DRSC/TRiP Functional Genomics Resources

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Protein Alignment mmd and ADAM10

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_001101.1 Gene:ADAM10 / 102 HGNCID:188 Length:748 Species:Homo sapiens


Alignment Length:747 Identity:173/747 - (23%)
Similarity:251/747 - (33%) Gaps:234/747 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 IGGHYYQIIYPVQ--LRHHEKMGISTREVSLPKPGQRPR---PHDDSGFNRGRTKKHFHRTSLLI 119
            :||.|..   |:.  :||:|  |:|....||.:..||.:   .|:|...   |...|.|.     
Human    17 MGGQYGN---PLNKYIRHYE--GLSYNVDSLHQKHQRAKRAVSHEDQFL---RLDFHAHG----- 68

  Fly   120 KAFNHKFRLDLELNSQLLSPNIQQK--HYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC 182
            :.||.:.:.|..|.|.........|  .|.. .::..|:.:..|..:.||:|.|           
Human    69 RHFNLRMKRDTSLFSDEFKVETSNKVLDYDT-SHIYTGHIYGEEGSFSHGSVID----------- 121

  Fly   183 NGVSGVIHIGNETFVIHP---------------FYGGDLSKHPHVIFEARTKANKGCANSGNLDS 232
            ....|.|.....||.:.|               .|..|...:||     :.....|||     |.
Human   122 GRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPH-----KYGPQGGCA-----DH 176

  Fly   233 WRLSRRTKHLSAGVAGVVEEILQ------AGVG----RNKRDVREATK-----YIETAIIVDKAM 282
            ....|..|:...|    |||:.|      |..|    |.|| ...|.|     ||:|     ..:
Human   177 SVFERMRKYQMTG----VEEVTQIPQEEHAANGPELLRKKR-TTSAEKNTCQLYIQT-----DHL 231

  Fly   283 FDKRNGSTRAEVIHDAIQVANIADLY-------FRTLNTRVSVVYIETWGKNQAVIDGSKD---- 336
            |.|..|:..|.:...:..|..|..:|       .|.::..|..:.|.|..       ..||    
Human   232 FFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTA-------DEKDPTNP 289

  Fly   337 -------ISKAI-----SNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAV-- 387
                   :.|.:     .|.:||....:| .:||....:.|..:.|..:|.:  ..:|....:  
Human   290 FRFPNIGVEKFLELNSEQNHDDYCLAYVF-TDRDFDDGVLGLAWVGAPSGSS--GGICEKSKLYS 351

  Fly   388 ---------GISVDVNVYEPHLLAG----TMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQS-I 438
                     || :.|..|..|:...    |.||.:|||.|..||.|.|         |...:| .
Human   352 DGKKKSLNTGI-ITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTE---------CTPGESKN 406

  Fly   439 VGQENVQPY---------------KFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVE 488
            :||:....|               |||.||.::....|......|.:.....|     |||.:||
Human   407 LGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPI-----CGNGMVE 466

  Fly   489 EDEECDCGTFEECALDQCC------DGITCKLKSEAQC--ASGACCD-QCRLRPKDYICRDSNNE 544
            :.||||||..::|. |:||      :|..||||...||  :.|.||. ||..:.|...||| :::
Human   467 QGEECDCGYSDQCK-DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRD-DSD 529

  Fly   545 CDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCY 609
            |.....|:|....||:...|.|.:.|..                                     
Human   530 CAREGICNGFTALCPASDPKPNFTDCNR------------------------------------- 557

  Fly   610 EQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFE 674
               :::..|||.|.....|.|          |..:|....    :||.|......:..:|..:  
Human   558 ---HTQVCINGQCAGSICEKY----------GLEECTCAS----SDGKDDKELCHVCCMKKMD-- 603

  Fly   675 CKATSGQVGSNSYPEHG-----LVKDGTPCGD 701
             .:|....||..:..|.     .::.|:||.|
Human   604 -PSTCASTGSVQWSRHFSGRTITLQPGSPCND 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 25/123 (20%)
Reprolysin 270..473 CDD:279729 56/261 (21%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 56/259 (22%)
Disintegrin 488..562 CDD:278623 32/82 (39%)
ACR 566..713 CDD:214743 22/141 (16%)
ADAM10NP_001101.1 Pep_M12B_propep 46..156 CDD:396235 25/129 (19%)
Cysteine switch. /evidence=ECO:0000250 171..178 4/11 (36%)
ZnMc_TACE_like 220..459 CDD:239798 55/263 (21%)
DISIN 466..545 CDD:214490 31/80 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 704..748
SH3-binding. /evidence=ECO:0000255 708..715
SH3-binding. /evidence=ECO:0000255 722..728
Interaction with AP2A1, AP2A2 and AP2M1. /evidence=ECO:0000250|UniProtKB:O35598 734..748
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146056
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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