DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stim and stim2

DIOPT Version :9

Sequence 1:	NP_523357.2	Gene:	Stim / 32556	FlyBaseID:	FBgn0045073	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_004916816.2	Gene:	stim2 / 733739	XenbaseID:	XB-GENE-992607	Length:	748	Species:	Xenopus tropicalis

Alignment Length:	450	Identity:	190/450 - (42%)
Similarity:	275/450 - (61%)	Gaps:	28/450 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 ACAADDFDCYSGSV---QDRFGMEAIASLHRQLDDDDNGNIDLSESDDFLREELKYDSGYEKRQK 186
            |..:|.|:..|..|   .||..:|||.::|:|:|||.:|.|::.|||:||||:|.|.   :..||
Frog    77 ALLSDPFNSLSPPVLTEDDRSSLEAICTIHKQMDDDKDGGIEVEESDEFLREDLNYK---DASQK 138

  Fly   187 AFHFN-DDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVDLFKLHKVTGAALPRLAV 250
            ..|.: :|.||:|::||..|..|||||||.|:|..||.:.|:||||...|:.:.|.|.||||:||
Frog   139 HNHLHREDKHITVEDLWAQWKTSEVHNWTEEETLQWLLEFVELPQYEKNFRENSVKGTALPRIAV 203

  Fly   251 NNLQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRETGTRW-KDYILVTLLLSAIIGCWYAYQQN 314
            |....:.:.|.|.|..|:||..|||:||||||||......| ||:||...::..:.|||:||.||
Frog   204 NEPVLMISQLKITDRSHRQKFQLKALDVVLFGPPTRPPHNWVKDFILTISIVIGVGGCWFAYTQN 268

  Fly   315 KNAKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDLERRL--------KEAPT 371
            :.:|.|:.:|.:|:||||:||.||.|:|..||:|:.|...||.||.:|||::        :||..
Frog   269 RTSKEHISQMMKDLEGLQKAEISLLELQDRLEKAQEENRTVAVEKQNLERKMMDEISDAKREAHR 333

  Fly   372 LSS--SNSDLEVQQLK---KEIEMLRNELSRA--EFELVDNCWSPPPQLQSWLQYTYELESKNHQ 429
            |..  ..::.|:.:||   :|:..:|..|.:|  ||||..| ||.|..||.|||.|:|:|.:.:.
Frog   334 LRELREGAECELSRLKYAEEELVQVRMALKKAEKEFELRSN-WSVPETLQKWLQLTHEVEVQYYN 397

  Fly   430 KKRTSAEKQLQSAREACEKLRKKRSSLVGAFVSTHGKSIDDVDRSIVEARNALGDVTNELQERLH 494
            .|:.:||..|..|::..||::||||::.|.....|..|:|:||..|:||:.||.::|..|:|||:
Frog   398 IKKQNAEMHLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLY 462

  Fly   495 RWKQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGMSSTKGSRARITNSTEDLDDES 554
            ||:|||...|..||:|:|||.|.:.||..:    |.:.|.........|....:|||:::
Frog   463 RWQQIEKMCGFPIVHNSGLPNLTSTLYSDH----SWVVMPRVSIPPYPIAGGVDDLDEDT 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stim	NP_523357.2	SAM_STIM-1,2-like	209..282	CDD:188903	38/72 (53%)
		SAM	210..271	CDD:197735	29/60 (48%)
		GBP_C	<312..392	CDD:303769	34/92 (37%)
		coiled coil	360..372	CDD:293879	5/19 (26%)
		coiled coil	381..392	CDD:293879	3/13 (23%)
		SOAR	410..507	CDD:293141	42/96 (44%)
stim2	XP_004916816.2	SAM_STIM2	162..235	CDD:188973	38/72 (53%)
		Smc	<268..>453	CDD:224117	74/185 (40%)
		SOAR	378..475	CDD:406837	42/96 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6270
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2366
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185000at33208
OrthoFinder	1	1.000	-	-		FOG0001884
OrthoInspector	1	1.000	-	-		otm49137
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060