Protein Alignment mmd and adam28.3

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_031755156.1
• Gene: adam28.3 / 100498252
• XenbaseID: XB-GENE-22167131
• Length: 674
• Species: Xenopus tropicalis
• Alignment Length: 679
• Identity: 196/679 - (28%)
• Similarity: 311/679 - (45%)
• Gaps: 91/679 - (13%)

  Fly   123 NHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEH-CYYHGTVKDYPGASAAFHTCNGVS 186
            |....|.||....|:..:..:..|...| :...||.:::. |.|.|.||..|.:..:..||||:|
 Frog    62 NRPLVLHLEKTEGLIHNDFTETRYQQDG-MRTTNRPEVKDLCLYQGQVKGDPHSLVSLSTCNGLS 125

  Fly   187 GVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGC-ANSGNLDSWRLSRRTKHLSAGVAGVV 250
            |.|.....||:|.|....|..:|....::.:...:|.| ..|.|:.....:         .|...
 Frog   126 GSIMTQGHTFLIEPLKETDSEEHAFYEYDPKADTSKACGVTSSNMPEGEFN---------TASYT 181

  Fly   251 EEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAI-QVANIADLYFRTLNT 314
            .::.:      |:::..::||::..::.|.:|..|.|||  .|.|.:.| |:.|..::.::.||.
 Frog   182 MDLTE------KQEILNSSKYVQLYVVADYSMVQKYNGS--VETIKNRIFQMMNYNNMVYKALNV 238

  Fly   315 RVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIE-RDTTQLLTGETFAGGEAGMAVP 378
            .:::..:|.| :|..........::.:.||:::..:||...: .|....||...|.....|:|..
 Frog   239 FIALCGVEFW-ENGDQFPVPSPANECLGNFSEWRDKNLVPRKLHDAAVFLTNVKFVAPLVGLAYV 302

  Fly   379 ETVCTPR-AVGISVDVNVY--EPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVG 440
            ..:|..| :.|:   :|.|  |..::|..:||.:|||.||.||.  .:|.|.. ..|||::.:
 Frog   303 GGMCFGRFSAGV---INDYSKEATIVASIIAHEVGHNFGMNHDS--TDCSCSS-ASCIMSKYV-- 359

  Fly   441 QENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN--CGNKVVEEDEECDCGTFEECAL 503
             ..|.|..||.||...:.:.|.|.:..|:.:.|::.::...  ||||..|..|:|||||.:||.
 Frog   360 -SPVAPTLFSNCSISAFQNFLLTKNPTCISDIPDKPDILTPPVCGNKFTEVGEDCDCGTVQECK- 422

  Fly   504 DQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGS 568
            :.|||..|||.|...||..|.|||.|.::...::||.|..:|||.:.|:|....||||.|:.||.
 Frog   423 NPCCDAATCKKKPNVQCTGGECCDNCMIKAAGHVCRASKGDCDLDDLCNGVSSSCPSDRFRVNGL 487

  Fly   569 PCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKC 633
            ||...:    |||:.|.|||:..||.||||...:.:...|: ..|:.|.|.|||.::... |:.|
 Frog   488 PCNNGR----GYCYNGSCPTMLNQCNAIWGVDSAVSGNSCF-NMNTNGVIYGHCKQNGTT-YVPC 546

  Fly   634 EPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTP 698
            ..|::.||.|.|.:|...|       |.|...::...    |||.....|.        |:.|..
 Frog   547 AAEDIMCGVLFCINGTTFP-------LISAPFVTTPA----CKALLSPAGK--------VQSGAK 592

  Fly   699 CGDNLICLNQTCVSL-FPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTT 762
            ||:..:|.|..||:. ..::..:.|.:     :|.::.||.:...|.|..||...:|:  |.:|:
 Frog   593 CGNGKVCSNNQCVTTETAYIGSSGCDS-----KCPKNAVCDHELICQCTKGWVPPNCN--VAVTS 650

  Fly   763 ALPTEALPTPENTIKMEKKETPYGTSDQN 791
            .:                    ..|||||
 Frog   651 GV--------------------ISTSDQN 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	28/91 (31%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	58/205 (28%)
		Disintegrin	488..561	CDD:459709	33/72 (46%)
		ACR	566..713	CDD:214743	47/146 (32%)
adam28.3	XP_031755156.1	Pep_M12B_propep	31..150	CDD:460254	28/88 (32%)
		ZnMc_adamalysin_II_like	195..389	CDD:239797	58/205 (28%)
		DISIN	408..482	CDD:214490	35/74 (47%)
		ACR	485..605	CDD:214743	45/144 (31%)