DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam11

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001243157.1	Gene:	adam11 / 100491446	XenbaseID:	XB-GENE-966539	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	840	Identity:	269/840 - (32%)
Similarity:	382/840 - (45%)	Gaps:	148/840 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VTSAGEADYTLDDSFWN---------EESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLR 74
            |.||..|.:.|..|..|         .:||        |.:.|..:        :.||.:|.:|.
Frog    13 VISANAAMHPLGSSLVNTIVPPITAHSDSP--------KRWYQKLD--------HTQITHPSRLV 61

  Fly    75 HHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSP 139
            .|.. |..|....|....:...|:|...        |....|.|:.....|..||||||..|||.
Frog    62 GHTS-GAETHRYQLNTRVRSENPNDQDA--------HVAHASFLVTFLEKKMILDLELNHLLLSS 117

  Fly   140 NIQQKHYHV--GGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPF- 201
            ...::||..  ..|:..|.... :||||.|.::....:.||..||:|:||....|..|:.|:|.
Frog   118 KYVERHYDEDNNSYVKTGGTSG-DHCYYQGKLRGVEDSWAAISTCHGLSGAFSDGVYTYTIYPLK 181

  Fly   202 YGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVR 266
            ...:..|.||.|...:......|.                        :..|:.....|.||.||
Frog   182 QSTETEKWPHAIERIKKCTEPDCE------------------------LHTIIPGSKIRRKRQVR 222

  Fly   267 EA-------TKYIETAIIVDKAMFDKRNGSTRAEVI---HDAIQVANIADLYFR-TLNTRVSVVY 320
            ..       |||:|..::.|:.:||::    |..|:   ..|..|.|:||:.|| .||||:.:|.
Frog   223 RTSHSALTETKYVELMVVNDRYLFDQQ----RQSVVLTSSFAKSVVNLADVIFREQLNTRIVLVG 283

  Fly   321 IETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPR 385
            :|||..... |.||:|..:.:..|..|....:.. ..|||.|.:|.||....:|.|....:|:|.
Frog   284 METWTSTDK-ITGSEDPLQVLDEFMRYRRAEILD-HSDTTHLFSGRTFKSSRSGAAYFGGICSPS 346

  Fly   386 AVGISVDVNVY-EPHLLAGTMAHMIGHNIGMGHDDGRE---ECFCRD-WHGCIMAQSIVGQENVQ 445
            ..|   .||.| ...::|.|:|..:|.|:||..:..|.   :|.|.| |.||||..:    ....
Frog   347 HGG---GVNEYGNIGVMAVTLAQTLGQNLGMMWNKLRTTAGDCKCPDLWLGCIMEDT----GYYL 404

  Fly   446 PYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEEC---ALDQCC 507
            |.|||.||..:|...|:.|.|.||.|||.::....:|||..||..||||||:..||   ....||
Frog   405 PQKFSRCSVDEYSQFLQDGGGSCLFNKPLKLLDPPSCGNGFVELGEECDCGSPAECNKSGAGNCC 469

  Fly   508 DGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGL 572
            .  .|.|..:|.|:.|.||..|:..|:..:||.|.||||:||.|.|:...||:::.|::|..|..
Frog   470 K--KCTLSHDAMCSDGLCCRGCKYEPRGTVCRGSLNECDVPETCPGDSSVCPANLHKQDGYFCDN 532

  Fly   573 SKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPEN 637
            .:    |.||.|.|.|...||.|:|  |.||:||.|||:.|.:|:..|:|||| .:::|:|..::
Frog   533 EQ----GRCFGGRCKTRDRQCHALW--GRSASDRFCYEKLNIEGTEKGNCGRD-RQNWIQCSKQD 590

  Fly   638 VQCGTLQCKDGERQPVNDGIDQL--YSRTIISI----KGQEFECKATSGQVGSNSYPEH---GLV 693
            |.||.|.|.:      ..||.|:  .:..|.|:    :.:..:|:  .|||   ..|:.   |.|
Frog   591 VLCGYLLCSN------ISGIPQIGELNGDITSMSFYHQNRYLDCR--GGQV---MLPDGSCLGYV 644

  Fly   694 KDGTPCGDNLICLNQTCV--SLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSS 756
            :||||||.|::||.:.|:  |.|   :.:.||.:..|:.||:||||:|..:|.|...|.|.|||.
Frog   645 EDGTPCGPNMMCLERRCLPASAF---NFSTCPGSWNGVICSDHGVCSNEGKCICHPEWTGKDCSV 706

  Fly   757 VVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATL 816
            .         :.||.|:.|..:||.:.|.||:           ||:..|...|.|:...|
Frog   707 Y---------DPLPIPKPTGVVEKYKGPSGTN-----------IIIGSIAGAVLIAAIVL 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	36/109 (33%)
		Reprolysin	270..473	CDD:279729	73/211 (35%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	72/209 (34%)
		Disintegrin	488..562	CDD:278623	33/76 (43%)
		ACR	566..713	CDD:214743	56/157 (36%)
adam11	NP_001243157.1	Pep_M12B_propep	<116..193	CDD:366707	24/77 (31%)
		Reprolysin	233..432	CDD:366632	73/211 (35%)
		Disintegrin	447..521	CDD:365943	33/75 (44%)
		ACR	525..663	CDD:214743	56/155 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9442
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7614
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0002073
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020