DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam28.4

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_031754080.1	Gene:	adam28.4 / 101735040	XenbaseID:	XB-GENE-22167138	Length:	819	Species:	Xenopus tropicalis

Alignment Length:	708	Identity:	221/708 - (31%)
Similarity:	338/708 - (47%)	Gaps:	110/708 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YQIIYPVQLRHHEKMGISTREVSLPKPGQRP---RPHDDSGFNRGRTK------------KHFHR 114
            |:|:||..|:..|....:    |.|..|.||   .||...||..|..:            ||.|.
Frog    30 YEIVYPQILQAQENQAFT----SAPLEGHRPGLHHPHPPKGFTFGPPRNRRPGVHPRHPPKHRHP 90

  Fly   115 TSLLIKAFNHKFRLDLELNSQLLSPNIQQ------KHYHVGGYLVDGNRHDI-----EHCYYHGT 168
            ..|         :.:|:|:::.|..::::      :.|....||.||....|     :||||.|.
Frog    91 RML---------QYELQLDNKPLVLHLEKTEDLFFRDYTETRYLQDGTPTTISPVIKDHCYYQGR 146

  Fly   169 VKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCA---NSGNL 230
            |.:.|.:..:..||||:.|:|......|:|.|....|..:|....:|.:..:...|.   |:|..
Frog   147 VMNDPDSLVSLSTCNGLRGIITTKGRHFLIEPLSASDSEEHALYPYEPQEVSPTSCGVTYNNGGE 211

  Fly   231 DSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVI 295
            |.:|      .:|:..|...::||     |:|       ||::..::.|.:|:.|.|||  .|.|
Frog   212 DEFR------KMSSSFANQEDKIL-----RSK-------KYVQLYVVADNSMYLKYNGS--KETI 256

  Fly   296 HDAI-QVANIADLYFRTLNTRVSVVYIETW--GKNQAVIDGSKDISKAISNFNDYTSRNLF-QIE 356
            ...| ::.|..::.::.||...::..||.|  |...|::..||   ..::.|:.:..:.|. :.:
Frog   257 KQRIYEMVNYVNMVYKPLNVFAALCGIEIWDQGDQIAMLTNSK---VNLARFSAWREKVLLPRKQ 318

  Fly   357 RDTTQLLTGETFAGGEAGMAVPETVC-TPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDG 420
            .|..||:|...|.|...|:|....:| |.::.|:..|.|... .:|..|.||.:||::||.||.
Frog   319 NDLAQLITNINFDGPVVGIAYIGMICSTTQSAGVLQDHNKLS-IILGATSAHEMGHSLGMYHDG- 381

  Fly   421 REECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN--CG 483
             :.|.|...: |:|:..:   .:..|..||.||..::.:.|......||.:.|::..:...  ||
Frog   382 -KACACNKVY-CLMSTKL---SSWVPNTFSTCSINNFQEFLLNTRPTCLGDIPDKTNILTPPVCG 441

  Fly   484 NKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLP 548
            ||..|..|:|||||.:||. |||||..|||||..||||.|.||..|:::....:||:.|::|||.
Frog   442 NKFTEMGEDCDCGTVQECK-DQCCDAATCKLKPGAQCAEGECCSNCKIKAAGEVCRERNDDCDLE 505

  Fly   549 EYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFN 613
            :.|||....||||.|:.||:|||..:    |||:.|.|||:..||.::||......:..|:.: |
Frog   506 DVCDGTSPWCPSDRFQANGAPCGKGE----GYCYNGTCPTMQRQCTSLWGENTLVGEDLCFNK-N 565

  Fly   614 SKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKAT 678
            .:|:..||| ::....||.|:||||.||.|.|....:.|...|        .:::.|   ||||.
Frog   566 MEGTDYGHC-KNVGSTYIPCKPENVMCGVLYCNSDNKYPTVPG--------RVAVTG---ECKAL 618

  Fly   679 SGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGV 736
            ..       || |:|::|..|||..:|.|..|||:......:.|..     :||.:||
Frog   619 LA-------PE-GMVQNGIKCGDGKVCYNNECVSVETAFGLSGCEG-----KCSGNGV 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	32/129 (25%)
		Reprolysin	270..473	CDD:279729	58/207 (28%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	58/205 (28%)
		Disintegrin	488..562	CDD:278623	39/73 (53%)
		ACR	566..713	CDD:214743	52/146 (36%)
adam28.4	XP_031754080.1	Pep_M12B_propep	79..190	CDD:396235	31/119 (26%)
		ZnMc_adamalysin_II_like	233..425	CDD:239797	56/203 (28%)
		DISIN	446..520	CDD:214490	40/74 (54%)
		ACR	522..645	CDD:214743	52/147 (35%)
		Disintegrin	702..775	CDD:395147
		ADAM_CR	779..>808	CDD:417715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920