DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8924 and BtbVII

DIOPT Version :9

Sequence 1:	NP_573091.1	Gene:	CG8924 / 32557	FlyBaseID:	FBgn0030710	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	630	Identity:	159/630 - (25%)
Similarity:	255/630 - (40%)	Gaps:	182/630 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ATQEFCVRWNSHLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCK 68
            :.|:||:|||:|..:..:....||.....||||||.||:|:..|::||:|||:||:|:...:||:
  Fly     2 SVQQFCLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQ 66

  Fly    69 HPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAEQLQIRGLYGSEAPINYKKLQQAS 133
            ||::|| ::::..:::.:|||||.|||||:|..|..:|:.||.|:|:||  :|.|.:...|.::.
  Fly    67 HPIVIL-KDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGL--AEMPTDPANLTKSD 128

  Fly   134 LEAAKD--------PAATTARSFKHVDSAETDDAATNSTTSTTMTTSS----------------A 174
            .:::.|        ...|.|.     :||.:..|.:.|:...::.:||                |
  Fly   129 SKSSTDGTEMVGGAGVGTGAG-----NSAGSLGAGSGSSVGDSLWSSSEAQQFQQQQQQQAQQQA 188

  Fly   175 PPLPVNHQQPTVLKRQNPDARQQQQQQQ------QQQVQQRPQINGSNAQQ----PS-------- 221
            .....:|||...|::|...|:|||||||      |||...:.|...::..|    ||
  Fly   189 QQQHHHHQQQQQLQQQQQQAQQQQQQQQHHHHHHQQQQSGQAQAAQTHHHQMRRTPSPLSAGTSP 253

  Fly   222 -------KATSTNVLGSHSNAPTEDDSGDEVPNNWNAYGEQFDDCNISAQAVDNKMNVHLSLQQA 279
                   :.:|.|..|..:||..:.:|..:..:.....|......|.........:..| ||..|
  Fly   254 ATRRKRLRKSSNNGSGDRNNAEEQHNSSLDAGSGAGNAGLSLAQMNQMTFGAGGGLAGH-SLHAA 317

  Fly   280 RM-----QMQLQQQQYLDSNVEDDHNYV---------------------------AAHD-ENNDS 311
            ::     ..:|:||.. ||:::|.|.::                           :.|| .|:.|
  Fly   318 KLLKESASAELEQQPQ-DSDLDDGHGHLHMQIKPEVDIGGVNQTMPLDISGGTTPSEHDAPNSQS 381

  Fly   312 SFATGVPC------------------GSGL-----------SLSLDTDLDTSANTSGGLSHSSID 347
            |.:...|.                  |||.           |:..|.|...|:....|...:.:
  Fly   382 SHSEPSPAHAPHPPHPPLGAASSSSGGSGSFERSFSIGGVGSVECDPDGTPSSPAVMGTKRNRV- 445

  Fly   348 GYTSYKRVRRSEASLAQAAKCVSKGETFQTVS----NMFNIPVSTIRFYMARKGILPKRKRGRGA 408
             .|...||:|...|::...: :|......|:.    |......:|.|.|..           .|:
  Fly   446 -LTRQPRVKRDSDSISSTNQ-ISPDTAATTLDFDPFNAAGATSATARDYST-----------TGS 497

  Fly   409 SHAGNIIITTNSGKLSTVPASI----THP-----PAHPHI-------------HTNPLPHTQSQQ 451
            .|..:.....:...|.|||..|    :.|     |:.||:             |::||...||
  Fly   498 HHLHHQSAVHHHHHLLTVPPRIERHASEPAPSLAPSTPHLLSVPSSTPYLIKQHSDPLLPRQS-- 560

  Fly   452 MSMDSLHLKAGIANTSGSNSPATATATSMSPSFDMATTGDIVPFH 496
                :||: ||    |||.| ::|.||..:|         ..|.|
  Fly   561 ----ALHM-AG----SGSGS-SSAMATGSNP---------FAPLH 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8924	NP_573091.1	BTB	25..117	CDD:279045	43/91 (47%)
		BTB	34..117	CDD:197585	40/82 (49%)
		MerR	378..407	CDD:278788	4/32 (13%)
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	45/95 (47%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	42/87 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.110