DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and LOC103690152

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_008763105.3	Gene:	LOC103690152 / 103690152	RGDID:	9083574	Length:	723	Species:	Rattus norvegicus

Alignment Length:	675	Identity:	204/675 - (30%)
Similarity:	314/675 - (46%)	Gaps:	108/675 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 CYYHGTVKDYPGASAAFHTCN-GVSGVIHIGNETFVIHPFYGGDLSKH----PHVIFEARTKANK 222
            |||||.|:..|.:..||.:|: |..||:.:...::.|.|.      ||    .|:::.......:
  Rat   114 CYYHGYVEGAPESLVAFSSCSGGFQGVLQMNGFSYEIEPI------KHSSTFEHLVYTLNNNKTQ 172

  Fly   223 GCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMF--DK 285
            ......||..       |.|.....|:.|| .::.|.:|.|.:...|.::|.|::||...|  .:
  Rat   173 FPPMICNLTE-------KTLPDQPFGLKEE-EKSAVKQNYRKLWPHTWFLELAVVVDYNFFTYSQ 229

  Fly   286 RNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSR 350
            :|.|   :|..|.:.|.|:.|..::.::|.|::|.||.|  |:..:...::|.:.:.:|:.:...
  Rat   230 QNVS---KVRGDVVLVVNMVDSMYKQMDTYVNLVGIEIW--NRGNLLPMENIQQVLEDFSHWKQI 289

  Fly   351 NLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEP---HLLAGTMAHMIGHN 412
            :|.|:..|...:....:.. ...|:|....:|.|   .:...|..::.   .|.|.|:||.:||.
  Rat   290 SLSQVHHDAAHIFIRNSLI-SVLGIAYVAGICRP---PLDCGVENFQGDSWSLFANTVAHELGHT 350

  Fly   413 IGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLN--KPNE 475
            .||.||:  |.|.|.: .||:|:...|..|     :|:.||..|::.. ....|.||.|  :|..
  Rat   351 FGMRHDE--ESCSCGE-KGCVMSSFRVPAE-----RFTNCSHSDFMKT-TLNQGSCLYNHPRPGA 406

  Fly   476 IELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRD 540
            ..|.:.|||.:||.:||||||:..||..|.|| ...|.||..|.||.|.||..|:......:||.
  Rat   407 GFLVKRCGNGIVESEEECDCGSIRECEQDPCC-LFNCTLKPGAACAFGLCCKDCKFMLLGELCRA 470

  Fly   541 SNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAAD 605
            ..|||||||:|:|...|||.|.:.::|.||     |...||:|..|.....||..::|.|..:|.
  Rat   471 KINECDLPEWCNGTSHQCPEDGYVQDGVPC-----GARAYCYQKQCNGHDQQCREVFGKGARSAS 530

  Fly   606 RQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGE---RQPVNDGIDQLYSRTIIS 667
            ..||::.||:|:..||||.:... |:||...:|.||.:||::.|   ....:.....:|:..|
  Rat   531 HNCYKEINSQGTRFGHCGTNGTV-YLKCSVSDVLCGKIQCENVEDISHPQAHYAWQNIYASGI-- 592

  Fly   668 IKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECS 732
                  .|.:||..:|. ..|:.|.|||||.||...||:.:.||||      :..|.......|:
  Rat   593 ------TCWSTSHCLGM-GVPDVGEVKDGTACGIGKICVRKKCVSL------SALPNACLPETCN 644

  Fly   733 EHGVCTNTNRCFCDMGW----------GGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGT 787
            ..|:|.|.:.|.||.||          ||:..|.        ||    :|:.::.:
  Rat   645 GKGICNNRHHCHCDYGWSLPFCLHRGHGGSIDSG--------PT----SPKRSVDI--------- 688

  Fly   788 SDQNRISTLTMVIILTVIVKCVFIS 812
                .|.|:|::.:||    |:||:
  Rat   689 ----NILTITVLSVLT----CLFIA 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	18/54 (33%)
		Reprolysin	270..473	CDD:279729	56/209 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	55/205 (27%)
		Disintegrin	488..562	CDD:278623	36/73 (49%)
		ACR	566..713	CDD:214743	50/149 (34%)
LOC103690152	XP_008763105.3	Pep_M12B_propep	46..164	CDD:396235	18/55 (33%)
		ZnMc_adamalysin_II_like	212..400	CDD:239797	55/205 (27%)
		Disintegrin	419..491	CDD:395147	36/72 (50%)
		ACR	495..631	CDD:214743	50/150 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010