DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam33

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_291093.2	Gene:	Adam33 / 110751	MGIID:	1341813	Length:	797	Species:	Mus musculus

Alignment Length:	703	Identity:	223/703 - (31%)
Similarity:	340/703 - (48%)	Gaps:	108/703 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 EVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVG 149
            :|:|.:|..:|    ||             ..:.::|......|:||...:||:|...:.||...
Mouse    54 KVTLEEPILKP----DS-------------VLVALEAEGQDLLLELEKKHKLLAPGYTETHYRPD 101

  Fly   150 GYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNE-TFVIHPFYGGDLSKHP-HV 212
            |:.|..:.:..:||.|||.|:.:..:.....||:|:||:|.:.:: ::.:.|...||....| |.
Mouse   102 GHPVVLSPNHTDHCQYHGRVRGFRESWVVLSTCSGMSGLIVLSSKVSYYLQPRTPGDTKDFPTHE 166

  Fly   213 IFEARTKANKGCANSGNLDSWRLSRRTKH--LSAGVAGVVEEILQAGVGRNKRDVREATKYIETA 275
            ||...           .|.:||..:|.|:  ..||:|. :..:.|:   |.:|:.|.:.:|:|..
Mouse   167 IFRME-----------QLFTWRGVQRDKNSQYKAGMAS-LPHVPQS---RVRREARRSPRYLELY 216

  Fly   276 IIVDKAMF---DKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDI 337
            |:.|..:|   .:....||..:    ::|||..|...|||:.::.:..:|.|.:        :|:
Mouse   217 IVADHTLFLLQHQNLNHTRQRL----LEVANCVDQILRTLDIQLVLTGLEVWTE--------QDL 269

  Fly   338 SKAISNFNDYTSRNLFQIER--------DTTQLLTGETFAGGEAGMAVPETVCTPRAV-GISVDV 393
            |:...:.|: |.....|..|        |:||||||.||.|...|:|..|.:|...:. |:|.|.
Mouse   270 SRITQDANE-TLWAFLQWRRGVWARRPHDSTQLLTGRTFQGTTVGLAPVEGICRAESSGGVSTDH 333

  Fly   394 NVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCR---DWHGCIMAQSIVGQENVQPYKFSECSKK 455
            :.. |...|.||||.|||::|:.||.  |.|..:   :..||:| ::..|  :..|..||.||::
Mouse   334 SEL-PIGTAATMAHEIGHSLGLHHDP--EGCCVQADAEQGGCVM-EAATG--HPFPRVFSACSRR 392

  Fly   456 DYIDALRTGHGLCLLN--KPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEA 518
            ......|.|.|.||.|  .|..:.|...|||..:|..||||||:.::|. |.||....|.|::.|
Mouse   393 QLRTFFRKGGGPCLSNTSAPGLLVLPSRCGNGFLEAGEECDCGSGQKCP-DPCCFAHNCSLRAGA 456

  Fly   519 QCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQ 583
            |||.|.||.:|.|:.....||.:..:|||||:|.|....||:||:..:||||...:    |||..
Mouse   457 QCAHGDCCARCLLKSAGTPCRPAATDCDLPEFCTGTSPYCPADVYLLDGSPCAEGR----GYCLD 517

  Fly   584 GYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDG 648
            |:||||..||:.:||.|...|...|::|.||.|:..|:||:|....::.|...:..||.|.|:.|
Mouse   518 GWCPTLEQQCQQLWGPGSKPAPEPCFQQMNSMGNSQGNCGQDHKGSFLPCAQRDALCGKLLCQGG 582

  Fly   649 ERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEH-------GLVKDGTPCGDNLICL 706
            |..|:...|..:.| ||: ::|:|..|:      |:...|:.       |||:.||.||..::|.
Mouse   583 EPNPLVPHIVTMDS-TIL-LEGREVVCR------GAFVLPDSHLDQLDLGLVEPGTGCGPRMVCQ 639

  Fly   707 NQTCVSLFPHVDQTKCPANSQGLE-----CSEHGVCTNTNRCFCDMGWGGNDC 754
            ::.|.:           |.||.||     |...|||.:...|.|..||....|
Mouse   640 DRHCQN-----------ATSQELERCLTACHNGGVCNSNRNCHCAAGWAPPFC 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	28/108 (26%)
		Reprolysin	270..473	CDD:279729	68/219 (31%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	67/215 (31%)
		Disintegrin	488..562	CDD:278623	33/73 (45%)
		ACR	566..713	CDD:214743	53/153 (35%)
Adam33	NP_291093.2	Pep_M12B_propep	57..165	CDD:279848	32/124 (26%)
		Cysteine switch. /evidence=ECO:0000250	132..139		3/6 (50%)
		Reprolysin	211..408	CDD:279729	67/215 (31%)
		ZnMc_adamalysin_II_like	211..408	CDD:239797	67/215 (31%)
		DISIN	427..501	CDD:214490	34/74 (46%)
		ACR	503..645	CDD:214743	53/153 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..797
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836137
Domainoid	1	1.000	89	1.000	Domainoid score	I7811
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850