Protein Alignment mmd and adam23

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_001233135.1
• Gene: adam23 / 100494499
• XenbaseID: XB-GENE-988267
• Length: 815
• Species: Xenopus tropicalis
• Alignment Length: 872
• Identity: 258/872 - (29%)
• Similarity: 397/872 - (45%)
• Gaps: 142/872 - (16%)

  Fly    15 LCVFVTSAGE---ADYTLDDSFWNEE--SPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLR 74
            ||:.:.|..:   |..|...|.|||.  |..|   ||.:|.:.:.....|...
 Frog    32 LCLLLLSCPQHWGALSTQTASHWNETAGSTAG---RLTEEDQSSHNNNSRSDS------------ 81

  Fly    75 HHEKMGISTREVSLP--------KPGQRP------RPHDDSGFNRGRTKKHFHRTSLLIKAFNHK 125
            .|.:.....:|:::|        |..:.|      :..|....|:.   .|..:.|..|:||...
 Frog    82 IHSQNNAIQKEITMPSRLVYYINKESESPYHVLDTKARDQPKHNKA---VHLAQASFQIEAFGST 143

  Fly   126 FRLDLELNSQLLSPNIQQKHYHVG-GYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVI 189
            |.|||.||:.|||.:..:..|..| ..|..|.    |||||||:::....:..|..||||:.|:.
 Frog   144 FILDLTLNNGLLSLDYSEIEYSDGKPKLTKGG----EHCYYHGSIRGVNNSRVAISTCNGLHGMF 204

  Fly   190 HIGNETFVIHPF---YGGDLSKHPHVIFEARTKANKGCANSGNL--------------DSWRLSR 237
            ..|..|:.|||.   :....:..||:|  .||..::...:..:|              ..|...|
 Frog   205 DDGTYTYTIHPVDITHSSKSTSRPHII--ERTAGSQISVHQDSLAESEEKVNSHKTPPTEWLRKR 267

  Fly   238 RTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVA 302
            |.:.|.| ..|:.||:                ||:|..|:.|..|: |::.|:.....:.|..|.
 Frog   268 RKRALPA-PRGIFEEM----------------KYVELMIVNDHQMY-KKHRSSHMYTNNFAKSVV 314

  Fly   303 NIAD-LYFRTLNTRVSVVYIETW-GKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTG 365
            |:.| :|...|||||.:|.:||| .|::..|  |.|..|.:.:|:.|...::.| ..|...||:.
 Frog   315 NLVDSVYKEQLNTRVVLVAVETWTDKDRIPI--SPDPIKMLHDFSKYRQHHIKQ-HADAVHLLSN 376

  Fly   366 ETFAGGEAGMAVPETVCT-PRAVGISVDVNVYEPHL-LAGTMAHMIGHNIGMGHDDG--REECFC 426
            .||....:.|:....||: .|.||    ||.|...| :|..:|..:..|:|:..:..  :.:|.|
 Frog   377 GTFHYKRSSMSYFGGVCSITRGVG----VNEYGLLLSMAQQLAQSLAQNLGIQWEPASRKSKCDC 437

  Fly   427 -RDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEED 490
             .::.||||.::.|....    :||:||..:|.:.|..|.|.||.|:|.::.....|||..||..
 Frog   438 TENFGGCIMEETGVYHSR----RFSKCSIAEYKEFLNRGGGSCLFNRPTKLFEVTECGNGYVEAG 498

  Fly   491 EECDCGTFEECALDQCCDGITCKLKSEAQCASGACCD-QCRLRPKDYICRDSNNECDLPEYCDGE 554
            ||||||...:|..| ||.  .|.|.:.|.|:.|.||: .|...|::|.||.:.||||:.|:|.|:
 Frog   499 EECDCGFRMDCFGD-CCK--KCSLSNGAHCSDGPCCNTSCLFLPREYDCRYAVNECDITEHCTGD 560

  Fly   555 IGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSIN 619
            .||||.::.|::|:.|..::    |.|:.|.|.|...||:.|||...:.:|:.|||:.|::|:..
 Frog   561 SGQCPPNLRKQDGNACDSNQ----GRCYNGECKTRDNQCKHIWGTKAAGSDKFCYEKLNTEGTEK 621

  Fly   620 GHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGS 684
            |:||:| .:.:|:|...:|.||.|.|.:..:.|....::.....|.|:.:|:..:|  :...|..
 Frog   622 GNCGKD-GDRWIQCSKHDVFCGFLLCANVSKSPRIGKLEGDIPPTYINHQGRVVDC--SGAHVIL 683

  Fly   685 NSYPEHGLVKDGTPCGDNLICLNQTCVSLFPH-VDQTKCPANSQGLECSEHGVCTNTNRCFCDMG 748
            :...:.|.|:||.|||.:::||::.|:.:  | ::.:.||..|.|..||.||||:|...|.|...
 Frog   684 DDETDMGYVEDGAPCGPSMMCLDRKCLPI--HLLNISNCPFGSNGKVCSGHGVCSNEATCICSST 746

  Fly   749 WGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISF 813
            |.|.|||                    |...|||.|....|..::|..|     ..::..|..:.
 Frog   747 WAGTDCS--------------------IYDPKKEPPTKKDDLPKVSMAT-----NRLIGAVAGTI 786

  Fly   814 ATLAVCYR------RKTTTLKYDPPYS 834
            ..|.|.:.      ......:|||..|
 Frog   787 LALGVIFGGTGWGIENVKKRRYDPSQS 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	39/113 (35%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	66/207 (32%)
		Disintegrin	488..561	CDD:459709	34/73 (47%)
		ACR	566..713	CDD:214743	45/146 (31%)
adam23	NP_001233135.1	Pep_M12B_propep	109..231	CDD:460254	41/128 (32%)
		Reprolysin	283..481	CDD:426256	67/209 (32%)
		Disintegrin	496..567	CDD:459709	34/73 (47%)
		ACR	571..712	CDD:214743	45/147 (31%)