DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8924 and BTBD18

DIOPT Version :9

Sequence 1:	NP_573091.1	Gene:	CG8924 / 32557	FlyBaseID:	FBgn0030710	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001138573.1	Gene:	BTBD18 / 643376	HGNCID:	37214	Length:	712	Species:	Homo sapiens

Alignment Length:	479	Identity:	103/479 - (21%)
Similarity:	162/479 - (33%)	Gaps:	121/479 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AFPQLLAGQR---FVDVTLACEGQQVHCHRLVLAACSTYF-EAILAEHPCKHPVIILP-REIKLW 81
            ||.||...|:   |.||.|..||:.|..|..:|:|||.:| |.:..|.|.:...::|. ..:|:.
Human    20 AFLQLHHQQQSDVFCDVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKIS 84

  Fly    82 EIQALVDFMYKGEVNVTQAGLGQLLRCAEQLQIRGLYGSEAPINYKKLQQASLEAAKDPAATTAR 146
            .::.||||:|..|:.|:|.....:|..|.||::            .:|:...||..|...|...|
Human    85 TLRKLVDFLYTSEMEVSQEEAQDVLSAARQLRV------------SELESLQLEGGKLVKAPQGR 137

  Fly   147 SFKHVDSAETDDAATNSTTSTTMTTSSAPPLPVNHQQPTVLKRQNPDARQQQQQQQQQQVQQRPQ 211
            .... :..:...||..|....|.:.....|||.| |.|..|......:..:::..|:...|....
Human   138 RLNR-ECLQPTSAAPISARVVTPSHHPHTPLPTN-QTPCPLGAIRLKSLGKEEGPQENNRQNADN 200

  Fly   212 INGSNAQQ------PSKATSTNVLGSHSNAPTEDDSGDEVPNNWNAYGEQFDDCNISAQAVDNKM 270
            ::|:...:      |:.....:...|||..|.|           |......|...:|..::...:
Human   201 LSGTLLLKRKARACPTPQEKNSSPSSHSQEPRE-----------NKNDTALDPTVLSPPSLYPSV 254

  Fly   271 NVHLSLQQARMQMQLQQQQYLDSNVEDDHNYVAAHDENNDSSFATG---VPCGSG------LSLS 326
            :.||..::.|:...........|               ..||..:|   ||...|      .|::
Human   255 DKHLLPRKIRLSRSKPSPGICTS---------------KPSSILSGSSSVPATPGRRLWRQRSVN 304

  Fly   327 LDT-----------DLDTSANTSGGLSHSSIDGYTSYKRVRRSE--------ASLAQAAKC---- 368
            .:|           .|.::.|.||       .|.|...|.|..|        |...|..:.
Human   305 KETPEDKPKPGRASPLQSTPNPSG-------LGKTGGSRKRSPEVRAPNSDSAEEGQVGRVKLRK 362

  Fly   369 VSKGETFQTVSNM-----------------FNIPVSTIRFYMARKGILPKRKRGRGASHAGNIII 416
            :..|..::.|...                 |..|..|..|....:.:.|.|..           :
Human   363 IVNGTCWEVVQETPLKNTQDSPQIPDPGGDFQEPSGTQPFSSNEQEMSPTRTE-----------L 416

  Fly   417 TTNS---GKLSTVPASITHPPAHP 437
            ..:|   .||..:..|.:|.|.||
Human   417 CQDSPMCTKLQDILVSASHSPDHP 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8924	NP_573091.1	BTB	25..117	CDD:279045	33/96 (34%)
		BTB	34..117	CDD:197585	29/84 (35%)
		MerR	378..407	CDD:278788	7/45 (16%)
BTBD18	NP_001138573.1	BTB	24..120	CDD:306997	32/107 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..176		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..355		31/175 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..410		4/35 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..676
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910