DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam22

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_021322679.1	Gene:	adam22 / 100126805	ZFINID:	ZDB-GENE-070810-1	Length:	978	Species:	Danio rerio

Alignment Length:	1086	Identity:	305/1086 - (28%)
Similarity:	467/1086 - (43%)	Gaps:	224/1086 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLRHH 76
            |:.||:|::|......:|        :..|:.   |.:.|..::..|.:|   .:...||:|.:.
Zfish    12 ISLLCLFMSSVVHTSMSL--------AHYGDA---LVKTRARRDDARYLG---KENTVPVRLVYQ 62

  Fly    77 EKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNI 141
            ..   ..|:.:......|.|...||..|      |..:.|..::||...|.||:|||..|||.|.
Zfish    63 MD---GDRQTAHDAVNTRIRMRSDSKQN------HVAQASFQVQAFGQTFILDVELNHDLLSSNY 118

  Fly   142 QQKHYHVGGYLV--DGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGG 204
            .::|....|..|  .|.    |||||||.|:|.|.:..|..||:|:.|:...||.|::|.|  ||
Zfish   119 IERHLSEEGKPVVSKGG----EHCYYHGKVRDVPKSYVALSTCHGLHGMFFDGNHTYMIEP--GG 177

  Fly   205 DLSK----HPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAG------VAGVVEEILQAGVG 259
            :.:.    |.|::::           |.:||:........||:..      :........:..:.
Zfish   178 ENTTSEEVHVHMVYQ-----------SHSLDTSEDFISPVHLAESLFENPPLFSAAHRRKKRQIS 231

  Fly   260 RNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFR-TLNTRVSVVYIET 323
            ||.|.|.:.|||:|..:|.|..|:.|...|. .:..:.|..|.|:|||||: .||||:.:|.:||
Zfish   232 RNPRSVEDETKYVELMVINDHLMYKKHRLSV-GQTNNYAKSVVNMADLYFKEQLNTRIVLVAMET 295

  Fly   324 WGKNQAVIDGSKDISKAISNFND---YTSRNLFQIER-------DTTQLLTGETFAGGEAGMAVP 378
            |..:...            |.||   .|.|...:..|       |:..|.:|..|.....|.:..
Zfish   296 WAADNRF------------NINDDPMVTLREFMKYRRDFIKEKCDSVHLFSGNRFHSNWGGASYM 348

  Fly   379 ETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGR---EECFCRD-WHGCIMAQSIV 439
            ..||:....|   .||.|... :|.|:|..:|.|||:..|..|   .||.|.| |.||||..  |
Zfish   349 GGVCSLTKGG---GVNEYGKE-MAITLAQSLGQNIGIFSDKKRILNGECKCEDKWSGCIMDD--V 407

  Fly   440 GQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECAL- 503
            |  ...|.:||:|:.:::.|.|.:|.|.||.|||:::.....|||..||..||||||:..|||.
Zfish   408 G--FYLPERFSDCNVEEFHDFLNSGGGACLFNKPSKLLDPPECGNGFVEAGEECDCGSPAECAKE 470

  Fly   504 -DQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNG 567
             :.||.  .|.|...|:|:.|.||..|:|.....:||::.|:||:||.|.|...|||.::.|.:|
Zfish   471 GENCCK--KCMLTQGAKCSDGLCCKNCQLEFMGVLCREAVNDCDIPEMCTGNSSQCPPNLHKMDG 533

  Fly   568 SPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIK 632
            ..|...:    |.||.|.|.|...||:.:||...::||:.|||:.|.:|:..|:|||| .:.:|:
Zfish   534 YTCEKDQ----GRCFNGRCKTKDRQCKYLWGEKATSADKFCYEKLNIEGTEKGNCGRD-KDTWIQ 593

  Fly   633 CEPENVQCGTLQCKD-------GERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEH 690
            |:.::|.||.|.|.:       ||.|   .|:      |..|:.........:.|.|..:...:.
Zfish   594 CKKQDVHCGYLLCSNISPAPRLGELQ---GGL------TSFSVAQHSASLDCSGGHVLIDGDTDL 649

  Fly   691 GLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCS 755
            |.|:|||.||.:.||.|..|:.: ...:.:.||..::.:.||.||||:|..||.|::||.|.||:
Zfish   650 GYVEDGTACGTDRICFNHKCLPV-QDFNFSTCPGTNERVICSGHGVCSNELRCVCELGWAGEDCN 713

  Fly   756 SVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVC- 819
            :...|:..|   ..||.:.:                  ..:|..||:..|...:.:....|.:.
Zfish   714 ATSPLSYLL---VRPTAKTS------------------GIITTNIIIGAIAGSILVLALILGISA 757

  Fly   820 --YR--RKTTTLKYD---------PP--YSKKP-------------IAKSYGGAATAP----NHH 852
              |:  |:...::.|         ||  |.|||             ::.:.|.::...    :|.
Zfish   758 WGYKTYRQRQYVESDVHRRFCRPMPPGDYVKKPGDADSLYSDMPQGVSSNSGSSSKKRSAYLSHL 822

  Fly   853 SVEEVSLDGSSKLVYANQT--GFRDKGIHGRRYTTCGEDDQSHAEKGILKKHGYGLVHGEQLKDK 915
            .:...|...|...:..|.:  |||..|:             ||:             ..|::.|
Zfish   823 QINTCSFTPSIPSISQNISLFGFRSNGL-------------SHS-------------WSERIPD- 860

  Fly   916 WGDDNQSDNLELITQDGTLASTSGGAAASEVERTLKSLNGYHEDILEALRNAATHRGTGTGNTPV 980
                  :.::..:.::|...|.|.   ...:..|.|.|.|..   ..|..|:..:.      ||.
Zfish   861 ------AKHISDVCENGRPRSNSW---QGNITGTRKKLKGKK---FRARSNSTEYL------TPC 907

  Fly   981 GSGSLSEEMLRKTLQDCNNSQLG------YSAEQYKRNIGSKSSSR 1020
            ..   ||..:.|.::|.|.:..|      ..|:....:.||.:|||
Zfish   908 VK---SEYYVTKWVEDVNKNTEGPYIRTLSPAKSPTSSTGSIASSR 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	42/112 (38%)
		Reprolysin	270..473	CDD:279729	72/217 (33%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	71/215 (33%)
		Disintegrin	488..562	CDD:278623	33/75 (44%)
		ACR	566..713	CDD:214743	50/153 (33%)
adam22	XP_021322679.1	Pep_M12B_propep	74..191	CDD:307618	47/128 (37%)
		Reprolysin	242..439	CDD:330960	72/217 (33%)
		Disintegrin	454..527	CDD:306668	33/74 (45%)
		ACR	531..672	CDD:214743	50/154 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8993
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2271
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0002073
OrthoInspector	1	1.000	-	-		otm25091
orthoMCL	1	0.900	-	-		OOG6_103986
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860