DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and ADAM28

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_055080.2	Gene:	ADAM28 / 10863	HGNCID:	206	Length:	775	Species:	Homo sapiens

Alignment Length:	715	Identity:	229/715 - (32%)
Similarity:	342/715 - (47%)	Gaps:	101/715 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIK-AFNHKFR- 127
            |:::||::|....|     ||...|:..::                  ..|.|..| ..|.|..
Human    28 YEVVYPIRLHPLHK-----REAKEPEQQEQ------------------FETELKYKMTINGKIAV 69

  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
            |.|:.|..||:|...:.:|:..|..:..:...::.|||.|.:.:...:.|:..||.|:.|....|
Human    70 LYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQG 134

  Fly   193 NETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVV-EEILQA 256
            ::.:.|.|..........|.:|    |.|   .:..|.||          :.|:.||: ...||.
Human   135 DQRYFIEPLSPIHRDGQEHALF----KYN---PDEKNYDS----------TCGMDGVLWAHDLQQ 182

  Fly   257 GVG--------RNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLN 313
            .:.        ...|.|:|..||||..:::|...| ||....:.|:.....::||..::.::.||
Human   183 NIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEF-KRYNENQDEIRKRVFEMANYVNMLYKKLN 246

  Fly   314 TRVSVVYIETW-GKNQAVIDGSKDISKAISNFNDYTSRNLFQIER-DTTQLLTGETFAGGEAGMA 376
            |.|::|.:|.| .|::..|  :.:.|..:.||:.:....|.:.:| |..||:|....||...|:|
Human   247 THVALVGMEIWTDKDKIKI--TPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLA 309

  Fly   377 VPETVCTPRAVGISVDVNVYEPHLL--AGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIV 439
            ...|:|:|.:||:..|   :..:||  ||||||.:|||.||.|||  ..|.|.... |:|.:::
Human   310 FMSTMCSPYSVGVVQD---HSDNLLRVAGTMAHEMGHNFGMFHDD--YSCKCPSTI-CVMDKAL- 367

  Fly   440 GQENVQPYKFSECSKKDYIDALRTGHGLCLLNK--PNEIELRRNCGNKVVEEDEECDCGTFEECA 502
              ....|..||.||:..|..........||.|.  |.:|.....|||::||..|:|||||.|||.
Human   368 --SFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT 430

  Fly   503 LDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNG 567
             :.|||..|||:|:..|||.|.||::|:.:....:||.:.:||||||.|:|:.|.||.|.|:.||
Human   431 -NICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNG 494

  Fly   568 SPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIK 632
            .||...|    |:|..|.||||..||..:||.|...||:.||.: |..||..|:| |..::..|.
Human   495 FPCHHGK----GHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYC-RRVDDTLIP 553

  Fly   633 CEPENVQCGTLQCKDGERQPVNDGIDQL--YSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKD 695
            |:..:..||.|.|:.|.        |.|  ..|.:..:..:.|:.:.||.::        |:|.:
Human   554 CKANDTMCGKLFCQGGS--------DNLPWKGRIVTFLTCKTFDPEDTSQEI--------GMVAN 602

  Fly   696 GTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC--SSVV 758
            ||.||||.:|:|..||.:......|.|.:     :|..|.||.:..:|.|:.||...||  ||||
Human   603 GTKCGDNKVCINAECVDIEKAYKSTNCSS-----KCKGHAVCDHELQCQCEEGWIPPDCDDSSVV 662

Fly 759 758
Human 663 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	26/108 (24%)
		Reprolysin	270..473	CDD:279729	68/208 (33%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	67/204 (33%)
		Disintegrin	488..562	CDD:278623	37/73 (51%)
		ACR	566..713	CDD:214743	52/148 (35%)
ADAM28	NP_055080.2	Pep_M12B_propep	40..155	CDD:279848	30/137 (22%)
		Cysteine switch. /evidence=ECO:0000250	167..174		2/16 (13%)
		Reprolysin	204..399	CDD:279729	68/206 (33%)
		ZnMc_adamalysin_II_like	204..397	CDD:239797	67/204 (33%)
		Disintegrin	416..488	CDD:278623	37/72 (51%)
		ACR	493..620	CDD:214743	52/148 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..775
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950