG3607
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 1 1.000 - - X50
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.950

Return to query results.
Submit another query.