DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and XB990656

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_004915886.2	Gene:	XB990656 / 100486640	XenbaseID:	XB-GENE-990657	Length:	791	Species:	Xenopus tropicalis

Alignment Length:	715	Identity:	214/715 - (29%)
Similarity:	318/715 - (44%)	Gaps:	108/715 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHR---TSLL--IKAFNH 124
            |:|::| ||       :.|||                     |...|:..   .:||  |:...|
Frog    25 YEIVFP-QL-------VGTRE---------------------RRDLHYEEQWSDNLLYSIQTLTH 60

  Fly   125 KFRLDLELNSQLLSPNIQQKHY-HVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGV 188
            |..|.|:.|..|:|...::..| ...|:.|..:.....:|||:|.|:....:..|..||:|:.||
Frog    61 KLLLKLQRNRDLVSSGFERFTYSKEAGFQVFNSTQLSHNCYYYGEVEGMNDSLLAISTCDGLRGV 125

  Fly   189 IHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEI 253
            :::....:.|.|....  :...|.:|:.:..:.......|::|:     .:.|....|
Frog   126 MYMAEMHYGIEPVENS--TNGEHRLFQIQEPSGPSICGVGDIDT-----ESSHSPLPV------- 176

  Fly   254 LQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGS-TRAEVIHDAIQVANIADLYFRTLNTRVS 317
             ...:.|.||.|.....|:|..::||...:...|.: |..||  :.:.:.||.|..||.||.|:.
Frog   177 -NFRLRRAKRSVLTTPSYVELGVVVDNLRYQADNSNMTAVEV--ETVLLINIVDSMFRYLNIRIV 238

  Fly   318 VVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVC 382
            ::.:..:.:|......|......:..|.::.::|......|.:.||.|....|...|||...|||
Frog   239 LISLTVFDQNNPFDVQSGTAGDVLGRFTNWKNQNTGLKRTDISHLLIGRGSYGAVIGMAFVGTVC 303

  Fly   383 TPRAVGISVDVNV------YEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQ 441
            :|     |||.::      ..|...|..:||.:|||:||.|||    ..|..  |.||..:.:|.
Frog   304 SP-----SVDTSISAFSAGKTPQAHAPVVAHELGHNLGMSHDD----TTCPG--GYIMYSADIGA 357

  Fly   442 ENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRR--NCGNKVVEEDEECDCGTFEECALD 504
            :|     ||.||..|:.:.:..|.|.||.|.||..::..  .|||.:||..||||||:.:||. :
Frog   358 KN-----FSSCSATDFENLILRGGGACLKNLPNPSQVLSIPTCGNNIVETGEECDCGSPQECQ-N 416

  Fly   505 QCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSP 569
            .||...||||.|.::|..|.||:.|:.:.....||...:.|||||||:|....||.|.:..||.|
Frog   417 PCCQAATCKLTSGSKCGQGLCCENCQFKVAGTPCRSIADTCDLPEYCNGTYALCPVDEYIMNGFP 481

  Fly   570 CGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCE 634
            |..|:    .||:.|.|.....||..::|.....|..||::|.|..|...|:||...|: |.||.
Frog   482 CNNSR----NYCYSGVCQNYDAQCRNLFGKDTRKAVDQCFQQANLLGDQYGNCGMAGND-YKKCA 541

  Fly   635 PENVQCGTLQCKDGERQPVNDG-IDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTP 698
            ..:..||.||| .|..||:.:| :..|::.     :...|.|.:.....|.: .|:.|||..||.
Frog   542 TVDSLCGKLQC-TGNPQPILNGKVQSLFAN-----QDPSFPCLSVDFNQGPD-VPDPGLVHQGTS 599

  Fly   699 CGDNLICLNQTCVSLFPHVDQTKCPANSQG------LECSEHGVCTNTNRCFCDMGWGGNDCSSV 757
            |||.|.|:|..||:           |.:.|      .:|::.|||.|...|.|:.||....|..|
Frog   600 CGDGLACVNYACVN-----------ATNLGYNCDVKTKCNDRGVCNNNGNCHCNYGWAPPYCDRV 653

Fly 758 757
Frog 654 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	29/112 (26%)
		Reprolysin	270..473	CDD:279729	63/209 (30%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	62/207 (30%)
		Disintegrin	488..562	CDD:278623	33/73 (45%)
		ACR	566..713	CDD:214743	52/147 (35%)
XB990656	XP_004915886.2	Pep_M12B_propep	26..146	CDD:396235	35/150 (23%)
		ZnMc_adamalysin_II_like	193..382	CDD:239797	62/206 (30%)
		DISIN	401..475	CDD:214490	34/74 (46%)
		ACR	477..613	CDD:214743	51/147 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020