DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and ADAM29

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001124175.1	Gene:	ADAM29 / 11086	HGNCID:	207	Length:	820	Species:	Homo sapiens

Alignment Length:	783	Identity:	210/783 - (26%)
Similarity:	350/783 - (44%)	Gaps:	143/783 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYY 165
            :|..||.|...:  .|.::.....|..:.:::...|.|.::....|...|.:::.......:|||
Human    40 TGTTRGMTPPGW--LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYY 102

  Fly   166 HGTVKDYPGASAAFHTC-NGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGN 229
            ||.|:..|.:..:..|| .|..|::.|.:..:.|.|.  ...:...|::::
Human   103 HGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPL--AFSTTFEHLVYK-------------- 151

  Fly   230 LDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRD--VREATKY---------IETAIIVDKAMF 283
            :||     ..|..|...:|.::..:...:...:.|  .::.:.|         :|..:::|..::
Human   152 MDS-----EEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLY 211

  Fly   284 DK--RNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETW-GKNQAVIDGSKDISKAISNFN 345
            .:  ||.|   :::.|...:.||.|.....:..:|.:..:|.| .||..|:|   |:.|::..:.
Human   212 IRYERNDS---KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD---DVRKSVHLYC 270

  Fly   346 DYTSRNLF-QIERDTTQLLTGETFA-GGEAGMAVPETVCTP-RAVGISVDVNVYEPHLLAGT--- 404
            .:.|.|:. :::.||:.|.|  |.. .|.:|:.....:||| |:..|...:|     ...||
Human   271 KWKSENITPRMQHDTSHLFT--TLGLRGLSGIGAFRGMCTPHRSCAIVTFMN-----KTLGTFSI 328

  Fly   405 -MAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYID--------A 460
             :||.:|||:||.||    |..||    |...:.|:.:.|....|||.||..|:.:        .
Human   329 AVAHHLGHNLGMNHD----EDTCR----CSQPRCIMHEGNPPITKFSNCSYGDFWEYTVERTKCL 385

  Fly   461 LRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGAC 525
            |.|.|...:.|.       :.|||.||||.||||||..:.||.|.||.. .|.|...:.||.|.|
Human   386 LETVHTKDIFNV-------KRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLC 442

  Fly   526 CDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLS 590
            |..|:..|...:||...|||||||:|:|...:||.|.:.::|.||     ...|||::..|...:
Human   443 CKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPC-----KERGYCYEKSCHDRN 502

  Fly   591 LQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQP-VN 654
            .||..|:|.|.:.|...||::.|:.|...|||| ..|..||||...:||||.:||::....| ::
Human   503 EQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTEIPNMS 566

  Fly   655 DGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQ 719
            |      ..|:...:..:..|.:|...:|... |:.|.|||||.||.:.||:::.||    |:
Human   567 D------HTTVHWARFNDIMCWSTDYHLGMKG-PDIGEVKDGTECGIDHICIHRHCV----HI-- 618

  Fly   720 TKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC------SSVVLLTTALPTEALPTPENTIKM 778
            |...:|.....|::.|:|.|.:.|.|:..|...:|      .||         ::.|.|:   :.
Human   619 TILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV---------DSGPPPK---RK 671

  Fly   779 EKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRK---------TTTLKYDPPYS 834
            :||:..|        ..:.::|:|.:::.|::      .:|.:.|         |.:.|.:....
Human   672 KKKKFCY--------LCILLLIVLFILLCCLY------RLCKKSKPIKKQQDVQTPSAKEEEKIQ 722

  Fly   835 KKP 837
            ::|
Human   723 RRP 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	23/107 (21%)
		Reprolysin	270..473	CDD:279729	61/229 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	60/227 (26%)
		Disintegrin	488..562	CDD:278623	35/73 (48%)
		ACR	566..713	CDD:214743	51/147 (35%)
ADAM29	NP_001124175.1	Pep_M12B_propep	32..150	CDD:307618	25/113 (22%)
		ZnMc_adamalysin_II_like	198..386	CDD:239797	56/208 (27%)
		Disintegrin	406..478	CDD:306668	35/72 (49%)
		ACR	483..618	CDD:214743	51/151 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..820		3/20 (15%)
		PAT1	<725..>819	CDD:330585	1/1 (100%)
		9 X 9 AA approximate repeats	739..819
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146062
Domainoid	1	1.000	104	1.000	Domainoid score	I6691
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850