Protein Alignment mmd and adam15

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_031747227.1
• Gene: adam15 / 100145641
• XenbaseID: XB-GENE-5944438
• Length: 878
• Species: Xenopus tropicalis
• Alignment Length: 792
• Identity: 238/792 - (30%)
• Similarity: 373/792 - (47%)
• Gaps: 126/792 - (15%)

  Fly    79 MGISTREVSLPKPGQRPRPHDDSGFN---RGRTKKHFHRTSL--LIKAFNHKFRLDLELNSQLLS 138
            :|:|||:.::   ..|.....||...   ..|..:..||..|  .::......::.:|::.:.:.
 Frog    18 LGLSTRDRAV---SHRVAVQPDSPLYWEVTPRLHRSGHRLGLQEAMQILPDDLQISMEIDGEQVQ 79

  Fly   139 PNIQQKHYHVGG------YLVDGNR-----HDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
            .::::..:.|.|      ||.:|:|     ..:.:|||.|.::...|..::...|:|:.|:|...
 Frog    80 LDLERNRHLVPGSHRLIYYLPNGSRVTDQDPGVANCYYQGQLEGQTGPWSSLSLCSGIRGIIMTS 144

  Fly   193 NET-FVIHPFYGGDLSKHPHVI-FEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQ 255
            .|. |.|.|. .||.| |.|:: .......|..|.||          .|.||..|..|...   :
 Frog   145 PERGFSIEPL-PGDPS-HKHIVRLTQENPKNSSCGNS----------ETPHLLTGTIGTQS---R 194

  Fly   256 AGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVY 320
            ....|.||||....|::|.|::.|...:...:|..:...|. .:::||..|.::|.||.||::|.
 Frog   195 EPHHRTKRDVVTERKFVELAMVADNREYKLLHGDMKGLHIR-MLEIANKVDAFYRPLNVRVALVA 258

  Fly   321 IETWG-KNQAVIDGSKDISKAISNFNDYTSRNLFQ-IERDTTQLLTGETFAGGEAGMAVPETVCT 383
            :|.|. |:|  |:.|.:.::.:..|..:..|:|.. :..|..|||||.||.....|||...::|:
 Frog   259 VEVWNQKDQ--INISTNPAETLYRFLSWRERSLLPLVANDNAQLLTGLTFKNSSVGMATLNSMCS 321

  Fly   384 P-RAVGISVDVNVYEPHLL--AGTMAHMIGHNIGMGHDDGREECFC------RDWHGCIMAQS-- 437
            . .:.|:|:|.:|   .:|  |.|:||.:|||:|:.||..|:   |      :.|   ||..|
 Frog   322 SGGSGGVSMDHSV---SILGVASTLAHQLGHNLGLSHDTDRK---CGQPSKGKKW---IMEPSAG 377

  Fly   438 -IVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL--RRNCGNKVVEEDEECDCGTFE 499
             :.|.|      ||.||..|...:||.|.|:||.|.|....|  ...|||.:|||.|:||||..:
 Frog   378 FLPGLE------FSNCSLADLEFSLRRGGGMCLFNVPPPKRLFGEPQCGNFLVEEGEQCDCGLTQ 436

  Fly   500 ECALDQCCDGITCKLKSEAQCASG-ACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVF 563
            :|. |.|||...|:|:|.|||:|| .||:.|:|:...::||:....|||||||:||...||.:|:
 Frog   437 DCR-DPCCDASLCQLRSGAQCSSGDQCCEGCKLKVSGWMCREPLGACDLPEYCNGESPHCPPNVY 500

  Fly   564 KKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANE 628
            .:||..|.      .|||::|.|.||..||..:||.|.:.|...|:.:.|.:|...|:|||..:.
 Frog   501 LQNGETCD------QGYCYRGECRTLRAQCLDVWGPGSAPAPDPCFSKVNVRGDKYGNCGRSPDG 559

  Fly   629 HYIKCEPENVQCGTLQCKDGE-RQPVNDGIDQLYSRTI---ISIKGQEFECKATSGQVGSNSYPE 689
            .|:.|...:|.||.:||:.|. |..:..|     ::|:   ::|.|.|..|:.|...:|.:.:..
 Frog   560 TYLPCAESDVWCGKIQCQGGSARSRLGAG-----AQTVLVSVTINGSELSCRGTHFDLGDDIWDS 619

  Fly   690 HGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC 754
            ..||..|||||...:|:.|.|      .|.::....:...:|:..|||.:.:.|.||.||...||
 Frog   620 AVLVATGTPCGTGKVCIGQKC------EDVSRLKVQNCRNKCNGRGVCNSNSNCHCDPGWAPPDC 678

  Fly   755 ------SSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISF 813
                  .|:                      ...:..|..|.:.::...:|:.|.|:...|.
 Frog   679 VGSGQGGSI----------------------DSGSLSGRPDGSSVTAALLVLFLLVVPLLVL--- 718

  Fly   814 ATLAVCYRRKTT 825
              |.:||.::.|
 Frog   719 --LGICYIKRDT 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	29/127 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	70/214 (33%)
		Disintegrin	488..561	CDD:459709	37/73 (51%)
		ACR	566..713	CDD:214743	50/150 (33%)
adam15	XP_031747227.1	Pep_M12B_propep	43..164	CDD:460254	29/122 (24%)
		ZnMc_adamalysin_II_like	209..406	CDD:239797	70/214 (33%)
		DISIN	425..500	CDD:214490	37/75 (49%)
		ACR	502..643	CDD:214743	50/157 (32%)