DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stim and Stim1

DIOPT Version :9

Sequence 1:	NP_523357.2	Gene:	Stim / 32556	FlyBaseID:	FBgn0045073	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_006507596.1	Gene:	Stim1 / 20866	MGIID:	107476	Length:	793	Species:	Mus musculus

Alignment Length:	490	Identity:	195/490 - (39%)
Similarity:	292/490 - (59%)	Gaps:	46/490 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 QAVSNEFSSMGSGSADGA----------CAADDFDCYSGSVQDRFGMEAIASLHRQLDDDDNGNI 162
            |::|:..|...:|::.||          |..|...|:  |..::...||:.::|:.:|||.||::
Mouse    21 QSLSHSHSEKNTGASSGATSEESTEAEFCRIDKPLCH--SEDEKLSFEAVRNIHKLMDDDANGDV 83

  Fly   163 DLSESDDFLREELKYDSGYEKRQKAFHFNDDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQ 227
            |:.|||:||||:|.|.....| ...|| .:|..|||::||:||..|||:|||:::...||...|:
Mouse    84 DVEESDEFLREDLNYHDPTVK-HSTFH-GEDKLISVEDLWKAWKSSEVYNWTVDEVIQWLITYVE 146

  Fly   228 LPQYVDLFKLHKVTGAALPRLAVNNLQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRET-GTRW 291
            ||||.:.|:..::||.|:|||||.|....|.||.:.|..|:||:.|||:|.||||||..| ....
Mouse   147 LPQYEETFRKLQLTGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHL 211

  Fly   292 KDYILVTLLLSAIIGCWYAYQQNKNAKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVA 356
            ||::||..::..:.|||:||.||:.:|.|:::|.:|:|||.||||||.::|:.|.:|:.|...|.
Mouse   212 KDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVE 276

  Fly   357 TEKLDLERRLKEAPTLSSSNSDLEVQQLK-----------------KEIEMLRNELSRAEFELVD 404
            .||:.||::|::...|:..    |.|:||                 :|:|.:|..|.:||.||..
Mouse   277 VEKVHLEKKLRDEINLAKQ----EAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELES 337

  Fly   405 -NCWSPPPQLQSWLQYTYELESKNHQKKRTSAEKQLQSAREACEKLRKKRSSLVGAFVSTHGKSI 468
             :.|..|..||.|||.|:|:|.:.:..|:.:||:||..|:|..||::|||::|.|.|...|..|:
Mouse   338 HSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAERQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSL 402

  Fly   469 DDVDRSIVEARNALGDVTNELQERLHRWKQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGM 533
            ||||..|:.|:.||.:||..|:||||||:|||...|..||||.|:..|...|     .:..|. |
Mouse   403 DDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAAL-----NIDPSW-M 461

  Fly   534 SSTKGSRAR--ITNSTEDLDDESIQGKLNFENFSL 566
            .||:.:.|.  :|:..:|:|:| |...|:.::.||
Mouse   462 GSTRPNPAHFIMTDDVDDMDEE-IVSPLSMQSPSL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stim	NP_523357.2	SAM_STIM-1,2-like	209..282	CDD:188903	35/72 (49%)
		SAM	210..271	CDD:197735	27/60 (45%)
		GBP_C	<312..392	CDD:303769	32/96 (33%)
		coiled coil	360..372	CDD:293879	3/11 (27%)
		coiled coil	381..392	CDD:293879	5/27 (19%)
		SOAR	410..507	CDD:293141	47/96 (49%)
Stim1	XP_006507596.1	SAM_STIM1	128..201	CDD:188972	35/72 (49%)
		Smc	<237..>434	CDD:224117	81/200 (41%)
		SOAR	344..441	CDD:374610	47/96 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850441
Domainoid	1	1.000	104	1.000	Domainoid score	I6701
eggNOG	1	0.900	-	-		E1_KOG4403
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20681
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2362
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S4367
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185000at33208
OrthoFinder	1	1.000	-	-		FOG0001884
OrthoInspector	1	1.000	-	-		otm43962
orthoMCL	1	0.900	-	-		OOG6_106940
Panther	1	1.100	-	-	O	PTHR15136
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1416
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.710