DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8924 and fru

DIOPT Version :9

Sequence 1:	NP_573091.1	Gene:	CG8924 / 32557	FlyBaseID:	FBgn0030710	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster

Alignment Length:	795	Identity:	157/795 - (19%)
Similarity:	257/795 - (32%)	Gaps:	334/795 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QEFCVRWNSHLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHP 70
            |:||:|||:|..::......||..:...||||||||:.|..|:.:|:|||.|||.|..::...||
  Fly   109 QQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHP 173

  Fly    71 VIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAEQLQIRGL-------YGSE------- 121
            :|.| ::::..|:::|:||||||||||.|:.|...|:.||.||:|||       |.|:
  Fly   174 IIYL-KDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKLRDS 237

  Fly   122 --------APINY--------------------------------------KKLQQASLEAAKDP 140
                    .|.||                                      ..:.:.|..||...
  Fly   238 AASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERSSAAAAAA 302

  Fly   141 AATTA--------------------------------------------------RS-------- 147
            ||..|                                                  ||
  Fly   303 AAAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRSASADGCSD 367

  Fly   148 ---------------------FKHVDSAETDDAAT---NSTTSTTMTTSSAPPLPVNHQQPTVLK 188
                                 :.:.|:..::.::|   |:..:.....||:.    |:...:..:
  Fly   368 RGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNNSSSN----NNNSSSNRE 428

  Fly   189 RQNPDARQQQQQQQQQQVQQR-----PQINGSNAQQPSKATSTN----VLGSHSNAPTEDDS--- 241
            |.|...|::::::::::.:.|     |....|::::..|.:|:|    :..||.:.....||
  Fly   429 RNNSGERERERERERERDRDRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQDSQAN 493

  Fly   242 --GDEVPNNWNAYGEQFD--------------------DCNISAQAVDNKMNVHLSLQQARMQMQ 284
              ...||....:..|..|                    ..|:.|.:..:.::..||::|..|..|
  Fly   494 FKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGLSQSLSIKQELMDAQ 558

  Fly   285 LQQQ----------QYLDS-----NVEDDHNYVAAH--------DENNDSSFATGVPCGSGLSLS 326
            .|||          .||.|     :.||....:..|        ||:||:.           .|.
  Fly   559 QQQQHREHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADARDEHNDAK-----------QLQ 612

  Fly   327 LD-TD--------------------LDTSAN---------------------------------- 336
            || ||                    ||.:..
  Fly   613 LDQTDNIDGRVKCFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEEMKEA 677

  Fly   337 ------------------------TSGGLSHSSIDGYTSYKRVRRSEASLAQAAKCVSKGETFQT 377
                                    .||..|...:||  .|....:.:....:|.:|..:......
  Fly   678 AYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDG--GYNCEYKCKELNMRAIRCSRQQHMMSH 740

  Fly   378 VS---------------NMFNIPVSTIRFYMARKGILPKRKRGRGASHAGNIIITTNSGKLSTVP 427
            .|               ..::.||:..:.|:|..|.:.:........||.:        :|...|
  Fly   741 YSPHHPHHRSLIDCPAEAAYSPPVANNQAYLASNGAVQQLDLSTYHGHANH--------QLHQHP 797

  Fly   428 ASITHPPAHPHIHTNPLPHTQSQQ---MSMDSLHLK-AGIANTSGSNSPATATATSMSPSFDMAT 488
            .|.|||.     |:...||..|..   ....|:.:. ||.|:.|.:::||:...:::||....::
  Fly   798 PSATHPS-----HSQSSPHYPSASGAGAGAGSVSVSIAGSASGSATSAPASVATSAVSPQPSSSS 857

  Fly   489 TGDIVPFHLHSDAAA 503
            ||..      |.|||
  Fly   858 TGST------SSAAA 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8924	NP_573091.1	BTB	25..117	CDD:279045	44/91 (48%)
		BTB	34..117	CDD:197585	42/82 (51%)
		MerR	378..407	CDD:278788	6/43 (14%)
fru	NP_001163648.1	BTB	126..221	CDD:279045	46/95 (48%)
		BTB	137..221	CDD:197585	44/84 (52%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451913
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950