DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam12

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_021336100.1	Gene:	adam12 / 101884222	-ID:	-	Length:	668	Species:	Danio rerio

Alignment Length:	675	Identity:	226/675 - (33%)
Similarity:	327/675 - (48%)	Gaps:	75/675 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSL--LIKAFNHKF 126
            :|::|.|..|...:               |||..|         .|...|..||  |||....:.
Zfish    46 HYEVIEPYLLIGGQ---------------QRPVSH---------IKSLGHPASLKVLIKVNGEQL 86

  Fly   127 RLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHI 191
            .|.|..|..|.:.:..:.||...|..|....:...||||||.|..:.|:.....||.|:.|:|.:
Zfish    87 LLALWKNEGLFASHYTETHYLEDGVAVTTLPNVTIHCYYHGEVMGHQGSDVTISTCTGLRGLISL 151

  Fly   192 GNETFVIHPFYGGDLSKHPHVIFEAR-TKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQ 255
            .:|.:|:.|...|    :.|.::..: .|..:|....|:    .:|:..:..:..|       ..
Zfish   152 EDEVYVLEPTQEG----NTHRLYRGQHLKLTQGTCGHGH----NISQPAEMFNTAV-------FS 201

  Fly   256 AGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVY 320
            :...|:|||.:.:||::|..|:.|...:.|: |....:|.....::||..|.::|:||.||::|.
Zfish   202 SHSARHKRDAQSSTKHVELIIVADNREYQKQ-GKDVEKVKQRLAEIANYVDKFYRSLNIRVALVG 265

  Fly   321 IETWGKNQAVIDGSK-----DISKAISNFNDYTSRNLFQIE-RDTTQLLTGETFAGGEAGMAVPE 379
            :|.|.      ||.|     |...::..|.|:....|..:. .|..||::|..|.|...|||...
Zfish   266 LEVWS------DGDKCSITQDPFTSLHEFLDWRKLKLLPLRAHDNAQLISGVYFQGTTIGMAPIM 324

  Fly   380 TVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCR---DWHGCIMAQSIVGQ 441
            ::||....|..|..:...|...|.|:||.:|||.||.||.....|.||   |..||||..| .|.
Zfish   325 SMCTAEQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTPERGCGCRATVDRGGCIMTPS-TGY 388

  Fly   442 ENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL---RRNCGNKVVEEDEECDCGTFEECAL 503
            .  .|..||.|||||...:|..|.|:||.|.| |:::   .:.|||..|||.|:||||..||| |
Zfish   389 P--FPTVFSTCSKKDLAASLEKGVGMCLFNMP-EVKVLYGGQKCGNGYVEEGEQCDCGDLEEC-L 449

  Fly   504 DQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGS 568
            :.||:..||.||.||.||.|.||:.|:|:|....||:|:|.|||||:|.|....||::|:..:|.
Zfish   450 NPCCNASTCTLKEEAVCAHGQCCENCQLKPAGTPCRESSNSCDLPEFCTGADPHCPANVYLHDGH 514

  Fly   569 PCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKC 633
            .|    .|:.|:|:.|.|.|...||..:||.|...|...|:|:.||.|...|:||:|....:.||
Zfish   515 SC----QGVDGHCYNGICQTHEQQCITLWGQGAKPAPGICFERVNSAGDPYGNCGKDTKGSFAKC 575

  Fly   634 EPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISI-KGQEFECKATSGQVGSNSYPEHGLVKDGT 697
            |..:.:||.:||:.|..:|| .|.:.:...|.|.: :|....|:.|...:| :..|:.|||..||
Zfish   576 EARDAKCGKIQCQGGANRPV-IGTNAVSIETNIPLQEGGRILCRGTHVYLG-DDMPDPGLVLTGT 638

  Fly   698 PCGDNL--ICLNQTCVSLFPHVDQT 720
            .||.|:  |.|.|:....:.:..||
Zfish   639 KCGQNMVKISLKQSLTKAYYNQTQT 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	33/108 (31%)
		Reprolysin	270..473	CDD:279729	74/211 (35%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	73/209 (35%)
		Disintegrin	488..562	CDD:278623	40/73 (55%)
		ACR	566..713	CDD:214743	52/149 (35%)
adam12	XP_021336100.1	Pep_M12B_propep	48..170	CDD:307618	40/149 (27%)
		Reprolysin	216..418	CDD:307535	74/211 (35%)
		DISIN	435..509	CDD:214490	40/74 (54%)
		ACR	512..645	CDD:214743	49/138 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010