DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mmd and adam28.1

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_001233133.1 Gene:adam28.1 / 100488450 XenbaseID:XB-GENE-982024 Length:780 Species:Xenopus tropicalis


Alignment Length:826 Identity:254/826 - (30%)
Similarity:371/826 - (44%) Gaps:171/826 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 YYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRL 128
            ||::::|.::....|     |:|.    |..|.. ...|.:.|  .||      ||        |
 Frog    28 YYEVVFPKKIHAQHK-----RDVQ----GMYPEV-VQYGIHMG--GKH------LI--------L 66

  Fly   129 DLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGN 193
            .||.|..|||.|..:.:|...|..|..:.....||||.|.||:..|:.|:..||:|:.|:|....
 Frog    67 HLEKNEDLLSANYTETYYLSDGTPVTTSPKIQNHCYYQGNVKNDNGSLASISTCSGLRGLIQTEG 131

  Fly   194 ETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVV--EEIL-- 254
            :.::|.|.  .|.....|.::||:.:..|.|                    ||....  |||:  
 Frog   132 QMYLIEPL--KDTDSESHAVYEAQMETPKTC--------------------GVDNTTYREEIVVK 174

  Fly   255 --QAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGS-TRAEVIHDAIQVANIADLYFRTLNTRV 316
              ::|....::.:.:|.|||...::.|.:||.|.|.| |..::  ...:|.|..::.::.:||.|
 Frog   175 KSRSGSSAEQQQILKAQKYIRLVVVADNSMFIKYNKSITNVKI--RIFEVINFVNVVYKAINTFV 237

  Fly   317 SVVYIETWGKN---QAVIDGSKDISKAISNFNDYTSRNLF-QIERDTTQLLTGETFAGGEAGMAV 377
            :::.||.|...   :.|...|.|::.    |.|:....|. :...|..||||...|.|...|:|.
 Frog   238 ALIGIEVWNTTDQFKVVTSASADLAA----FADWRKNVLLRRTPNDNAQLLTNTDFDGATVGLAY 298

  Fly   378 PETVCTPRAVGISVDVNVYEPHLLA-----GTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQS 437
            ..|.|:.     :....|.:.|..|     .|:||.:|||:||.||  .:.|.| ....||||..
 Frog   299 VGTECSE-----THSAGVIQDHSKASIGVGATVAHELGHNLGMNHD--TDSCSC-SASSCIMAPY 355

  Fly   438 IVGQENVQ-PYKFSECSKKDYIDALRTGHGLCLLNKP--NEIELRRNCGNKVVEEDEECDCGTFE 499
            :    :|. |..||.||.::|.|.|.:....|:|..|  .:|.....||||..|..|:|||||.|
 Frog   356 L----SVNTPRLFSSCSLQNYQDFLLSRMPQCMLAVPLKEDIIAPAVCGNKFTEIGEDCDCGTVE 416

  Fly   500 ECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFK 564
            ||. :||||..||||||.|:||.|.|||.|:::....:||.:.::|||.:.|||:...||||.|:
 Frog   417 ECT-NQCCDAATCKLKSTAKCAEGDCCDNCQIKKAGSVCRAAKDDCDLADMCDGKSSVCPSDRFR 480

  Fly   565 KNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEH 629
            .||.||...|    ||||.|.|||...||..:||.....::..|: ..|::|...|:|.. |...
 Frog   481 VNGFPCSNGK----GYCFNGKCPTHQSQCTTLWGASSVPSEDSCF-NVNTRGVDYGYCTM-AGAT 539

  Fly   630 YIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVK 694
            |:.|:|::|:||.|.|..|..||           :|.:...:...|:|...|        .|:|:
 Frog   540 YVPCKPKDVKCGMLFCYGGSSQP-----------SIYAAVAEFSRCRAVLAQ--------GGMVQ 585

  Fly   695 DGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVL 759
            :||.|||.::|.|..|.|:......|.|.|     :||.|.||.:...|.|:.||          
 Frog   586 NGTKCGDGMVCYNGACSSIESAYRSTNCSA-----QCSGHAVCDHEMLCQCEEGW---------- 635

  Fly   760 LTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKT 824
               |.||..:.:|.|.|                |..:.:||.|.:::..||     ||..||.| 
 Frog   636 ---APPTCDVASPTNII----------------IIVVVIVIALALVIGLVF-----LARFYRGK- 675

  Fly   825 TTLKYDPPYSKKPIAKSYGGAATAPNHHSVEEVSLDGSSKLVYANQ 870
                     .||..:.|:  .||         |:::||:...:.||
 Frog   676 ---------GKKQSSSSF--PAT---------VTVEGSTNPSFRNQ 701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 34/106 (32%)
Reprolysin 270..473 CDD:279729 65/213 (31%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 64/211 (30%)
Disintegrin 488..562 CDD:278623 39/73 (53%)
ACR 566..713 CDD:214743 48/146 (33%)
adam28.1NP_001233133.1 Pep_M12B_propep 30..150 CDD:366707 41/147 (28%)
ZnMc_adamalysin_II_like 192..385 CDD:239797 64/210 (30%)
Disintegrin 405..477 CDD:365943 38/72 (53%)
ACR 482..601 CDD:214743 47/143 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm48880
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X50
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.020

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