DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam11

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_006532077.1	Gene:	Adam11 / 11488	MGIID:	1098667	Length:	854	Species:	Mus musculus

Alignment Length:	890	Identity:	278/890 - (31%)
Similarity:	394/890 - (44%)	Gaps:	161/890 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDS 101
            |||.|      .|..:...|||:..|                     .||..|:...|.|.....
Mouse    44 ESPEG------SEVTEPSRLVRQSSG---------------------GEVRKPQLDTRVRQDPPR 81

  Fly   102 GFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDI---EHC 163
            |     |..|..:.|.:|.||:..|.||||||..|||....::|:...|    ..:|..   :||
Mouse    82 G-----TPVHLAQVSFVIPAFDSNFTLDLELNHHLLSSQYVERHFSREG----TRQHSTGAGDHC 137

  Fly   164 YYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPF-----YGGDLSKHPHVIFEART---KA 220
            ||||.::..|.:.||..||.|:.||...||.|:::.|.     :|......||:|:  ||   .|
Mouse   138 YYHGKLRGNPQSFAALSTCQGLHGVFSDGNLTYIVEPKEIAGPWGPPQGPLPHLIY--RTPLLPA 200

  Fly   221 NKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGV---------------GRNKRDVREA-- 268
            ..||...|        :|.:...||..|....:...|.               .|.||.||..
Mouse   201 PLGCREPG--------KRGEGGGAGRPGPSYLLFPTGCLFAVPAQSALPNWPKLRRKRQVRRGHP 257

  Fly   269 -----TKYIETAIIVDKAMFDKRNGSTRAEVI---HDAIQVANIAD-LYFRTLNTRVSVVYIETW 324
                 |||:|..:|.|..:|::    .|..|:   :.|..|.|:|| :|...||||:.:|.:|||
Mouse   258 TVHSETKYVELIVINDHQLFEQ----MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETW 318

  Fly   325 GKNQAVIDGSK-----DISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTP 384
            .      ||.|     |:.:.::....|....|.: ..|.|.|.:|.||....:|.|....:|:.
Mouse   319 A------DGDKIQVQDDLLETLARLMVYRREGLPE-PSDATHLFSGRTFQSTSSGAAYVGGICSL 376

  Fly   385 RAVGISVDVNVY-EPHLLAGTMAHMIGHNIGM---GHDDGREECFCRD-WHGCIMAQSIVGQENV 444
            ...|   .||.| ....:|.|:|..:|.|:||   .|.....:|.|.| |.||||..:    ...
Mouse   377 SRGG---GVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDT----GFY 434

  Fly   445 QPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEEC--ALDQCC 507
            .|.|||.||..:|...|:.|.|.||.|||.::.....|||..||..||||||:.:||  |...||
Mouse   435 LPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCC 499

  Fly   508 DGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGL 572
            .  .|.|..:|.|:.|.||.:|:..|:...||::.||||:.|.|.|:..|||.::.|.:|..|..
Mouse   500 K--KCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDH 562

  Fly   573 SKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPEN 637
            .:    |.|:.|.|.|...||:|:||:  :||||.|||:.|.:|:..|:|||..: .:::|..::
Mouse   563 EQ----GRCYGGRCKTRDRQCQALWGH--AAADRFCYEKLNVEGTERGNCGRKGS-GWVQCSKQD 620

  Fly   638 VQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDN 702
            |.||.|.|.:....|....:....|......:|:|.:|:....|:...|  :...|:|||.||.|
Mouse   621 VLCGFLLCVNISGAPRLGDLGGDISSVTFYHQGKELDCRGGHVQLADGS--DLSYVEDGTACGPN 683

  Fly   703 LICLNQTCV--SLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALP 765
            ::||:..|:  |.|   :.:.||.:.:...||.||||:|..:|.|...|.|.|||    :...||
Mouse   684 MLCLDHRCLPASAF---NFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCS----IHNPLP 741

  Fly   766 TEALPTPENTIKMEKKETPYGTSDQNR--------ISTLTMVIILTVIVKCVFISFATL------ 816
            |.. ||.| |.:.::.....||:..:|        |....:|.|.:|.:..|......:
Mouse   742 TSP-PTGE-TERYKETSVVEGTTRPSRGQCDAGHVIPPAVLVSISSVPLHSVDRELGPIRFPKPC 804

  Fly   817 ------AVCYRR----KTTTLKYDPPYSKKPIAKSYG--GAATAP 849
                  .:|..|    .|..|...||.|....|.|:|  ||.|.|
Mouse   805 REPGKRVLCLLRPFLLPTRLLGPGPPSSVLSAAGSHGRVGAGTVP 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	40/114 (35%)
		Reprolysin	270..473	CDD:279729	70/216 (32%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	69/214 (32%)
		Disintegrin	488..562	CDD:278623	33/75 (44%)
		ACR	566..713	CDD:214743	48/148 (32%)
Adam11	XP_006532077.1	Pep_M12B_propep	50..193	CDD:366707	51/172 (30%)
		Reprolysin	264..463	CDD:366632	70/216 (32%)
		Disintegrin	478..551	CDD:365943	33/74 (45%)
		ACR	555..693	CDD:214743	48/146 (33%)
		EGF_2	702..734	CDD:285248	13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9277
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7614
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0002073
OrthoInspector	1	1.000	-	-		oto94167
orthoMCL	1	0.900	-	-		OOG6_103986
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.810