DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stim and kif5c

DIOPT Version :9

Sequence 1:	NP_523357.2	Gene:	Stim / 32556	FlyBaseID:	FBgn0045073	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001116747.1	Gene:	kif5c / 565563	ZFINID:	ZDB-GENE-081105-14	Length:	985	Species:	Danio rerio

Alignment Length:	486	Identity:	101/486 - (20%)
Similarity:	173/486 - (35%)	Gaps:	146/486 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 EAIASLHRQLDD-DDNGNIDLSESDDFLREELKYDS-------GYEKRQKAFH----FNDDMHIS 197
            |.|..|::|||| ||..|.....::|..::.:..|.       .|||.|:..:    .|:.....
Zfish   415 ELINDLYQQLDDKDDEINQHSQLAEDLKQQMVDQDELLASTRRDYEKIQEDLNRLQRENETAKEE 479

  Fly   198 VKELWEAWLRSEVHNW------------TIEQTTDWLAQSV--------QLPQYVDLFKLHKVTG 242
            |||:.:| |.....|:            |..|.:|.|.|..        .|....:|.:.|:...
Zfish   480 VKEVLQA-LEELAVNYDQKSHEVEEKSKTNNQLSDELVQKSSALAGVERDLSSLKELSEHHRRRS 543

  Fly   243 AALPRLAVNNLQYVGNVLGIKDP-------------------IHKQKISLKAM------------ 276
            |.:..|.:.:|..:|:|:.:.|.                   |.|.|..:|::
Zfish   544 AEILSLLLRDLCEIGSVIALNDHKLSELNGGMEEEFTMARLFISKMKSEVKSLVNRSKQLESTQS 608

  Fly   277 DVVLFGPPRETGTRWKDYILVTLLLS---AIIGCWYAYQQNKNAKRHLRRMAQDMEGLQRAEQSL 338
            |.:     |:.....|:.....:|:|   |.|.....|.||...|:            ::.|:|.
Zfish   609 DTM-----RKMQANEKELASCQMLISQHQAKIKSLTDYMQNMEQKK------------RQLEESH 656

  Fly   339 QEMQKELERARMEQENVATEKLDLER----RLKEAPTLSSS-----NSDLEVQQLKKEIEMLRNE 394
            ..:.:||.:...|:.......||.|:    |:::|..:..:     .|..|..|  |::..||:|
Zfish   657 DSLTEELAKLHAEERMHEVSVLDKEKEHMSRMQDAEEMKKALEQQMESHRETHQ--KQLSRLRDE 719

  Fly   395 LSRAEFELVDNCWSPPPQL---QSWLQYTYELESKNHQKKRTSAEKQL---QSAREACEKLRKKR 453
            :...: .::|........|   |..|...||...:..|||....:|.|   :...:|.|.|:...
Zfish   720 IEEKQ-RILDELKDVNQALELEQKKLMSDYEKLQQEDQKKDERLQKLLFLNEKKEQAKEDLKGLE 783

  Fly   454 SSLVGAFVSTH--------------GKSID-DVDRS---------IVEARNALGDVTNELQERLH 494
            .::.....:.|              |:|:: |.|.|         |:...|.|..:|     ::|
Zfish   784 ETVAKELQTLHDLRKLFIQDINNRIGRSVELDTDESGGSLAQKQKIIFLENNLEQLT-----KVH 843

  Fly   495 RWKQIETCLGLNIVNNNG-----LPYLENVL 520
            :          .:|::|.     ||.||..|
Zfish   844 K----------QLVHDNADLRCELPKLEKRL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stim	NP_523357.2	SAM_STIM-1,2-like	209..282	CDD:188903	20/123 (16%)
		SAM	210..271	CDD:197735	17/99 (17%)
		GBP_C	<312..392	CDD:303769	17/88 (19%)
		coiled coil	360..372	CDD:293879	5/15 (33%)
		coiled coil	381..392	CDD:293879	2/10 (20%)
		SOAR	410..507	CDD:293141	24/126 (19%)
kif5c	NP_001116747.1	KISc_KHC_KIF5	6..326	CDD:276820
		Kinesin	14..326	CDD:278646
		GBP_C	<638..766	CDD:303769	31/142 (22%)
		PKK	656..804	CDD:289257	30/150 (20%)
		coiled coil	733..744	CDD:293879	2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000