DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and LOC100910977

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_003751651.1	Gene:	LOC100910977 / 100910977	RGDID:	6495615	Length:	759	Species:	Rattus norvegicus

Alignment Length:	814	Identity:	225/814 - (27%)
Similarity:	352/814 - (43%)	Gaps:	178/814 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 QIIYPVQLRHHEKM-GISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLD 129
            :::.|:|:..:..| .:.....||...||                |||    :.:||  .||
  Rat    57 EVVIPLQVTGNRPMWAMGWLTYSLHFGGQ----------------KHF----IYMKA--KKF--- 96

  Fly   130 LELNSQLLSPNIQQKHYHVGGYLVDGNRHDIE-----HCYYHGTVKDYPGASAAFHTCN-GVSGV 188
              |.|:|||         |..|...|..|..:     .|||||.:...|....|..||: |..|:
  Rat    97 --LVSRLLS---------VFTYTKQGALHKDQPYVQKDCYYHGYMDGDPEFMVAITTCSGGFQGI 150

  Fly   189 IHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEI 253
            :.:....:.|.|       |:....||....              ::.|....|......:.|||
  Rat   151 LQVNGTVYEIKP-------KNLSATFEHLVH--------------KIDREGTELLPMRCALTEEI 194

  Fly   254 L-QAGVGRNKRDVREATKY---------IETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLY 308
            . |..:.:|:......:.|         ::.|:::|:......|.:: :.|:.:...:.||.:..
  Rat   195 ARQLKLQKNENLTLMQSHYEGWWTHKRFLDLALVIDRERIRYHNDNS-SHVLVEVFTIINIINKI 258

  Fly   309 FRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAGGE 372
            ::||:..:.::.:|.|.:...|...:.|:  .:..|..:.:|:| |:|..|...|.....| |..
  Rat   259 YQTLDLELVLLGVELWNERNHVPIHNIDV--LLYEFCIWKTRSLNFRIPNDIAHLFVNHHF-GIY 320

  Fly   373 AGMAVPETVCTP-------RAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWH 430
            .|:|...|||.|       |.:|.::   .|..|::    ||.:|||:||.||:|...|..:|
  Rat   321 LGLAYVGTVCMPSLNCGIDRLIGHNL---FYFGHII----AHEMGHNLGMQHDEGSCTCGAKD-- 376

  Fly   431 GCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDC 495
             |:||.:..|.:     |||.||...:.....|.:.:....||......:.|||.||::.|:|||
  Rat   377 -CLMAPTDSGIQ-----KFSNCSYSAFWTTYATANCMRKETKPLGSLKSKRCGNGVVDDGEQCDC 435

  Fly   496 GTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPS 560
            |:.|.||.|.||.. :|.||..|.||.|.||..||:.|...:||:..|||||||:|:|...:||:
  Rat   436 GSAEMCARDPCCKS-SCTLKDGATCAFGLCCTHCRVMPSGTVCREQVNECDLPEWCNGHSYKCPN 499

  Fly   561 DVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCG-- 623
            ||:..:||||   :.|  |||::..|...:.||:.|:|....:|.:.||.:.|::|...|:||
  Rat   500 DVYLLDGSPC---RGG--GYCYEKRCNNRNEQCKQIFGQEARSAAQSCYRELNTRGDRFGNCGMI 559

  Fly   624 RDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTII---SIKGQEFECKATSGQVGSN 685
            |||   |::|...::.||.|||::      ..||..|...:.:   .:.|  ..|..|....|.
  Rat   560 RDA---YLRCHDSDILCGRLQCEN------VTGIPLLQDHSTVHWTRLNG--VTCWGTDYHFGM- 612

  Fly   686 SYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGW- 749
            :.|:.|.|||||.|....:|:|:.||:....:.|  |...:    |:..|||.|.:.|.||:||
  Rat   613 TIPDVGFVKDGTDCSPEHVCINRKCVNKSIWISQ--CSPKT----CNMKGVCNNLHHCHCDLGWD 671

  Fly   750 ---------GGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVI 805
                     ||:..|..:.|....|.|:             ..|              ||::.::
  Rat   672 PPYCLESGFGGSVDSGPLHLKEEKPKES-------------RKP--------------VILICIL 709

  Fly   806 VKC---VFISFATLAVCYRRKTTTLKYDPPYSKK 836
            ..|   :||.|..|.:.|        .:.|.||:
  Rat   710 FACFSLLFIVFLFLLISY--------VNQPKSKE 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	30/112 (27%)
		Reprolysin	270..473	CDD:279729	54/219 (25%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	54/217 (25%)
		Disintegrin	488..562	CDD:278623	36/73 (49%)
		ACR	566..713	CDD:214743	50/151 (33%)
LOC100910977	XP_003751651.1	Pep_M12B_propep	69..176	CDD:279848	37/163 (23%)
		ZnMc_adamalysin_II_like	221..398	CDD:239797	52/195 (27%)
		Disintegrin	428..501	CDD:278623	36/73 (49%)
		ACR	504..640	CDD:214743	50/152 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2908
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.900