DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam28.2

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001120446.1	Gene:	adam28.2 / 100145537	XenbaseID:	XB-GENE-5949648	Length:	783	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	238/820 - (29%)
Similarity:	368/820 - (44%)	Gaps:	170/820 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKF 126
            |..|::::|.:|...:|     |:.....|                :..|:.     ::......
Frog    29 GQKYEVVFPKKLHFQQK-----RDTQSKYP----------------STVHYE-----VQLEGEPL 67

  Fly   127 RLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDI-----EHCYYHGTVKDYPGASAAFHTCNGVS 186
            .|.||....|:|     :||....||.||...:.     :||||.|.|::...:..:...|:|:|
Frog    68 VLKLEKTEDLIS-----EHYTETQYLPDGTPIETSPEIQDHCYYQGGVENDSSSLLSISACSGLS 127

  Fly   187 GVIHIGNETFVIHPFYGGDLSKHPHVIFEAR--TKANKGCANS----GNLDSWRLSRRTKHLSAG 245
            |:|......::|.|....|..:|....::|:  |....|..|:    ||..      :|...::.
Frog   128 GIIQTRGRRYLIEPLKQTDSEEHAVFPYQAQESTPVTCGVTNTTYMEGNFS------KTSLATSN 186

  Fly   246 VAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFR 310
            .|.|  |.|            ::.||||..::.||:||:|...||. .|.....::.|..::.::
Frog   187 AAKV--EFL------------KSKKYIELYMVADKSMFNKYGRSTE-NVKRRIFEIVNFVNVVYK 236

  Fly   311 TLNTRVSVVYIETWGKNQAVIDGSKDISKA---ISNFNDYTSRNLF-QIERDTTQLLTGETFAGG 371
            .:|..|::..||.|.|:    ||...:|.|   :..|:|:.::||. :...|..|.:|...|.|.
Frog   237 QINIFVALTGIEVWDKS----DGFTVVSSADEDLKLFSDWRTKNLLPRKAHDNAQFITHIDFDGS 297

  Fly   372 EAGMAVPETVCTPRAVGISVDVNVYEPH-----LLAGTMAHMIGHNIGMGHDDGREECFCRDWHG 431
            ..|:|...|:|:..:     ...|.:.|     .:..|:||.:|||:|:.||:.  .|.| ....
Frog   298 TVGLAYVGTMCSSTS-----STGVIQDHSQQSIAIGATVAHEMGHNLGINHDEA--HCTC-STGS 354

  Fly   432 CIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN--CGNKVVEEDEECD 494
            |||..::...   .|.:||.||.::|.|.:.....||:.:.|.:.|::..  ||||..|..||||
Frog   355 CIMEPALSFN---TPREFSLCSHQNYQDFILQKMPLCMKDVPKKTEIQTPPVCGNKFTELGEECD 416

  Fly   495 CGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCP 559
            ||:..||. :.||:..|||||:.||||.|.|||.|:......:||...::|||.|.|||:..:||
Frog   417 CGSISECT-NPCCNATTCKLKAGAQCAEGQCCDSCKWTKAGTVCRSKRHDCDLAEMCDGQSAECP 480

  Fly   560 SDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGR 624
            ||.|:.||.||   :.| .|||:.|.||||...|.|:||.....||..|: .:|.:|:.||:| :
Frog   481 SDRFRVNGFPC---RNG-EGYCYNGLCPTLQGLCSALWGPSSVVADDSCF-NYNLRGANNGYC-Q 539

  Fly   625 DANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPE 689
            |:..:.:.|:..:|:||.|.|..|...|...|         ..|:|   |||.|       .||.
Frog   540 DSKGNQVPCKQSDVKCGVLYCSGGYSTPNLGG---------YYIRG---ECKTT-------LYPT 585

  Fly   690 HGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC 754
            . ||::||.||||::|....|.|:......:.|.|     :|.||.||.:.|:|.|:.||...||
Frog   586 F-LVENGTKCGDNMVCFMGECTSIQTAFGPSDCDA-----KCPEHAVCDHENQCRCEEGWAPPDC 644

  Fly   755 SSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVC 819
            :                                   |...|.|:::::.:|  ||.:.|..|.|.
Frog   645 A-----------------------------------NFTGTNTIIVVVAII--CVIVLFILLFVW 672

  Fly   820 Y----RRKTTTLK------YDPPYS--KKPIAKSYGGAAT 847
            :    |||..|.:      .:|.::  :||...:...|||
Frog   673 FKWSSRRKQRTSRTRVTGAVNPAFNVREKPWGPAGSNAAT 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	27/111 (24%)
		Reprolysin	270..473	CDD:279729	61/211 (29%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	61/209 (29%)
		Disintegrin	488..562	CDD:278623	37/73 (51%)
		ACR	566..713	CDD:214743	53/146 (36%)
adam28.2	NP_001120446.1	Pep_M12B_propep	33..153	CDD:366707	32/150 (21%)
		ZnMc_adamalysin_II_like	197..391	CDD:239797	61/209 (29%)
		Disintegrin	410..482	CDD:365943	36/72 (50%)
		ACR	487..608	CDD:214743	53/146 (36%)
		PHA03247	<677..779	CDD:223021	10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48880
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020