DRSC/TRiP Functional Genomics Resources

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Protein Alignment mmd and Adam12

DIOPT Version :10

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_031426.2 Gene:Adam12 / 11489 MGIID:105378 Length:903 Species:Mus musculus


Alignment Length:794 Identity:253/794 - (31%)
Similarity:363/794 - (45%) Gaps:131/794 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
            |.||.|..|::....:.||...|..|...|:..:||||||.|:....:..:..||:|:.|:|...
Mouse    82 LSLERNEGLIANGFTETHYLQDGTDVSLTRNHTDHCYYHGHVQGDAASVVSLSTCSGLRGLIMFE 146

  Fly   193 NETFVIHPFYGGDLSKHPHVIFEARTKANKGCA---NSGNLDSWRLSRRTKHLSAGVAGVVEEIL 254
            |:|:.:.|. ......:..|..|:.|.....|.   |..||....:|..|..:.|          
Mouse   147 NKTYSLEPM-KNTTDSYKLVPAESMTNIQGLCGSQHNKSNLTMEDVSPGTSQMRA---------- 200

  Fly   255 QAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVV 319
                .|:||:..:.|||:|..|:.|...| :|.|....:|....|::||..|.::|.||.|:.:|
Mouse   201 ----RRHKRETLKMTKYVELVIVADNREF-QRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLV 260

  Fly   320 YIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF----------QIERDTTQLLTGETFAGGEAG 374
            .:|.|          .||.|...:.:.:||.:.|          :...|..||::|..|.|...|
Mouse   261 GVEVW----------NDIDKCSISQDPFTSLHEFLDWRKIKLLPRKSHDNAQLISGVYFQGTTIG 315

  Fly   375 MAVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCR---DWHGCIMAQ 436
            ||...::||....|..|..:...|...|.|:||.:|||.||.||.....|.||   :..||||..
Mouse   316 MAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNP 380

  Fly   437 SIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELR---RNCGNKVVEEDEECDCGTF 498
            | .|..  .|..||.||:||...:|..|.|:||.|.| |::..   |.|||..|||.||||||..
Mouse   381 S-TGFP--FPMVFSSCSRKDLEASLEKGMGMCLFNLP-EVKQAFGGRKCGNGYVEEGEECDCGEP 441

  Fly   499 EECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVF 563
            |||. ::||:..||.||.:|.||.|.||:.|:|:|....||.|:|.|||||:|.|....||::|:
Mouse   442 EECT-NRCCNATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDLPEFCTGTAPHCPANVY 505

  Fly   564 KKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANE 628
            ..:|.||    .|:.|||:.|.|.|...||..:||.|...|...|:|:.||.|...|:||:|:..
Mouse   506 LHDGHPC----QGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKS 566

  Fly   629 HYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRT-IISIKGQEFECKATSGQVGSNSYPEHGL 692
            .:.|||..:.:||.:||:.|..:|| .|.:.:...| |...:|....|:.|...:| :..|:.||
Mouse   567 AFAKCELRDAKCGKIQCQGGASRPV-IGTNAVSIETNIPQQEGGRILCRGTHVYLG-DDMPDPGL 629

  Fly   693 VKDGTPCGDNLICLNQTC--VSLF-PHVDQTKCPANSQGLECSEHGVCTNTNRC---------FC 745
            |..||.|.:..||||:.|  :|:| .|    ||     .::|...|||.|...|         ||
Mouse   630 VLAGTKCAEGKICLNRRCQNISVFGVH----KC-----AMQCHGRGVCNNRKNCHCEAHWAPPFC 685

  Fly   746 D-MGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVK-- 807
            | .|:||:..|.                           |...:|...::...:|.||.::..  
Mouse   686 DKFGFGGSTDSG---------------------------PIRQADNQGLTVGILVSILCLLAAGF 723

  Fly   808 CVFISFATL-AVCYRRKTTTLK----YDPPYSKKPIAKSYGGAATAP----------------NH 851
            .|::...|| .:.:..|.||::    ..|  |:.|.....|.|...|                :.
Mouse   724 VVYLKRKTLMRLLFTHKKTTMEKLRCVHP--SRTPSGPHLGQAHHTPGKGLLMNRAPHFNTPKDR 786

  Fly   852 HSVEEVSLDGSSKL 865
            ||::..::|.|..|
Mouse   787 HSLKCQNMDISRPL 800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 104..214 CDD:460254 26/85 (31%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 72/213 (34%)
Disintegrin 488..561 CDD:459709 39/72 (54%)
ACR 566..713 CDD:214743 54/149 (36%)
Adam12NP_031426.2 Pep_M12B_propep 64..161 CDD:460254 25/79 (32%)
Cysteine switch. /evidence=ECO:0000250 175..182 1/6 (17%)
Reprolysin 212..414 CDD:426256 73/215 (34%)
DISIN 437..505 CDD:214490 34/68 (50%)
ACR 508..650 CDD:214743 54/147 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..790 7/36 (19%)
PHA03247 <796..897 CDD:223021 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..903
SH3-binding, class II 824..830
SH3-binding, class I 830..837
SH3-binding, class II 846..852
SH3-binding, class I 852..858
SH3-binding, class I 881..887
Blue background indicates that the domain is not in the aligned region.

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