DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam15

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_031747227.1	Gene:	adam15 / 100145641	XenbaseID:	XB-GENE-5944438	Length:	878	Species:	Xenopus tropicalis

Alignment Length:	792	Identity:	238/792 - (30%)
Similarity:	373/792 - (47%)	Gaps:	126/792 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 MGISTREVSLPKPGQRPRPHDDSGFN---RGRTKKHFHRTSL--LIKAFNHKFRLDLELNSQLLS 138
            :|:|||:.::   ..|.....||...   ..|..:..||..|  .::......::.:|::.:.:.
Frog    18 LGLSTRDRAV---SHRVAVQPDSPLYWEVTPRLHRSGHRLGLQEAMQILPDDLQISMEIDGEQVQ 79

  Fly   139 PNIQQKHYHVGG------YLVDGNR-----HDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
            .::::..:.|.|      ||.:|:|     ..:.:|||.|.::...|..::...|:|:.|:|...
Frog    80 LDLERNRHLVPGSHRLIYYLPNGSRVTDQDPGVANCYYQGQLEGQTGPWSSLSLCSGIRGIIMTS 144

  Fly   193 NET-FVIHPFYGGDLSKHPHVI-FEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQ 255
            .|. |.|.|. .||.| |.|:: .......|..|.||          .|.||..|..|...   :
Frog   145 PERGFSIEPL-PGDPS-HKHIVRLTQENPKNSSCGNS----------ETPHLLTGTIGTQS---R 194

  Fly   256 AGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVY 320
            ....|.||||....|::|.|::.|...:...:|..:...|. .:::||..|.::|.||.||::|.
Frog   195 EPHHRTKRDVVTERKFVELAMVADNREYKLLHGDMKGLHIR-MLEIANKVDAFYRPLNVRVALVA 258

  Fly   321 IETWG-KNQAVIDGSKDISKAISNFNDYTSRNLFQ-IERDTTQLLTGETFAGGEAGMAVPETVCT 383
            :|.|. |:|  |:.|.:.::.:..|..:..|:|.. :..|..|||||.||.....|||...::|:
Frog   259 VEVWNQKDQ--INISTNPAETLYRFLSWRERSLLPLVANDNAQLLTGLTFKNSSVGMATLNSMCS 321

  Fly   384 P-RAVGISVDVNVYEPHLL--AGTMAHMIGHNIGMGHDDGREECFC------RDWHGCIMAQS-- 437
            . .:.|:|:|.:|   .:|  |.|:||.:|||:|:.||..|:   |      :.|   ||..|
Frog   322 SGGSGGVSMDHSV---SILGVASTLAHQLGHNLGLSHDTDRK---CGQPSKGKKW---IMEPSAG 377

  Fly   438 -IVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL--RRNCGNKVVEEDEECDCGTFE 499
             :.|.|      ||.||..|...:||.|.|:||.|.|....|  ...|||.:|||.|:||||..:
Frog   378 FLPGLE------FSNCSLADLEFSLRRGGGMCLFNVPPPKRLFGEPQCGNFLVEEGEQCDCGLTQ 436

  Fly   500 ECALDQCCDGITCKLKSEAQCASG-ACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVF 563
            :|. |.|||...|:|:|.|||:|| .||:.|:|:...::||:....|||||||:||...||.:|:
Frog   437 DCR-DPCCDASLCQLRSGAQCSSGDQCCEGCKLKVSGWMCREPLGACDLPEYCNGESPHCPPNVY 500

  Fly   564 KKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANE 628
            .:||..|.      .|||::|.|.||..||..:||.|.:.|...|:.:.|.:|...|:|||..:.
Frog   501 LQNGETCD------QGYCYRGECRTLRAQCLDVWGPGSAPAPDPCFSKVNVRGDKYGNCGRSPDG 559

  Fly   629 HYIKCEPENVQCGTLQCKDGE-RQPVNDGIDQLYSRTI---ISIKGQEFECKATSGQVGSNSYPE 689
            .|:.|...:|.||.:||:.|. |..:..|     ::|:   ::|.|.|..|:.|...:|.:.:..
Frog   560 TYLPCAESDVWCGKIQCQGGSARSRLGAG-----AQTVLVSVTINGSELSCRGTHFDLGDDIWDS 619

  Fly   690 HGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC 754
            ..||..|||||...:|:.|.|      .|.::....:...:|:..|||.:.:.|.||.||...||
Frog   620 AVLVATGTPCGTGKVCIGQKC------EDVSRLKVQNCRNKCNGRGVCNSNSNCHCDPGWAPPDC 678

  Fly   755 ------SSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISF 813
                  .|:                      ...:..|..|.:.::...:|:.|.|:...|.
Frog   679 VGSGQGGSI----------------------DSGSLSGRPDGSSVTAALLVLFLLVVPLLVL--- 718

  Fly   814 ATLAVCYRRKTT 825
              |.:||.::.|
Frog   719 --LGICYIKRDT 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	29/120 (24%)
		Reprolysin	270..473	CDD:279729	71/216 (33%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	70/214 (33%)
		Disintegrin	488..562	CDD:278623	37/74 (50%)
		ACR	566..713	CDD:214743	50/150 (33%)
adam15	XP_031747227.1	Pep_M12B_propep	43..164	CDD:396235	29/122 (24%)
		ZnMc_adamalysin_II_like	209..406	CDD:239797	70/214 (33%)
		DISIN	425..500	CDD:214490	37/75 (49%)
		ACR	502..643	CDD:214743	50/157 (32%)
		EGF_2	655..678	CDD:400365	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8218
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48880
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000