DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and XB5838589

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_002933016.3	Gene:	XB5838589 / 100145070	XenbaseID:	XB-GENE-5838590	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	505	Identity:	109/505 - (21%)
Similarity:	187/505 - (37%)	Gaps:	129/505 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIIAQLCVFVTS--AGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQ 72
            |::|.:.:..|.  |.|.|:...|  |:.|...                        |:||.|::
Frog    20 LVMAGIALLATGLIATEQDWYKQD--WSSELQA------------------------YEIIDPLK 58

  Fly    73 LRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLL 137
            ::                             :||:|:.  .:.:.||:.......|.|:...:.:
Frog    59 IQ-----------------------------SRGQTEN--EKVTFLIRTEEKPLLLRLKQKRESV 92

  Fly   138 SPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFY 202
            ..|::...|.....|:....:..:.|||||.|:.||.:|.:..:|.|:.|.|...|.::.|.|.
Frog    93 LSNMKVFTYGKDNKLIADEPYMQDSCYYHGFVEGYPESSVSLSSCTGLRGFIQYENFSYRIEPL- 156

  Fly   203 GGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVRE 267
             ..|....|:::.:..:.       ||| :..|:.:||..|..::..|.  .:.|
Frog   157 -DPLRTSKHIMYRSENRV-------GNL-ACGLNFKTKTPSLQLSSPVS--YRGG---------- 200

  Fly   268 ATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVID 332
            ...|||.|::|....:  |.....::::.:..::.|:.|..|:::|.|:.::.||.|......:.
Frog   201 EPMYIEFAVVVSNNWY--RQVQNISQIVSEITEMVNLMDDMFQSINIRIILIAIEVWTNENFSVA 263

  Fly   333 GSKDISKAISNFNDYTSRNL----------FQIERDTTQLLTGETFAGGEAGMAVPETVCT---P 384
            .|......::.||.:..|..          |.|:|            ...|||......|.   .
Frog   264 SSSSGEHILTEFNKWKQREFVHRVFSDIEGFVIDR------------APSAGMGYTGNACKKSFS 316

  Fly   385 RAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGH--DDGREECFCRDWHGCIMAQSIVGQENVQPY 447
            .:..:....:|.|..|:   .||.:||::||.|  |:..|.|.   .|.|.|..          .
Frog   317 HSFAVFKHFDVVERALI---FAHNLGHSLGMEHDTDESCENCI---MHCCAMYN----------L 365

  Fly   448 KFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGT 497
            .|||.|....|.....|..|||.|:|: .|...|.||.:  ..:.||.|:
Frog   366 SFSEQSHSALIAEDIGGKLLCLKNEPS-TESLFNSGNWM--HGKYCDRGS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	27/106 (25%)
		Reprolysin	270..473	CDD:279729	51/217 (24%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	50/215 (23%)
		Disintegrin	488..562	CDD:278623	3/10 (30%)
		ACR	566..713	CDD:214743
XB5838589	XP_002933016.3	Pep_M12B_propep	59..167	CDD:396235	28/140 (20%)
XB5838589	XP_002933016.3	ZnMc_adamalysin_II_like	203..389	CDD:239797	50/215 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020