DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and LOC101884782

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_021334457.1	Gene:	LOC101884782 / 101884782	-ID:	-	Length:	760	Species:	Danio rerio

Alignment Length:	824	Identity:	241/824 - (29%)
Similarity:	383/824 - (46%)	Gaps:	114/824 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IANLILIIAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIY 69
            |.:|:|:|.  |:...:|..|...|.    |::...|  ::|.....|:.:         :.:.|
Zfish     6 IPDLLLLIC--CLLPPAAAAAAELLQ----NDDPASG--QQLNSSGPQDTQ---------HTLSY 53

  Fly    70 PVQLRH--HEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLEL 132
            |.:|.:  ||....:..:::.......||..:          .|..:||..::||..:|.|||.|
Zfish    54 PSRLIYYLHENSESTYHDLNTHAKTTDPRAQE----------AHLAQTSFQLQAFGSQFILDLTL 108

  Fly   133 NSQLLSPNIQQKHYH-------VGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIH 190
            |:.|||.:..:.||.       .||          |||||||.::....:..|..||||:.|:..
Zfish   109 NNDLLSSDYVEIHYEEEKPVLWKGG----------EHCYYHGQIRGVEDSRVALSTCNGLHGMFD 163

  Fly   191 IGNETFVIHPF---YGGDLSKHPHVIFEARTKANKGCANSGNLD--SWRLSRRTKHLSAGVAGVV 250
            .|...:.|.|.   :..:.:...||:.....:.:......|..:  || |.||.|.
Zfish   164 DGVHLYTIEPLNQTHTIEGTARAHVLHRTDLQQSPSAREEGMEEDFSW-LRRRKKR--------- 218

  Fly   251 EEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRT-LNT 314
                  .:.||   |.|..||||..|::|..||.:.  .|:....::|..|.|:.|..|:. |||
Zfish   219 ------AIPRN---VFEEMKYIELMIVIDHNMFKRL--KTKQHTRNNAKSVVNLVDAIFKEHLNT 272

  Fly   315 RVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPE 379
            ||.:|.:|.| .::..|..|....:.:.||:.|..:::.| ..||.||.:..||....:..|...
Zfish   273 RVVLVAVEIW-TDKDRIPVSVTPFEMLRNFSKYRQQHIRQ-HADTVQLFSNVTFHYPRSSAAYFG 335

  Fly   380 TVCT-PRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDG--REECFC-RDWHGCIMAQSIVG 440
            .:|: ...||:   :.......:|..::..:..|:|:..|..  |::|.| ..|.||||..:
Zfish   336 GMCSASHGVGV---IEYGTQWTMALQLSQSLAQNLGIQWDSASKRKDCGCVNSWPGCIMEDT--- 394

  Fly   441 QENVQ-PYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECALD 504
              .|| |..||:||...:.:.|..|.|.||.|||:::.....|||..||..||||||..:||..|
Zfish   395 --GVQHPRAFSKCSIVSFKEFLLKGGGSCLFNKPSKLFEDTECGNGYVEVGEECDCGPRDECYKD 457

  Fly   505 QCCDGITCKLKSEAQCASGACCDQ-CRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGS 568
             ||.  .|.|.:.|.|:.|.||:. |....:.:.||.:.|:||:.|.|.|:.|.||.::.|::|.
Zfish   458 -CCK--KCSLSNGAHCSDGPCCNNTCLFYSRGHTCRYAVNDCDISETCTGDSGLCPPNLHKQDGY 519

  Fly   569 PCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKC 633
            .|.|::    |.|:.|.|.|...||:.:||...:::::.|||:.|::||..|:||.|.:: :.:|
Zfish   520 FCSLNQ----GRCYAGECKTRDSQCKYVWGPKAASSEKFCYEKLNTEGSEKGNCGPDGDK-WTQC 579

  Fly   634 EPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTP 698
            ...:|.||.|.|.:..|.|....|....:.|..:.:|:..:|  :...|..:...:.|.|:||||
Zfish   580 SKHDVFCGFLLCTNTGRIPRIGIIKGEITPTNFNHQGRLIDC--SGAHVLLDDQTDVGYVEDGTP 642

  Fly   699 CGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTA 763
            ||.:::|:::.|:.: .:::.:.||....|..||.||||.|...|.||..|.|.|||
Zfish   643 CGPSMMCVDRKCLPI-QYLNLSSCPNGPNGHVCSSHGVCNNEATCTCDTTWAGMDCS-------- 698

  Fly   764 LPTEALPTPENTIKMEKKETPYGTSDQNR-ISTLTMVIILTVIV 806
                 |..|....:.::.|.|.|.|..|. |.::...|::..||
Zfish   699 -----LADPPKEPEPDEDEGPKGPSATNLIIGSIAGAILVAAIV 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	35/116 (30%)
		Reprolysin	270..473	CDD:279729	63/208 (30%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	62/206 (30%)
		Disintegrin	488..562	CDD:278623	31/74 (42%)
		ACR	566..713	CDD:214743	45/146 (31%)
LOC101884782	XP_021334457.1	Pep_M12B_propep	83..189	CDD:307618	35/125 (28%)
		Reprolysin	229..426	CDD:330960	63/208 (30%)
		Disintegrin	441..512	CDD:306668	31/73 (42%)
		ACR	516..657	CDD:214743	45/147 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010