DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam23

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001233135.1	Gene:	adam23 / 100494499	XenbaseID:	XB-GENE-988267	Length:	815	Species:	Xenopus tropicalis

Alignment Length:	872	Identity:	258/872 - (29%)
Similarity:	397/872 - (45%)	Gaps:	142/872 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCVFVTSAGE---ADYTLDDSFWNEE--SPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLR 74
            ||:.:.|..:   |..|...|.|||.  |..|   ||.:|.:.:.....|...
Frog    32 LCLLLLSCPQHWGALSTQTASHWNETAGSTAG---RLTEEDQSSHNNNSRSDS------------ 81

  Fly    75 HHEKMGISTREVSLP--------KPGQRP------RPHDDSGFNRGRTKKHFHRTSLLIKAFNHK 125
            .|.:.....:|:::|        |..:.|      :..|....|:.   .|..:.|..|:||...
Frog    82 IHSQNNAIQKEITMPSRLVYYINKESESPYHVLDTKARDQPKHNKA---VHLAQASFQIEAFGST 143

  Fly   126 FRLDLELNSQLLSPNIQQKHYHVG-GYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVI 189
            |.|||.||:.|||.:..:..|..| ..|..|.    |||||||:::....:..|..||||:.|:.
Frog   144 FILDLTLNNGLLSLDYSEIEYSDGKPKLTKGG----EHCYYHGSIRGVNNSRVAISTCNGLHGMF 204

  Fly   190 HIGNETFVIHPF---YGGDLSKHPHVIFEARTKANKGCANSGNL--------------DSWRLSR 237
            ..|..|:.|||.   :....:..||:|  .||..::...:..:|              ..|...|
Frog   205 DDGTYTYTIHPVDITHSSKSTSRPHII--ERTAGSQISVHQDSLAESEEKVNSHKTPPTEWLRKR 267

  Fly   238 RTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVA 302
            |.:.|.| ..|:.||:                ||:|..|:.|..|: |::.|:.....:.|..|.
Frog   268 RKRALPA-PRGIFEEM----------------KYVELMIVNDHQMY-KKHRSSHMYTNNFAKSVV 314

  Fly   303 NIAD-LYFRTLNTRVSVVYIETW-GKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTG 365
            |:.| :|...|||||.:|.:||| .|::..|  |.|..|.:.:|:.|...::.| ..|...||:.
Frog   315 NLVDSVYKEQLNTRVVLVAVETWTDKDRIPI--SPDPIKMLHDFSKYRQHHIKQ-HADAVHLLSN 376

  Fly   366 ETFAGGEAGMAVPETVCT-PRAVGISVDVNVYEPHL-LAGTMAHMIGHNIGMGHDDG--REECFC 426
            .||....:.|:....||: .|.||    ||.|...| :|..:|..:..|:|:..:..  :.:|.|
Frog   377 GTFHYKRSSMSYFGGVCSITRGVG----VNEYGLLLSMAQQLAQSLAQNLGIQWEPASRKSKCDC 437

  Fly   427 -RDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEED 490
             .::.||||.::.|....    :||:||..:|.:.|..|.|.||.|:|.::.....|||..||..
Frog   438 TENFGGCIMEETGVYHSR----RFSKCSIAEYKEFLNRGGGSCLFNRPTKLFEVTECGNGYVEAG 498

  Fly   491 EECDCGTFEECALDQCCDGITCKLKSEAQCASGACCD-QCRLRPKDYICRDSNNECDLPEYCDGE 554
            ||||||...:|..| ||.  .|.|.:.|.|:.|.||: .|...|::|.||.:.||||:.|:|.|:
Frog   499 EECDCGFRMDCFGD-CCK--KCSLSNGAHCSDGPCCNTSCLFLPREYDCRYAVNECDITEHCTGD 560

  Fly   555 IGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSIN 619
            .||||.::.|::|:.|..::    |.|:.|.|.|...||:.|||...:.:|:.|||:.|::|:..
Frog   561 SGQCPPNLRKQDGNACDSNQ----GRCYNGECKTRDNQCKHIWGTKAAGSDKFCYEKLNTEGTEK 621

  Fly   620 GHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGS 684
            |:||:| .:.:|:|...:|.||.|.|.:..:.|....::.....|.|:.:|:..:|  :...|..
Frog   622 GNCGKD-GDRWIQCSKHDVFCGFLLCANVSKSPRIGKLEGDIPPTYINHQGRVVDC--SGAHVIL 683

  Fly   685 NSYPEHGLVKDGTPCGDNLICLNQTCVSLFPH-VDQTKCPANSQGLECSEHGVCTNTNRCFCDMG 748
            :...:.|.|:||.|||.:::||::.|:.:  | ::.:.||..|.|..||.||||:|...|.|...
Frog   684 DDETDMGYVEDGAPCGPSMMCLDRKCLPI--HLLNISNCPFGSNGKVCSGHGVCSNEATCICSST 746

  Fly   749 WGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISF 813
            |.|.|||                    |...|||.|....|..::|..|     ..::..|..:.
Frog   747 WAGTDCS--------------------IYDPKKEPPTKKDDLPKVSMAT-----NRLIGAVAGTI 786

  Fly   814 ATLAVCYR------RKTTTLKYDPPYS 834
            ..|.|.:.      ......:|||..|
Frog   787 LALGVIFGGTGWGIENVKKRRYDPSQS 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	38/110 (35%)
		Reprolysin	270..473	CDD:279729	67/209 (32%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	66/207 (32%)
		Disintegrin	488..562	CDD:278623	34/74 (46%)
		ACR	566..713	CDD:214743	45/146 (31%)
adam23	NP_001233135.1	Pep_M12B_propep	129..231	CDD:279848	38/105 (36%)
		Reprolysin	283..481	CDD:279729	67/209 (32%)
		ZnMc_adamalysin_II_like	283..479	CDD:239797	66/207 (32%)
		Disintegrin	496..568	CDD:278623	34/74 (46%)
		ACR	571..712	CDD:214743	45/147 (31%)
		DUF3844	729..797	CDD:289707	25/92 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9442
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0002073
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010