DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stim and stim1a

DIOPT Version :9

Sequence 1:	NP_523357.2	Gene:	Stim / 32556	FlyBaseID:	FBgn0045073	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_005173449.1	Gene:	stim1a / 556360	ZFINID:	ZDB-GENE-060503-914	Length:	808	Species:	Danio rerio

Alignment Length:	465	Identity:	188/465 - (40%)
Similarity:	275/465 - (59%)	Gaps:	52/465 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 CAADDFDCYSGSVQDR---FGMEAIASLHRQLDDDDNGNIDLSESDDFLREELKYDSGYEKRQKA 187
            |..|:..|     ||.   ...|||.|:|:|:|||||||:|:.|:|.||||:|.|... :.:...
Zfish    43 CRIDEPLC-----QDENAILSFEAIRSIHKQMDDDDNGNVDVLETDGFLREDLNYHDP-KGKHNT 101

  Fly   188 FHFNDDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVDLFKLHKVTGAALPRLAVNN 252
            || .||..|||::||.||..|||:|||:::...||...|:|.|||:..|....:|.|:|||||.|
Zfish   102 FH-GDDQFISVEDLWNAWKSSEVYNWTVDEVVKWLIDYVELTQYVEAIKKLNFSGTAMPRLAVKN 165

  Fly   253 LQYVGNVLGIKDPIHKQKISLKAMDVVLFGPP-RETGTRWKDYILVTLLLSAIIGCWYAYQQNKN 316
            ......||.|.|..|.||:.|||:|.||||.| .......||::||..::..:.|||:||.||::
Zfish   166 NTLTQTVLKILDRSHVQKLQLKALDTVLFGAPMMNRHNHLKDFMLVVSIVIGMGGCWFAYIQNRH 230

  Fly   317 AKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDLERRLKEAPTLSSSNSDLEV 381
            :|.|:::|.:|::.||||||||.::|::|:.|:.|..:|..||::||::|::    ..:.:..|.
Zfish   231 SKDHMKKMMKDLDSLQRAEQSLHDLQQKLQIAQEEHRSVEVEKVNLEQKLRD----EINTAKQEA 291

  Fly   382 QQLK-----------------KEIEMLRNELSRAEFELVD-NCWSPPPQLQSWLQYTYELESKNH 428
            |:||                 :|:|.:|..|.:||.||.. :.||||..||.|||.|:|:|.:.:
Zfish   292 QRLKELREGTENELSRQKYAEEELEQVRMALKKAEKELESRSSWSPPEALQKWLQLTHEVEVQYY 356

  Fly   429 QKKRTSAEKQLQSAREACEKLRKKRSSLVGAFVSTHGKSIDDVDRSIVEARNALGDVTNELQERL 493
            ..|:.:||:|||.|:|..||::|||::|.|.|...|..|:||||..|:.|:.|||:||..|:|||
Zfish   357 NIKKQNAERQLQVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILAAKQALGEVTAALRERL 421

  Fly   494 HRWKQIETCLGLNIVNNNGLPYLENVL------YGRNGGLQSSMGMSSTKGSRARITNSTEDLDD 552
            |||:|||...|..:|:|.|||.|.:.|      .|..|..|..|            ::..:|:|:
Zfish   422 HRWQQIELLTGFTLVHNPGLPSLASALNLDPSFMGGRGTPQHFM------------SDDMDDMDE 474

  Fly   553 ESI-QGKLNF 561
            :.: .|.|.:
Zfish   475 DIVPPGTLQY 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stim	NP_523357.2	SAM_STIM-1,2-like	209..282	CDD:188903	34/72 (47%)
		SAM	210..271	CDD:197735	26/60 (43%)
		GBP_C	<312..392	CDD:303769	30/96 (31%)
		coiled coil	360..372	CDD:293879	3/11 (27%)
		coiled coil	381..392	CDD:293879	5/27 (19%)
		SOAR	410..507	CDD:293141	49/96 (51%)
stim1a	XP_005173449.1	SAM_STIM1	122..195	CDD:188972	34/72 (47%)
		RILP-like	<227..330	CDD:304877	35/106 (33%)
		SOAR	338..435	CDD:293141	49/96 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596381
Domainoid	1	1.000	113	1.000	Domainoid score	I6085
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20681
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2395
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185000at33208
OrthoFinder	1	1.000	-	-		FOG0001884
OrthoInspector	1	1.000	-	-		otm24211
orthoMCL	1	0.900	-	-		OOG6_106940
Panther	1	1.100	-	-	O	PTHR15136
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860