DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stim and STIM2

DIOPT Version :9

Sequence 1:	NP_523357.2	Gene:	Stim / 32556	FlyBaseID:	FBgn0045073	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001162589.1	Gene:	STIM2 / 57620	HGNCID:	19205	Length:	754	Species:	Homo sapiens

Alignment Length:	475	Identity:	188/475 - (39%)
Similarity:	278/475 - (58%)	Gaps:	44/475 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SMGSGSADGACAADDF------DCYSGS-----VQDRFGMEAIASLHRQLDDDDNGNIDLSESDD 169
            |..:.::..|.||.|.      .|.|.|     .:|||.:||:.::|:|:|||.:|.|::.|||:
Human    30 SAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVEESDE 94

  Fly   170 FLREELKYDSGYEKRQKAFHFN-DDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVD 233
            |:||::||.....|..   |.: :|.||::::||:.|..|||||||:|.|..||.:.|:||||..
Human    95 FIREDMKYKDATNKHS---HLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQYEK 156

  Fly   234 LFKLHKVTGAALPRLAVNNLQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRETGTRW-KDYILV 297
            .|:.:.|.|..|||:||:...::.:.|.|.|..|:||:.|||:|||||||.......| ||:||.
Human   157 NFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILT 221

  Fly   298 TLLLSAIIGCWYAYQQNKNAKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDL 362
            ..::..:.|||:||.|||.:|.|:.:|.:|:|.||.|||||.::|:.||:|:.|..|||.||.:|
Human   222 VSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNL 286

  Fly   363 ERRL--------KEAPTLSSSNSDLEV-----QQLKKEIEMLRNELSRA--EFELVDNCWSPPPQ 412
            ||::        :||..|.......|.     |..::|:|.:|..|.:|  |||| .:.||.|..
Human   287 ERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFEL-RSSWSVPDA 350

  Fly   413 LQSWLQYTYELESKNHQKKRTSAEKQLQSARE--------ACEKLRKKRSSLVGAFVSTHGKSID 469
            ||.|||.|:|:|.:.:..||.:||.||..|::        ..||::||||::.|.....|..|:|
Human   351 LQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEVAASYLIQAEKIKKKRSTVFGTLHVAHSSSLD 415

  Fly   470 DVDRSIVEARNALGDVTNELQERLHRWKQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGMS 534
            :||..|:||:.||.::|..|:|||.||:|||...|..|.:|:|||.|.:.||..:    |.:.|.
Human   416 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDH----SWVVMP 476

  Fly   535 STKGSRARITNSTEDLDDES 554
            ........|....:|||:::
Human   477 RVSIPPYPIAGGVDDLDEDT 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stim	NP_523357.2	SAM_STIM-1,2-like	209..282	CDD:188903	36/72 (50%)
		SAM	210..271	CDD:197735	27/60 (45%)
		GBP_C	<312..392	CDD:303769	35/92 (38%)
		coiled coil	360..372	CDD:293879	5/19 (26%)
		coiled coil	381..392	CDD:293879	3/15 (20%)
		SOAR	410..507	CDD:293141	44/104 (42%)
STIM2	NP_001162589.1	SAM_STIM2	132..205	CDD:188973	36/72 (50%)
		SAM	133..197	CDD:197735	28/63 (44%)
		SOAR	348..453	CDD:293141	44/104 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..570		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..754
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160071
Domainoid	1	1.000	105	1.000	Domainoid score	I6650
eggNOG	1	0.900	-	-		E1_KOG4403
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2387
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185000at33208
OrthoFinder	1	1.000	-	-		FOG0001884
OrthoInspector	1	1.000	-	-		otm41914
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15136
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860